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• W2108422551 startingPage "127" @default.
• W2108422551 abstract "Monoclonal antibodies (mAbs) are currently used for many diagnostic and therapeutic applications. The high demand for these biopharmaceuticals has led to the development of large-scale manufacturing processes, with productivity improvements being mainly achieved by optimization of bioreactor systems. However, more recently, the early steps of production, previous to bioreactor culture, have been presented as alternative areas where productivity enhancements can be achieved. Thus, this review describes the progress made for the improvement of productivity in mammalian expression systems for the high production of mAbs. Advances in the development of mAb-producing cell lines are being made, particularly regarding expression vector design and methods used for transfection, with the intent to create a reproducible methodology. Selection of the most suitable clones is also a critical step that can be improved, by including variables other than the expression level, which is still the common practice. Furthermore, strategies of cell engineering, although still mostly based on trial-and-error experimentation and not in standard protocols, hold great interest to improve cell growth and productivity, as well as product quality in the future. Improvements of the initial steps of the production process would not only result in cells with higher expression ability, but would also speed-up the process development." @default.
• W2108422551 created "2016-06-24" @default.
• W2108422551 creator A5008068226 @default.
• W2108422551 creator A5029481092 @default.
• W2108422551 creator A5051537044 @default.
• W2108422551 creator A5060670302 @default.
• W2108422551 creator A5063698025 @default.
• W2108422551 date "2010-02-01" @default.
• W2108422551 modified "2023-09-29" @default.
• W2108422551 title "Guidelines to cell engineering for monoclonal antibody production" @default.
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