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• W2108447055 abstract "The superficial femoral artery has a 50–60% rate of repeat restenosis following revascularization for in stent restenosis. Radiation has been shown to prevent restenosis of the coronary arteries. Brachytherapy is generally used when irradiating the coronary arteries. Multiple systems are available for coronary artery brachytherapy. However, equipment for superficial femoral artery brachytherapy is not readily available. A protocol was developed to safely and effectively treat patients with external beam radiation in order to prevent repeat in-stent restenosis of the superficial femoral artery following revascularization. 18 patients with in-stent restenosis of the superficial femoral artery underwent angioplasty from June 2006 to October 2008. These patients were prospectively treated with 20 Gy in 5 equal fractions on nonconsecutive days delivered to the revascularized portion of the superficial femoral artery. Radiation was initiated on the day of revascularization and was delivered over 9 elapsed days. Three dimensional conformal treatment planning was performed to minimize irradiation of the femur and peripheral nerve. 3 of the 18 patients received radiation to both superficial femoral arteries. The need for in field revascularization of the superficial femoral artery 6 months following radiation treatment was the primary endpoint. Acute and late toxicity rates were secondary endpoints. 2 of the 18 patients required in field revascularization of the superficial femoral artery for restenosis following radiation at 6 and 11 months, respectively. The other 16 patients have not required in field revascularization of the superficial femoral artery at a mean follow-up of 13 months (range, 5–31 months). The rate of in field restenosis requiring revascularization at 6 months was 6%. Patients experienced no acute side effects due to radiation during the course of treatment. There was no late radiation toxicity. Our results indicate that external beam radiation is effective in preventing restenosis of the superficial femoral artery following revascularization for in-stent restenosis. The above protocol for radiation treatment of the superficial femoral artery appears to be safe and has entailed minimal toxicity. Further data will be needed to confirm the safety and efficacy of external beam radiation for the prevention of repeat in stent restenosis of the superficial femoral artery." @default.
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• W2108447055 date "2009-11-01" @default.
• W2108447055 modified "2023-09-27" @default.
• W2108447055 title "Radiation to Prevent In-stent Restenosis of the Superficial Femoral Artery" @default.
• W2108447055 doi "https://doi.org/10.1016/j.ijrobp.2009.07.1107" @default.
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