FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108399897> ?p ?o ?g. }

• W2108399897 endingPage "e114441" @default.
• W2108399897 startingPage "e114441" @default.
• W2108399897 abstract "The circulating recombinant form (CRF) 07_BC is the most prevalent HIV-1 strain among injection drug users (IDUs) in Taiwan. It contains a 7 amino-acid deletion in its p6gag. We conducted a cohort study to compare viral loads and CD4 cell count changes between patients infected with subtype B and CRF07_BC and to elucidate its mechanism. Twenty-one patients infected with CRF07_BC and 59 patients with subtype B were selected from a cohort of 667 HIV-1/AIDS patients whom have been followed up for 3 years. Generalized estimated equation was used to analyze their clinical data and the results showed that patients infected with CRF07_BC had significantly lower viral loads (about 58,000 copies per ml less) than patients with subtype B infection (p = 0.002). The replicative capacity of nine CRF07_BC and four subtype B isolates were compared and the results showed that the former had significantly lower replicative capacity than the latter although all of them were CCR5- tropic and non-syncytium inducing viruses. An HIV-1-NL4-3 mutant virus which contains a 7 amino-acid deletion in p6gag (designated as 7d virus) was generated and its live cycle was investigated. The results showed that 7d virus had significantly lower replication capacity, poorer protease-mediated processing and viral proteins production. Electron microscopic examination of cells infected with wild-type or 7d virus demonstrated that the 7d virus had poorer and slower viral maturation processes: more viruses attached to the cell membrane and higher proportion of immature virions outside the cells. The interaction between p6gag and Alix protein was less efficient in cells infected with 7d virus. In conclusion, patients infected with CRF07_BC had significantly lower viral loads than patients infected with subtype B and it may due to the deletion of 7 amino acids which overlaps with Alix protein-binding domain of the p6gag." @default.
• W2108399897 created "2016-06-24" @default.
• W2108399897 creator A5006732904 @default.
• W2108399897 creator A5018983942 @default.
• W2108399897 creator A5022547338 @default.
• W2108399897 creator A5029782253 @default.
• W2108399897 creator A5033780365 @default.
• W2108399897 creator A5050475671 @default.
• W2108399897 creator A5055827613 @default.
• W2108399897 creator A5058715015 @default.
• W2108399897 creator A5058724362 @default.
• W2108399897 creator A5060352926 @default.
• W2108399897 creator A5062851453 @default.
• W2108399897 creator A5072183192 @default.
• W2108399897 creator A5072245275 @default.
• W2108399897 creator A5075764910 @default.
• W2108399897 creator A5081000027 @default.
• W2108399897 creator A5088992624 @default.
• W2108399897 date "2014-12-11" @default.
• W2108399897 modified "2023-10-05" @default.
• W2108399897 title "Patients Infected with CRF07_BC Have Significantly Lower Viral Loads than Patients with HIV-1 Subtype B: Mechanism and Impact on Disease Progression" @default.
• W2108399897 cites W1013429822 @default.
• W2108399897 cites W1778120063 @default.
• W2108399897 cites W1892408656 @default.
• W2108399897 cites W1900729316 @default.
• W2108399897 cites W1963813322 @default.
• W2108399897 cites W1965859532 @default.
• W2108399897 cites W1968137765 @default.
• W2108399897 cites W1971035497 @default.
• W2108399897 cites W1976566530 @default.
• W2108399897 cites W1978075866 @default.
• W2108399897 cites W1980798766 @default.
• W2108399897 cites W1999758531 @default.
• W2108399897 cites W2000695343 @default.
• W2108399897 cites W2000884295 @default.
• W2108399897 cites W2012139740 @default.
• W2108399897 cites W2018808081 @default.
• W2108399897 cites W2022050193 @default.
• W2108399897 cites W2022380758 @default.
• W2108399897 cites W2023420720 @default.
• W2108399897 cites W2027004120 @default.
• W2108399897 cites W2028972269 @default.
• W2108399897 cites W2037779396 @default.
• W2108399897 cites W2041363009 @default.
• W2108399897 cites W2044948966 @default.
• W2108399897 cites W2049046832 @default.
• W2108399897 cites W2057578063 @default.
• W2108399897 cites W2065741012 @default.
• W2108399897 cites W2066354913 @default.
• W2108399897 cites W2066529781 @default.
• W2108399897 cites W2068002734 @default.
• W2108399897 cites W2084625955 @default.
• W2108399897 cites W2088222944 @default.
• W2108399897 cites W2089471930 @default.
• W2108399897 cites W2104967459 @default.
• W2108399897 cites W2105307973 @default.
• W2108399897 cites W2105985803 @default.
• W2108399897 cites W2116956383 @default.
• W2108399897 cites W2117231776 @default.
• W2108399897 cites W2118233250 @default.
• W2108399897 cites W2141003640 @default.
• W2108399897 cites W2144685102 @default.
• W2108399897 cites W2145502651 @default.
• W2108399897 cites W2162727140 @default.
• W2108399897 cites W2166914988 @default.
• W2108399897 cites W2292638872 @default.
• W2108399897 cites W2327218410 @default.
• W2108399897 cites W4236032909 @default.
• W2108399897 cites W57829219 @default.
• W2108399897 doi "https://doi.org/10.1371/journal.pone.0114441" @default.
• W2108399897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4263662" @default.
• W2108399897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25502811" @default.
• W2108399897 hasPublicationYear "2014" @default.
• W2108399897 type Work @default.
• W2108399897 sameAs 2108399897 @default.
• W2108399897 citedByCount "21" @default.
• W2108399897 countsByYear W21083998972015 @default.
• W2108399897 countsByYear W21083998972016 @default.
• W2108399897 countsByYear W21083998972017 @default.
• W2108399897 countsByYear W21083998972018 @default.
• W2108399897 countsByYear W21083998972019 @default.
• W2108399897 countsByYear W21083998972020 @default.
• W2108399897 countsByYear W21083998972021 @default.
• W2108399897 countsByYear W21083998972022 @default.
• W2108399897 countsByYear W21083998972023 @default.
• W2108399897 crossrefType "journal-article" @default.
• W2108399897 hasAuthorship W2108399897A5006732904 @default.
• W2108399897 hasAuthorship W2108399897A5018983942 @default.
• W2108399897 hasAuthorship W2108399897A5022547338 @default.
• W2108399897 hasAuthorship W2108399897A5029782253 @default.
• W2108399897 hasAuthorship W2108399897A5033780365 @default.
• W2108399897 hasAuthorship W2108399897A5050475671 @default.
• W2108399897 hasAuthorship W2108399897A5055827613 @default.
• W2108399897 hasAuthorship W2108399897A5058715015 @default.
• W2108399897 hasAuthorship W2108399897A5058724362 @default.
• W2108399897 hasAuthorship W2108399897A5060352926 @default.
• W2108399897 hasAuthorship W2108399897A5062851453 @default.
• W2108399897 hasAuthorship W2108399897A5072183192 @default.

• next