FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108400046> ?p ?o ?g. }

• W2108400046 endingPage "745" @default.
• W2108400046 startingPage "740" @default.
• W2108400046 abstract "Deoxycorticosterone-salt (DOCA-salt) hypertension is characterized by elevated vasoconstriction to agonists that stimulate G protein-mediated activation of phospholipase C. However, the mechanisms responsible for the augmented responsiveness are unknown. This study tested the hypothesis that this augmented vascular responsiveness is due to elevated content of G(alpha)q, the G protein alpha-subunit that activates phospholipase C. Thoracic aortae from DOCA-salt hypertensive rats (systolic blood pressure 183 +/- 7 mm Hg) and normotensive controls (systolic blood pressure 115 +/- 2 mm Hg) were homogenized and G protein content determined. Western analysis revealed that G(alpha)i content was decreased in DOCA compared with control rats (1364 +/- 196 versus 2343 +/- 188 densitometry units, P < or = .05) with no differences observed for G(alpha)q or G(alpha)s. In addition, contractile responses in denuded femoral artery strips revealed a significant decrease in EC50 values in DOCA arteries to all of the agonists examined: aluminum fluoride (DOCA = 1.42, control = 2.34 mmol/L), mastoparan (DOCA = 0.51, control = 35 micromol/L), phenylephrine (DOCA = 0.08, control = 0.53 micromol/L), and serotonin (DOCA = 0.014, control = 0.04 micromol/L, EC20 values). Finally, arteries from DOCA rats contracted with aluminum fluoride had increased sensitivity to G protein antagonists but not to a phospholipase C inhibitor. The enhanced contractile responsiveness in the DOCA arteries may be mediated in part through decreased G(alpha)i levels. However, it is not caused by increased concentrations of G(alpha)q in the cell membrane or by increased phospholipase C sensitivity, and the increased constrictor response to G protein stimulators of phospholipase C appears to depend primarily on increased G protein sensitivity." @default.
• W2108400046 created "2016-06-24" @default.
• W2108400046 creator A5019812107 @default.
• W2108400046 creator A5020925944 @default.
• W2108400046 date "1996-03-01" @default.
• W2108400046 modified "2023-09-26" @default.
• W2108400046 title "Increased Responsiveness and Decreased Expression of G Proteins in Deoxycorticosterone Hypertension" @default.
• W2108400046 cites W115867921 @default.
• W2108400046 cites W1493349125 @default.
• W2108400046 cites W1498058603 @default.
• W2108400046 cites W1517658624 @default.
• W2108400046 cites W152264642 @default.
• W2108400046 cites W1565496454 @default.
• W2108400046 cites W1620006026 @default.
• W2108400046 cites W1753089048 @default.
• W2108400046 cites W189805976 @default.
• W2108400046 cites W1970216063 @default.
• W2108400046 cites W1983458197 @default.
• W2108400046 cites W2002930464 @default.
• W2108400046 cites W2004997587 @default.
• W2108400046 cites W2035781216 @default.
• W2108400046 cites W2050969912 @default.
• W2108400046 cites W2061707196 @default.
• W2108400046 cites W2066854425 @default.
• W2108400046 cites W2080384870 @default.
• W2108400046 cites W2080598768 @default.
• W2108400046 cites W2090231105 @default.
• W2108400046 cites W2100621754 @default.
• W2108400046 cites W2107465400 @default.
• W2108400046 cites W2166717031 @default.
• W2108400046 cites W2172495278 @default.
• W2108400046 cites W2419361691 @default.
• W2108400046 cites W4236913267 @default.
• W2108400046 doi "https://doi.org/10.1161/01.hyp.27.3.740" @default.
• W2108400046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8613234" @default.
• W2108400046 hasPublicationYear "1996" @default.
• W2108400046 type Work @default.
• W2108400046 sameAs 2108400046 @default.
• W2108400046 citedByCount "19" @default.
• W2108400046 countsByYear W21084000462012 @default.
• W2108400046 countsByYear W21084000462013 @default.
• W2108400046 countsByYear W21084000462015 @default.
• W2108400046 crossrefType "journal-article" @default.
• W2108400046 hasAuthorship W2108400046A5019812107 @default.
• W2108400046 hasAuthorship W2108400046A5020925944 @default.
• W2108400046 hasConcept C120770815 @default.
• W2108400046 hasConcept C126322002 @default.
• W2108400046 hasConcept C134018914 @default.
• W2108400046 hasConcept C159110408 @default.
• W2108400046 hasConcept C170493617 @default.
• W2108400046 hasConcept C185592680 @default.
• W2108400046 hasConcept C24998067 @default.
• W2108400046 hasConcept C2775944032 @default.
• W2108400046 hasConcept C2777952589 @default.
• W2108400046 hasConcept C2778597717 @default.
• W2108400046 hasConcept C2779961880 @default.
• W2108400046 hasConcept C2780253649 @default.
• W2108400046 hasConcept C49453240 @default.
• W2108400046 hasConcept C64943373 @default.
• W2108400046 hasConcept C71924100 @default.
• W2108400046 hasConcept C80631254 @default.
• W2108400046 hasConcept C84393581 @default.
• W2108400046 hasConceptScore W2108400046C120770815 @default.
• W2108400046 hasConceptScore W2108400046C126322002 @default.
• W2108400046 hasConceptScore W2108400046C134018914 @default.
• W2108400046 hasConceptScore W2108400046C159110408 @default.
• W2108400046 hasConceptScore W2108400046C170493617 @default.
• W2108400046 hasConceptScore W2108400046C185592680 @default.
• W2108400046 hasConceptScore W2108400046C24998067 @default.
• W2108400046 hasConceptScore W2108400046C2775944032 @default.
• W2108400046 hasConceptScore W2108400046C2777952589 @default.
• W2108400046 hasConceptScore W2108400046C2778597717 @default.
• W2108400046 hasConceptScore W2108400046C2779961880 @default.
• W2108400046 hasConceptScore W2108400046C2780253649 @default.
• W2108400046 hasConceptScore W2108400046C49453240 @default.
• W2108400046 hasConceptScore W2108400046C64943373 @default.
• W2108400046 hasConceptScore W2108400046C71924100 @default.
• W2108400046 hasConceptScore W2108400046C80631254 @default.
• W2108400046 hasConceptScore W2108400046C84393581 @default.
• W2108400046 hasIssue "3" @default.
• W2108400046 hasLocation W21084000461 @default.
• W2108400046 hasLocation W21084000462 @default.
• W2108400046 hasOpenAccess W2108400046 @default.
• W2108400046 hasPrimaryLocation W21084000461 @default.
• W2108400046 hasRelatedWork W1973129956 @default.
• W2108400046 hasRelatedWork W1975203043 @default.
• W2108400046 hasRelatedWork W2023307846 @default.
• W2108400046 hasRelatedWork W2030279594 @default.
• W2108400046 hasRelatedWork W2036202434 @default.
• W2108400046 hasRelatedWork W2090539466 @default.
• W2108400046 hasRelatedWork W2108400046 @default.
• W2108400046 hasRelatedWork W2132365889 @default.
• W2108400046 hasRelatedWork W2142204138 @default.
• W2108400046 hasRelatedWork W2314941988 @default.
• W2108400046 hasVolume "27" @default.
• W2108400046 isParatext "false" @default.
• W2108400046 isRetracted "false" @default.
• W2108400046 magId "2108400046" @default.

• next