FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108431211> ?p ?o ?g. }

• W2108431211 endingPage "3499" @default.
• W2108431211 startingPage "3499" @default.
• W2108431211 abstract "To examine the relevance of hypoxia inducible factor (HIF-1) and nitric oxide (NO) on the preservation of fatty liver against cold ischemia-reperfusion injury (IRI).We used an isolated perfused rat liver model and we evaluated HIF-1alpha in steatotic and non-steatotic livers preserved for 24 h at 4 degrees C in University of Wisconsin and IGL-1 solutions, and then subjected to 2 h of normothermic reperfusion. After normoxic reperfusion, liver enzymes, bile production, bromosulfophthalein clearance, as well as HIF-1alpha and NO [endothelial NO synthase (eNOS) activity and nitrites/nitrates] were also measured. Other factors associated with the higher susceptibility of steatotic livers to IRI, such as mitochondrial damage and vascular resistance were evaluated.A significant increase in HIF-1alpha was found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage. Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters. These benefits were enhanced by the addition of trimetazidine (an anti-ischemic drug), which induces NO and eNOS activation, to IGL-1 solution. In normoxic reperfusion, the presence of NO favors HIF-1alpha accumulation, promoting also the activation of other cytoprotective genes, such as heme-oxygenase-1.We found evidence for the role of the HIF-1alpha/NO system in fatty liver preservation, especially when IGL-1 solution is used." @default.
• W2108431211 created "2016-06-24" @default.
• W2108431211 creator A5001711479 @default.
• W2108431211 creator A5003010633 @default.
• W2108431211 creator A5015680333 @default.
• W2108431211 creator A5029587764 @default.
• W2108431211 creator A5031500541 @default.
• W2108431211 creator A5042051260 @default.
• W2108431211 creator A5062464445 @default.
• W2108431211 creator A5079349599 @default.
• W2108431211 creator A5083914547 @default.
• W2108431211 date "2010-01-01" @default.
• W2108431211 modified "2023-09-23" @default.
• W2108431211 title "Hypoxia inducible factor-1α accumulation in steatotic liver preservation: Role of nitric oxide" @default.
• W2108431211 cites W120883508 @default.
• W2108431211 cites W1861192650 @default.
• W2108431211 cites W1966065735 @default.
• W2108431211 cites W1970446214 @default.
• W2108431211 cites W1972488009 @default.
• W2108431211 cites W1977387249 @default.
• W2108431211 cites W1977975225 @default.
• W2108431211 cites W1978270167 @default.
• W2108431211 cites W1978834255 @default.
• W2108431211 cites W1980458823 @default.
• W2108431211 cites W1991843895 @default.
• W2108431211 cites W1996296697 @default.
• W2108431211 cites W2000018521 @default.
• W2108431211 cites W2008139703 @default.
• W2108431211 cites W2009812264 @default.
• W2108431211 cites W2012156297 @default.
• W2108431211 cites W2012864757 @default.
• W2108431211 cites W2015205016 @default.
• W2108431211 cites W2016710706 @default.
• W2108431211 cites W2020189193 @default.
• W2108431211 cites W2036358033 @default.
• W2108431211 cites W2044664384 @default.
• W2108431211 cites W2050971607 @default.
• W2108431211 cites W2064039718 @default.
• W2108431211 cites W2064517350 @default.
• W2108431211 cites W2065788180 @default.
• W2108431211 cites W2066394888 @default.
• W2108431211 cites W2070515925 @default.
• W2108431211 cites W2072353087 @default.
• W2108431211 cites W2072634616 @default.
• W2108431211 cites W2074204254 @default.
• W2108431211 cites W2082185635 @default.
• W2108431211 cites W2083618601 @default.
• W2108431211 cites W2083770932 @default.
• W2108431211 cites W2085609942 @default.
• W2108431211 cites W2087011043 @default.
• W2108431211 cites W2103382508 @default.
• W2108431211 cites W2105043010 @default.
• W2108431211 cites W2113620806 @default.
• W2108431211 cites W2119224030 @default.
• W2108431211 cites W2125703812 @default.
• W2108431211 cites W2142389819 @default.
• W2108431211 cites W2147703815 @default.
• W2108431211 cites W2147952042 @default.
• W2108431211 cites W2153267965 @default.
• W2108431211 cites W2161679746 @default.
• W2108431211 cites W2162468164 @default.
• W2108431211 cites W2168049751 @default.
• W2108431211 cites W2187105566 @default.
• W2108431211 cites W25138627 @default.
• W2108431211 cites W3142246808 @default.
• W2108431211 doi "https://doi.org/10.3748/wjg.v16.i28.3499" @default.
• W2108431211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909549" @default.
• W2108431211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20653058" @default.
• W2108431211 hasPublicationYear "2010" @default.
• W2108431211 type Work @default.
• W2108431211 sameAs 2108431211 @default.
• W2108431211 citedByCount "49" @default.
• W2108431211 countsByYear W21084312112012 @default.
• W2108431211 countsByYear W21084312112013 @default.
• W2108431211 countsByYear W21084312112014 @default.
• W2108431211 countsByYear W21084312112015 @default.
• W2108431211 countsByYear W21084312112016 @default.
• W2108431211 countsByYear W21084312112017 @default.
• W2108431211 countsByYear W21084312112018 @default.
• W2108431211 countsByYear W21084312112019 @default.
• W2108431211 countsByYear W21084312112020 @default.
• W2108431211 countsByYear W21084312112021 @default.
• W2108431211 countsByYear W21084312112022 @default.
• W2108431211 countsByYear W21084312112023 @default.
• W2108431211 crossrefType "journal-article" @default.
• W2108431211 hasAuthorship W2108431211A5001711479 @default.
• W2108431211 hasAuthorship W2108431211A5003010633 @default.
• W2108431211 hasAuthorship W2108431211A5015680333 @default.
• W2108431211 hasAuthorship W2108431211A5029587764 @default.
• W2108431211 hasAuthorship W2108431211A5031500541 @default.
• W2108431211 hasAuthorship W2108431211A5042051260 @default.
• W2108431211 hasAuthorship W2108431211A5062464445 @default.
• W2108431211 hasAuthorship W2108431211A5079349599 @default.
• W2108431211 hasAuthorship W2108431211A5083914547 @default.
• W2108431211 hasBestOaLocation W21084312111 @default.
• W2108431211 hasConcept C126322002 @default.
• W2108431211 hasConcept C134018914 @default.
• W2108431211 hasConcept C178790620 @default.

• next