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- W2108403907 abstract "Diaphragm activation can be quantified by measuring the root mean square of crural EMG (RMSdi) (Beck J, Sinderby C, Lindstrom L, and Grassino A, J Appl Physiol 85: 1123–1134, 1998). To examine intersubject and day-to-day variation in the RMSdi-Pco 2 relationship, end-tidal Pco 2 , minute ventilation (V̇e), respiratory frequency (f B ), and RMSdi were measured in seven healthy subjects on two occasions during steady-state ventilation at seven levels of inspired O 2 fraction (Fi CO 2 ) from 0 to 0.08 in random order. RMSdi was measured with a multielectrode esophageal catheter and controlled for signal contamination and diaphragm position. RMSdi was normalized for values obtained during quiet breathing at functional residual capacity, at Fi CO 2 of 0.04, and during an inspiratory capacity maneuver (RMSdi%max) as well as ECG R-wave amplitude at functional residual capacity (RMSdi/ECG R ), f B , and thickness of the costal diaphragm measured by ultrasound. RMSdi increased linearly with Pco 2 (mean r 2 = 0.83 ± 0.10); at the highest Fi CO 2 , RMSdi%max was 40.2 ± 11.6%. Relative to the intersubject variation in the V̇e-Pco 2 relationship, intersubject variations in the slopes and intercepts of the RMSdi-Pco 2 relationships were 1.7 and 1.8 times, respectively, and RMSdi%max-Pco 2 relationships 0.9 and 1.3 times, respectively, and were unrelated to f B and diaphragm thickness. Relative to the day-to-day variation in the V̇e-Pco 2 relationship, day-to-day variation in the slopes and intercepts of the RMSdi-Pco 2 relationships were 2.8 and 4.4 times, respectively, and RMSdi/ECG R -Pco 2 relationships 1.3 and 2.2 times, respectively. It was concluded that the RMSdi-Pco 2 relationship measures chemosensitivity and is best compared between subjects via RMSdi%max and on separate occasions in the same subject via RMSdi/ECG R ." @default.
- W2108403907 created "2016-06-24" @default.
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- W2108403907 date "2005-01-01" @default.
- W2108403907 modified "2023-10-18" @default.
- W2108403907 title "Diaphragm electromyogram root mean square response to hypercapnia and its intersubject and day-to-day variation" @default.
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- W2108403907 doi "https://doi.org/10.1152/japplphysiol.01380.2003" @default.
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