Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108405964> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2108405964 endingPage "1515" @default.
- W2108405964 startingPage "1505" @default.
- W2108405964 abstract "Pretreatment of mice with anti-asialo GM1, which has been shown to deplete NK cytolytic activity without affecting cytotoxic T cells or macrophages, increased the weak anti-PPS 6 responses of adult mice to levels similar to that of their anti-PPS 3 responses, and increased the weak-to-absent anti-PPS 3 and anti-PPS 6 responses of weanling mice to the same levels as achieved by adult mice. By contrast, pretreatment with poly(IC), which augments NK activity, resulted in a 14-fold reduction in the anti-PPS 3 responses of adult mice. The enhancement of anti-PPS responses in mice treated with anti-asialo GM1 was due to inactivation or depletion of NK cells, and not T suppressor cells, since this enhancement occurred in athymic nude mice as well as in euthymic mice. In addition, strains of mice with low or absent endogenous NK activity were found to have considerably stronger anti-PPS responses than strains of mice with normal NK activity. NK depletion enhanced anti-PPS 6 IgM but not IgG response, and resulted in a true increase in antibody production rather than an alteration in the time course of the response. These findings indicate that NK cells physiologically downregulate anti-PPS responses, and that age-dependent and type-specific variations in these responses are primarily determined by NK regulatory effects." @default.
- W2108405964 created "2016-06-24" @default.
- W2108405964 creator A5018709672 @default.
- W2108405964 creator A5059769565 @default.
- W2108405964 creator A5066297914 @default.
- W2108405964 creator A5076996005 @default.
- W2108405964 date "1986-11-01" @default.
- W2108405964 modified "2023-10-09" @default.
- W2108405964 title "Natural killer cell regulation of age-related and type-specific variations in antibody responses to pneumococcal polysaccharides." @default.
- W2108405964 cites W1526688251 @default.
- W2108405964 cites W1550310038 @default.
- W2108405964 cites W1564599513 @default.
- W2108405964 cites W1589443644 @default.
- W2108405964 cites W1590856297 @default.
- W2108405964 cites W1779504031 @default.
- W2108405964 cites W1808208212 @default.
- W2108405964 cites W1852160611 @default.
- W2108405964 cites W1913814259 @default.
- W2108405964 cites W1976394690 @default.
- W2108405964 cites W1981871581 @default.
- W2108405964 cites W1996870836 @default.
- W2108405964 cites W1997589851 @default.
- W2108405964 cites W2007082011 @default.
- W2108405964 cites W2007888049 @default.
- W2108405964 cites W2042081963 @default.
- W2108405964 cites W2061229343 @default.
- W2108405964 cites W2068995512 @default.
- W2108405964 cites W2085993549 @default.
- W2108405964 cites W2088381124 @default.
- W2108405964 cites W2092759342 @default.
- W2108405964 cites W2129278872 @default.
- W2108405964 cites W2143597677 @default.
- W2108405964 cites W2146784573 @default.
- W2108405964 cites W2238786570 @default.
- W2108405964 cites W2314665463 @default.
- W2108405964 doi "https://doi.org/10.1084/jem.164.5.1505" @default.
- W2108405964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188447" @default.
- W2108405964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2430043" @default.
- W2108405964 hasPublicationYear "1986" @default.
- W2108405964 type Work @default.
- W2108405964 sameAs 2108405964 @default.
- W2108405964 citedByCount "26" @default.
- W2108405964 countsByYear W21084059642017 @default.
- W2108405964 countsByYear W21084059642020 @default.
- W2108405964 countsByYear W21084059642021 @default.
- W2108405964 crossrefType "journal-article" @default.
- W2108405964 hasAuthorship W2108405964A5018709672 @default.
- W2108405964 hasAuthorship W2108405964A5059769565 @default.
- W2108405964 hasAuthorship W2108405964A5066297914 @default.
- W2108405964 hasAuthorship W2108405964A5076996005 @default.
- W2108405964 hasBestOaLocation W21084059641 @default.
- W2108405964 hasConcept C134018914 @default.
- W2108405964 hasConcept C154317977 @default.
- W2108405964 hasConcept C159654299 @default.
- W2108405964 hasConcept C202751555 @default.
- W2108405964 hasConcept C203014093 @default.
- W2108405964 hasConcept C2778102761 @default.
- W2108405964 hasConcept C2778433245 @default.
- W2108405964 hasConcept C55493867 @default.
- W2108405964 hasConcept C73588182 @default.
- W2108405964 hasConcept C86803240 @default.
- W2108405964 hasConcept C8891405 @default.
- W2108405964 hasConceptScore W2108405964C134018914 @default.
- W2108405964 hasConceptScore W2108405964C154317977 @default.
- W2108405964 hasConceptScore W2108405964C159654299 @default.
- W2108405964 hasConceptScore W2108405964C202751555 @default.
- W2108405964 hasConceptScore W2108405964C203014093 @default.
- W2108405964 hasConceptScore W2108405964C2778102761 @default.
- W2108405964 hasConceptScore W2108405964C2778433245 @default.
- W2108405964 hasConceptScore W2108405964C55493867 @default.
- W2108405964 hasConceptScore W2108405964C73588182 @default.
- W2108405964 hasConceptScore W2108405964C86803240 @default.
- W2108405964 hasConceptScore W2108405964C8891405 @default.
- W2108405964 hasIssue "5" @default.
- W2108405964 hasLocation W21084059641 @default.
- W2108405964 hasLocation W21084059642 @default.
- W2108405964 hasLocation W21084059643 @default.
- W2108405964 hasLocation W21084059644 @default.
- W2108405964 hasOpenAccess W2108405964 @default.
- W2108405964 hasPrimaryLocation W21084059641 @default.
- W2108405964 hasRelatedWork W147952344 @default.
- W2108405964 hasRelatedWork W1550137483 @default.
- W2108405964 hasRelatedWork W1977706282 @default.
- W2108405964 hasRelatedWork W2013228225 @default.
- W2108405964 hasRelatedWork W2029644809 @default.
- W2108405964 hasRelatedWork W2047712879 @default.
- W2108405964 hasRelatedWork W2156963489 @default.
- W2108405964 hasRelatedWork W2353012055 @default.
- W2108405964 hasRelatedWork W2360291613 @default.
- W2108405964 hasRelatedWork W2394521754 @default.
- W2108405964 hasVolume "164" @default.
- W2108405964 isParatext "false" @default.
- W2108405964 isRetracted "false" @default.
- W2108405964 magId "2108405964" @default.
- W2108405964 workType "article" @default.