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- W2108398384 abstract "Immunotoxins are conjugates in which monoclonal antibodies or their fragments are linked, normally via a disulfide bond, to either holotoxins or their toxic subunits. If the monoclonal antibody is cell-type-specific for a surface antigen, the immunotoxin should be cytotoxic to the antigen-bearing cells but not to other cell types. In general, while immunotoxins containing whole toxins exhibit greater cytotoxicity than immunotoxins lacking a toxin cell-binding polypeptide, their target cell specificity is inevitably reduced. The usefulness and limitations of current constructs are discussed, together with the prospects for developing immunotoxins with improved therapeutic potential using recombinant DNA techniques." @default.
- W2108398384 created "2016-06-24" @default.
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- W2108398384 date "1988-12-01" @default.
- W2108398384 modified "2023-09-24" @default.
- W2108398384 title "Immunotoxins: properties, applications and current limitations" @default.
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- W2108398384 doi "https://doi.org/10.1016/0169-409x(88)90012-9" @default.
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