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- W2108456037 abstract "Objectives To assess the demographic and clinical findings of measles patients during three epidemics from 1989 to 2001. Methods A total 520 medical records of measles patients were analyzed retrospectively and divided into three groups; those who were admitted during 1989–1990 (group I, 116 patients), those admitted during 1993–1994 (group II, 127 patients), and those admitted during 2000–2001 (group III, 277 patients). Results For the age distribution, there was no difference in the proportion of <2 years of age (61%, 58% and 57%, respectively) for the three groups. However, in each outbreak, there were significant differences in the distribution of ≥2 years children who had mostly received one-dose measles–mumps–rubella (MMR) vaccination. The age distribution had changed with a significant increase in older children in subsequent outbreaks. In the last 2000–2001 outbreak, there was a pattern for increased attack rates with increasing interval since the initial vaccination. There was no statistical difference between the three groups in gender ratio, MMR vaccination rate in ≥2 years of age, duration of fever, and complications. No difference was found in all the clinical and laboratory parameters between the anti-measles IgM antibody negative patients and the positive patients. Conclusions The age distribution of admitted children with measles in each outbreak has changed over time since the introduction of one-dose MMR vaccination. This finding suggests that the secondary vaccine failure may have played a large role in the last measles outbreak." @default.
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- W2108456037 date "2007-02-01" @default.
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- W2108456037 title "The changing epidemiology of hospitalized pediatric patients in three measles outbreaks" @default.
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- W2108456037 doi "https://doi.org/10.1016/j.jinf.2006.02.016" @default.
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