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• W2108431380 endingPage "67" @default.
• W2108431380 startingPage "57" @default.
• W2108431380 abstract "Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these is the early lytic viral G protein-coupled receptor (vGPCR), a homologue of the human interleukin-8 (IL-8) receptor. When expressed, vGPCR is constitutively active and can signal via mitogen- and stress-activated kinases. In certain models it activates the transcriptional potential of NF-kappaB and activator protein 1 (AP-1) and induces vascular endothelial growth factor (VEGF) production. Despite its importance to the pathogenesis of all KSHV-mediated disease, little is known about vGPCR activity in hematopoietic cells. To study the signaling potential and downstream effects of vGPCR in such cells, we have developed PEL cell lines that express vGPCR under the control of an inducible promoter. The sequences required for tetracycline-mediated induction were cloned into a plasmid containing adeno-associated virus type 2 elements to enhance integration efficiency. This novel plasmid permitted studies of vGPCR activity in naturally infected KSHV-positive lymphocytes. We show that vGPCR activates ERK-2 and p38 in PEL cells. In addition, it increases the transcription of reporter genes under the control of AP-1, NF-kappaB, CREB, and NFAT, a Ca(2+)-dependent transcription factor important to KSHV lytic gene expression. vGPCR also increases the transcription of KSHV open reading frames 50 and 57, thereby displaying broad potential to affect viral transcription patterns. Finally, vGPCR signaling results in increased PEL cell elaboration of KSHV vIL-6 and VEGF, two growth factors involved in KSHV-mediated disease pathogenesis." @default.
• W2108431380 created "2016-06-24" @default.
• W2108431380 creator A5015149811 @default.
• W2108431380 creator A5043795032 @default.
• W2108431380 creator A5065210718 @default.
• W2108431380 date "2003-01-01" @default.
• W2108431380 modified "2023-10-01" @default.
• W2108431380 title "The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells" @default.
• W2108431380 cites W1235745976 @default.
• W2108431380 cites W131938856 @default.
• W2108431380 cites W1483350500 @default.
• W2108431380 cites W1490724066 @default.
• W2108431380 cites W1504653733 @default.
• W2108431380 cites W1523189699 @default.
• W2108431380 cites W1548270485 @default.
• W2108431380 cites W1560653098 @default.
• W2108431380 cites W1570326358 @default.
• W2108431380 cites W1587318259 @default.
• W2108431380 cites W1635039246 @default.
• W2108431380 cites W1673584566 @default.
• W2108431380 cites W1712224666 @default.
• W2108431380 cites W1787380229 @default.
• W2108431380 cites W1975290731 @default.
• W2108431380 cites W1977560897 @default.
• W2108431380 cites W1981056903 @default.
• W2108431380 cites W1982047106 @default.
• W2108431380 cites W1984506063 @default.
• W2108431380 cites W1984992931 @default.
• W2108431380 cites W1988743962 @default.
• W2108431380 cites W2005275397 @default.
• W2108431380 cites W2007986629 @default.
• W2108431380 cites W2013739925 @default.
• W2108431380 cites W2018496509 @default.
• W2108431380 cites W2019190352 @default.
• W2108431380 cites W2021043660 @default.
• W2108431380 cites W2021065372 @default.
• W2108431380 cites W2026654302 @default.
• W2108431380 cites W2027230991 @default.
• W2108431380 cites W2028840705 @default.
• W2108431380 cites W2032438721 @default.
• W2108431380 cites W2040072356 @default.
• W2108431380 cites W2040998346 @default.
• W2108431380 cites W2044373921 @default.
• W2108431380 cites W2053631933 @default.
• W2108431380 cites W2055490337 @default.
• W2108431380 cites W2056841660 @default.
• W2108431380 cites W2064059449 @default.
• W2108431380 cites W2065537276 @default.
• W2108431380 cites W2067653648 @default.
• W2108431380 cites W2068307698 @default.
• W2108431380 cites W2074770401 @default.
• W2108431380 cites W2077416276 @default.
• W2108431380 cites W2078797418 @default.
• W2108431380 cites W2081481764 @default.
• W2108431380 cites W2081651119 @default.
• W2108431380 cites W2084842719 @default.
• W2108431380 cites W2089880838 @default.
• W2108431380 cites W2090639515 @default.
• W2108431380 cites W2091558286 @default.
• W2108431380 cites W2092965272 @default.
• W2108431380 cites W2096466927 @default.
• W2108431380 cites W2107445646 @default.
• W2108431380 cites W2108408806 @default.
• W2108431380 cites W2108486808 @default.
• W2108431380 cites W2120066089 @default.
• W2108431380 cites W2120542113 @default.
• W2108431380 cites W2121556311 @default.
• W2108431380 cites W2123045210 @default.
• W2108431380 cites W2124670069 @default.
• W2108431380 cites W2129591638 @default.
• W2108431380 cites W2136620152 @default.
• W2108431380 cites W2142890842 @default.
• W2108431380 cites W2143090686 @default.
• W2108431380 cites W2143909552 @default.
• W2108431380 cites W2149453948 @default.
• W2108431380 cites W2151468707 @default.
• W2108431380 cites W2153785468 @default.
• W2108431380 cites W2159163386 @default.
• W2108431380 cites W2160976310 @default.
• W2108431380 cites W2161636943 @default.
• W2108431380 cites W2166187451 @default.
• W2108431380 cites W2172235440 @default.
• W2108431380 cites W2257453531 @default.
• W2108431380 cites W2322523258 @default.
• W2108431380 cites W2327006078 @default.
• W2108431380 cites W2336241188 @default.
• W2108431380 cites W2410723119 @default.
• W2108431380 cites W2422910958 @default.
• W2108431380 cites W2431345963 @default.
• W2108431380 cites W3110836487 @default.
• W2108431380 cites W4245882686 @default.
• W2108431380 cites W4254732152 @default.
• W2108431380 cites W856065083 @default.
• W2108431380 doi "https://doi.org/10.1128/jvi.77.1.57-67.2003" @default.
• W2108431380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140579" @default.
• W2108431380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12477810" @default.
• W2108431380 hasPublicationYear "2003" @default.
• W2108431380 type Work @default.

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