FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108436842> ?p ?o ?g. }

• W2108436842 abstract "Recently our laboratory has reported, in a lacerated flexor tendon model, that the early turnover phase of the repair process extends for a longer period of time in vivo than previously documented. The extensive turnover of the collagenous matrix was consistent with the presence of collagenolytic activity in repairing tendon tissue and suggested a possible regulatory role for neutral metalloproteinases in flexor tendon repair. However, these in vivo observations could not distinguish the relative contribution by the tendon fibroblasts from that of the surrounding sheath and vascular tissue elements. To further define these interrelationships, the present study investigates the repair process of the flexor tendon in an in vitro tissue culture environment. The sequential changes in matrix formation were defined (i.e., proteoglycans/glycosaminoglycans, glycoproteins, and collagenous proteins). The concomitant production of neutral metalloproteinases as well as prostaglandin E2 was determined in relation to net tissue repair. Profundus flexor tendon segments were obtained from young adult Macaca nemestrina monkeys and maintained in organ culture for periods from 4 days through 9 weeks. Initially (at 2 wks) there was an increase in both sulfated and nonsulfated glycosaminoglycans, which preceded the onset of maximal collagen protein formation. By 6 and 9 weeks of in vitro repair, of the lacerated tendon segments, there was a significant increase in net collagen formation. Neutral metalloproteinase activity increased early in the repair period, from the 4th to 9th day, and decreased thereafter through the 9th week of culture. Functionally the enzyme appeared to be a gelatinase. The temporal pattern of in vitro collagen synthesis in relation to the gelatinase activity support the hypothesis that regulation of this enzyme(s) may be a critical factor in mediating the flexor tendon response to injury." @default.
• W2108436842 created "2016-06-24" @default.
• W2108436842 creator A5007164580 @default.
• W2108436842 creator A5085524011 @default.
• W2108436842 date "1989-01-01" @default.
• W2108436842 modified "2023-09-23" @default.
• W2108436842 title "Biochemical Evaluation of Organ Cultures from Primate Flexor Tendons" @default.
• W2108436842 cites W1510586846 @default.
• W2108436842 cites W1553158588 @default.
• W2108436842 cites W156099281 @default.
• W2108436842 cites W1882504833 @default.
• W2108436842 cites W1925296288 @default.
• W2108436842 cites W1953642784 @default.
• W2108436842 cites W1967395072 @default.
• W2108436842 cites W1978987630 @default.
• W2108436842 cites W1986678246 @default.
• W2108436842 cites W1989621744 @default.
• W2108436842 cites W1993101179 @default.
• W2108436842 cites W2027052280 @default.
• W2108436842 cites W2049822610 @default.
• W2108436842 cites W2052782072 @default.
• W2108436842 cites W2056174236 @default.
• W2108436842 cites W2064751784 @default.
• W2108436842 cites W2065858903 @default.
• W2108436842 cites W2070515477 @default.
• W2108436842 cites W2079831464 @default.
• W2108436842 cites W2084881631 @default.
• W2108436842 cites W2087539497 @default.
• W2108436842 cites W2100837269 @default.
• W2108436842 cites W2135001346 @default.
• W2108436842 cites W2199626136 @default.
• W2108436842 cites W2290224086 @default.
• W2108436842 cites W4297744189 @default.
• W2108436842 doi "https://doi.org/10.3109/03008208909103903" @default.
• W2108436842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2561090" @default.
• W2108436842 hasPublicationYear "1989" @default.
• W2108436842 type Work @default.
• W2108436842 sameAs 2108436842 @default.
• W2108436842 citedByCount "4" @default.
• W2108436842 countsByYear W21084368422014 @default.
• W2108436842 crossrefType "journal-article" @default.
• W2108436842 hasAuthorship W2108436842A5007164580 @default.
• W2108436842 hasAuthorship W2108436842A5085524011 @default.
• W2108436842 hasConcept C105702510 @default.
• W2108436842 hasConcept C106487976 @default.
• W2108436842 hasConcept C109523444 @default.
• W2108436842 hasConcept C126322002 @default.
• W2108436842 hasConcept C142724271 @default.
• W2108436842 hasConcept C150903083 @default.
• W2108436842 hasConcept C153074725 @default.
• W2108436842 hasConcept C181199279 @default.
• W2108436842 hasConcept C185592680 @default.
• W2108436842 hasConcept C202751555 @default.
• W2108436842 hasConcept C207001950 @default.
• W2108436842 hasConcept C2776232661 @default.
• W2108436842 hasConcept C2778394429 @default.
• W2108436842 hasConcept C2780105995 @default.
• W2108436842 hasConcept C28483552 @default.
• W2108436842 hasConcept C43617362 @default.
• W2108436842 hasConcept C55493867 @default.
• W2108436842 hasConcept C71924100 @default.
• W2108436842 hasConcept C86803240 @default.
• W2108436842 hasConcept C95444343 @default.
• W2108436842 hasConceptScore W2108436842C105702510 @default.
• W2108436842 hasConceptScore W2108436842C106487976 @default.
• W2108436842 hasConceptScore W2108436842C109523444 @default.
• W2108436842 hasConceptScore W2108436842C126322002 @default.
• W2108436842 hasConceptScore W2108436842C142724271 @default.
• W2108436842 hasConceptScore W2108436842C150903083 @default.
• W2108436842 hasConceptScore W2108436842C153074725 @default.
• W2108436842 hasConceptScore W2108436842C181199279 @default.
• W2108436842 hasConceptScore W2108436842C185592680 @default.
• W2108436842 hasConceptScore W2108436842C202751555 @default.
• W2108436842 hasConceptScore W2108436842C207001950 @default.
• W2108436842 hasConceptScore W2108436842C2776232661 @default.
• W2108436842 hasConceptScore W2108436842C2778394429 @default.
• W2108436842 hasConceptScore W2108436842C2780105995 @default.
• W2108436842 hasConceptScore W2108436842C28483552 @default.
• W2108436842 hasConceptScore W2108436842C43617362 @default.
• W2108436842 hasConceptScore W2108436842C55493867 @default.
• W2108436842 hasConceptScore W2108436842C71924100 @default.
• W2108436842 hasConceptScore W2108436842C86803240 @default.
• W2108436842 hasConceptScore W2108436842C95444343 @default.
• W2108436842 hasLocation W21084368421 @default.
• W2108436842 hasLocation W21084368422 @default.
• W2108436842 hasOpenAccess W2108436842 @default.
• W2108436842 hasPrimaryLocation W21084368421 @default.
• W2108436842 hasRelatedWork W1544176524 @default.
• W2108436842 hasRelatedWork W1556346237 @default.
• W2108436842 hasRelatedWork W1968333661 @default.
• W2108436842 hasRelatedWork W1976655006 @default.
• W2108436842 hasRelatedWork W1982828943 @default.
• W2108436842 hasRelatedWork W1991717790 @default.
• W2108436842 hasRelatedWork W2047041484 @default.
• W2108436842 hasRelatedWork W2070045583 @default.
• W2108436842 hasRelatedWork W2108436842 @default.
• W2108436842 hasRelatedWork W2395571333 @default.
• W2108436842 isParatext "false" @default.
• W2108436842 isRetracted "false" @default.
• W2108436842 magId "2108436842" @default.

• next