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• W2108408972 abstract "Abstract Objective Whether or not a high risk of falls increases the risk of bleeding in patients receiving anticoagulants remains a matter of debate. Methods We conducted a prospective cohort study involving 991 patients ≥65 years of age who received anticoagulants for acute venous thromboembolism ( VTE ) at nine Swiss hospitals between S eptember 2009 and S eptember 2012. The study outcomes were as follows: the time to a first major episode of bleeding; and clinically relevant nonmajor bleeding. We determined the associations between the risk of falls and the time to a first episode of bleeding using competing risk regression, accounting for death as a competing event. We adjusted for known bleeding risk factors and anticoagulation as a time‐varying covariate. Results Four hundred fifty‐eight of 991 patients (46%) were at high risk of falls. The mean duration of follow‐up was 16.7 months. Patients at high risk of falls had a higher incidence of major bleeding (9.6 vs. 6.6 events/100 patient‐years; P = 0.05) and a significantly higher incidence of clinically relevant nonmajor bleeding (16.7 vs. 8.3 events/100 patient‐years; P < 0.001) than patients at low risk of falls. After adjustment, a high risk of falls was associated with clinically relevant nonmajor bleeding [subhazard ratio ( SHR ) = 1.74, 95% confidence interval ( CI ) = 1.23–2.46], but not with major bleeding ( SHR = 1.24, 95% CI = 0.83–1.86). Conclusion In elderly patients who receive anticoagulants because of VTE , a high risk of falls is significantly associated with clinically relevant nonmajor bleeding, but not with major bleeding. Whether or not a high risk of falls is a reason against providing anticoagulation beyond 3 months should be based on patient preferences and the risk of VTE recurrence." @default.
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• W2108408972 date "2014-04-16" @default.
• W2108408972 modified "2023-09-27" @default.
• W2108408972 title "Risk of falls and bleeding in elderly patients with acute venous thromboembolism" @default.
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• W2108408972 doi "https://doi.org/10.1111/joim.12236" @default.
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