FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108417414> ?p ?o ?g. }

• W2108417414 endingPage "856" @default.
• W2108417414 startingPage "846" @default.
• W2108417414 abstract "The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacological activation on markers of plaque vulnerability in vivo and in vitro. The study was conducted using all available residual human carotid tissues (upstream and downstream the blood flow) from our cohort of patients symptomatic (n = 13) or asymptomatic (n = 27) for ischaemic stroke. Intraplaque levels of 2-arachidonoylglycerol, anandamide N-arachidonoylethanolamine, N-palmitoylethanolamine, N-oleoylethanolamine, and their degrading enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) were not different in human plaque portions. In the majority of human samples, CB1 (both mRNA and protein levels) was undetectable. In downstream symptomatic plaques, CB2 protein expression was reduced when compared with asymptomatic patients. In these portions, CB2 levels were inversely correlated (r = −0.4008, P = 0.0170) with matrix metalloprotease (MMP)-9 content and positively (r = 0.3997, P = 0.0174) with collagen. In mouse plaques, CB2 co-localized with neutrophils and MMP-9. Treatment with the selective CB2 agonist JWH-133 was associated with the reduction in MMP-9 content in aortic root and carotid plaques. In vitro, pre-incubation with JWH-133 reduced tumour necrosis factor (TNF)-α-mediated release of MMP-9. This effect was associated with the reduction in TNF-α-induced ERK1/2 phosphorylation in human neutrophils. Cannabinoid receptor type 2 receptor is down-regulated in unstable human carotid plaques. Since CB2 activation prevents neutrophil release of MMP-9 in vivo and in vitro, this treatment strategy might selectively reduce carotid vulnerability in humans." @default.
• W2108417414 created "2016-06-24" @default.
• W2108417414 creator A5000488097 @default.
• W2108417414 creator A5007484138 @default.
• W2108417414 creator A5008114310 @default.
• W2108417414 creator A5012469924 @default.
• W2108417414 creator A5015165662 @default.
• W2108417414 creator A5016840262 @default.
• W2108417414 creator A5022177325 @default.
• W2108417414 creator A5023250159 @default.
• W2108417414 creator A5024812334 @default.
• W2108417414 creator A5025303945 @default.
• W2108417414 creator A5025470988 @default.
• W2108417414 creator A5032814504 @default.
• W2108417414 creator A5037781399 @default.
• W2108417414 creator A5041594491 @default.
• W2108417414 creator A5042094771 @default.
• W2108417414 creator A5046928883 @default.
• W2108417414 creator A5051011206 @default.
• W2108417414 creator A5052470519 @default.
• W2108417414 creator A5054156788 @default.
• W2108417414 creator A5056784492 @default.
• W2108417414 creator A5057741246 @default.
• W2108417414 creator A5059143691 @default.
• W2108417414 creator A5063515979 @default.
• W2108417414 creator A5066493363 @default.
• W2108417414 creator A5072146670 @default.
• W2108417414 creator A5073922153 @default.
• W2108417414 creator A5076799817 @default.
• W2108417414 creator A5085573148 @default.
• W2108417414 date "2011-11-22" @default.
• W2108417414 modified "2023-10-16" @default.
• W2108417414 title "The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques" @default.
• W2108417414 cites W1966711006 @default.
• W2108417414 cites W1972914668 @default.
• W2108417414 cites W1978307963 @default.
• W2108417414 cites W1984267035 @default.
• W2108417414 cites W1990752520 @default.
• W2108417414 cites W1990877246 @default.
• W2108417414 cites W2022986843 @default.
• W2108417414 cites W2031828723 @default.
• W2108417414 cites W2052101688 @default.
• W2108417414 cites W2056993290 @default.
• W2108417414 cites W2075099594 @default.
• W2108417414 cites W2095944755 @default.
• W2108417414 cites W2101816788 @default.
• W2108417414 cites W2136160086 @default.
• W2108417414 cites W2139026489 @default.
• W2108417414 cites W2141035535 @default.
• W2108417414 cites W2144797452 @default.
• W2108417414 cites W2316997036 @default.
• W2108417414 cites W2612334191 @default.
• W2108417414 cites W2767911074 @default.
• W2108417414 doi "https://doi.org/10.1093/eurheartj/ehr449" @default.
• W2108417414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3345556" @default.
• W2108417414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22112961" @default.
• W2108417414 hasPublicationYear "2011" @default.
• W2108417414 type Work @default.
• W2108417414 sameAs 2108417414 @default.
• W2108417414 citedByCount "75" @default.
• W2108417414 countsByYear W21084174142012 @default.
• W2108417414 countsByYear W21084174142013 @default.
• W2108417414 countsByYear W21084174142014 @default.
• W2108417414 countsByYear W21084174142015 @default.
• W2108417414 countsByYear W21084174142016 @default.
• W2108417414 countsByYear W21084174142017 @default.
• W2108417414 countsByYear W21084174142018 @default.
• W2108417414 countsByYear W21084174142019 @default.
• W2108417414 countsByYear W21084174142020 @default.
• W2108417414 countsByYear W21084174142021 @default.
• W2108417414 countsByYear W21084174142022 @default.
• W2108417414 crossrefType "journal-article" @default.
• W2108417414 hasAuthorship W2108417414A5000488097 @default.
• W2108417414 hasAuthorship W2108417414A5007484138 @default.
• W2108417414 hasAuthorship W2108417414A5008114310 @default.
• W2108417414 hasAuthorship W2108417414A5012469924 @default.
• W2108417414 hasAuthorship W2108417414A5015165662 @default.
• W2108417414 hasAuthorship W2108417414A5016840262 @default.
• W2108417414 hasAuthorship W2108417414A5022177325 @default.
• W2108417414 hasAuthorship W2108417414A5023250159 @default.
• W2108417414 hasAuthorship W2108417414A5024812334 @default.
• W2108417414 hasAuthorship W2108417414A5025303945 @default.
• W2108417414 hasAuthorship W2108417414A5025470988 @default.
• W2108417414 hasAuthorship W2108417414A5032814504 @default.
• W2108417414 hasAuthorship W2108417414A5037781399 @default.
• W2108417414 hasAuthorship W2108417414A5041594491 @default.
• W2108417414 hasAuthorship W2108417414A5042094771 @default.
• W2108417414 hasAuthorship W2108417414A5046928883 @default.
• W2108417414 hasAuthorship W2108417414A5051011206 @default.
• W2108417414 hasAuthorship W2108417414A5052470519 @default.
• W2108417414 hasAuthorship W2108417414A5054156788 @default.
• W2108417414 hasAuthorship W2108417414A5056784492 @default.
• W2108417414 hasAuthorship W2108417414A5057741246 @default.
• W2108417414 hasAuthorship W2108417414A5059143691 @default.
• W2108417414 hasAuthorship W2108417414A5063515979 @default.
• W2108417414 hasAuthorship W2108417414A5066493363 @default.
• W2108417414 hasAuthorship W2108417414A5072146670 @default.
• W2108417414 hasAuthorship W2108417414A5073922153 @default.

• next