Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108457618> ?p ?o ?g. }
- W2108457618 endingPage "294" @default.
- W2108457618 startingPage "284" @default.
- W2108457618 abstract "Species-specific lung tumors in the mouse are induced by a number of chemicals. The underlying cause appears to be a high metabolic activity of mouse lung, due to relatively high abundance of Clara cells in mice compared with humans and the mouse-specific cytochrome P450 isoform 2f2 in the Clara cells. The chemicals are activated to reactive intermediates, leading to local cytotoxicity or mitogenicity resulting in increased cell proliferation and tumors. Rats have lower metabolic activity than mice (already below the threshold needed to cause lung tumors upon lifetime exposure) and activity in humans is lower than in rats. The carcinogenic risk for human lung is low for this mode of action (MOA). Fluensulfone has shown an increased incidence of lung adenomas in mice, but not in rats, at high doses. Fluensulfone is not genotoxic. MOA studies were conducted investigating key events of the postulated MOA. Fluensulfone is extensively metabolized by mouse lung microsomes, whereas no metabolic activity is seen with human lung microsomes. Cyp 2f2 is a major contributor in fluensulfone’s metabolism and Cyp 2e1 is not involved. Furthermore, administration of fluensulfone to mice led to an early increase in Clara cell proliferation. The International Programme on Chemical Safety (IPCS) MOA and human relevance framework was used to evaluate the collective data on fluensulfone. We concluded that fluensulfone leads to species-specific mouse lung tumors and that these tumors are likely not relevant to human hazard or risk." @default.
- W2108457618 created "2016-06-24" @default.
- W2108457618 creator A5012116071 @default.
- W2108457618 creator A5014884664 @default.
- W2108457618 creator A5029395581 @default.
- W2108457618 creator A5049646465 @default.
- W2108457618 creator A5073137170 @default.
- W2108457618 creator A5079598935 @default.
- W2108457618 date "2012-04-05" @default.
- W2108457618 modified "2023-10-16" @default.
- W2108457618 title "Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors: Analysis of Their Human Relevance Using the IPCS Framework" @default.
- W2108457618 cites W1585986902 @default.
- W2108457618 cites W1758507682 @default.
- W2108457618 cites W1889419772 @default.
- W2108457618 cites W1908327267 @default.
- W2108457618 cites W1968129420 @default.
- W2108457618 cites W1974068770 @default.
- W2108457618 cites W1989879937 @default.
- W2108457618 cites W1997705859 @default.
- W2108457618 cites W2007739830 @default.
- W2108457618 cites W2008227339 @default.
- W2108457618 cites W2011460243 @default.
- W2108457618 cites W2014309206 @default.
- W2108457618 cites W2021095799 @default.
- W2108457618 cites W2024991413 @default.
- W2108457618 cites W2030606088 @default.
- W2108457618 cites W2034602546 @default.
- W2108457618 cites W2035816766 @default.
- W2108457618 cites W2045258678 @default.
- W2108457618 cites W2052954164 @default.
- W2108457618 cites W2070228974 @default.
- W2108457618 cites W2077858999 @default.
- W2108457618 cites W2096051625 @default.
- W2108457618 cites W2098995649 @default.
- W2108457618 cites W2105778324 @default.
- W2108457618 cites W2116023116 @default.
- W2108457618 cites W2120218695 @default.
- W2108457618 cites W2142971789 @default.
- W2108457618 cites W2146976723 @default.
- W2108457618 cites W2155491988 @default.
- W2108457618 cites W2158774960 @default.
- W2108457618 cites W2158777030 @default.
- W2108457618 cites W2167597551 @default.
- W2108457618 cites W2169806065 @default.
- W2108457618 cites W3023171543 @default.
- W2108457618 cites W4229791719 @default.
- W2108457618 cites W4255869374 @default.
- W2108457618 cites W4293247451 @default.
- W2108457618 doi "https://doi.org/10.1093/toxsci/kfs127" @default.
- W2108457618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3391030" @default.
- W2108457618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22491425" @default.
- W2108457618 hasPublicationYear "2012" @default.
- W2108457618 type Work @default.
- W2108457618 sameAs 2108457618 @default.
- W2108457618 citedByCount "20" @default.
- W2108457618 countsByYear W21084576182014 @default.
- W2108457618 countsByYear W21084576182015 @default.
- W2108457618 countsByYear W21084576182016 @default.
- W2108457618 countsByYear W21084576182017 @default.
- W2108457618 countsByYear W21084576182018 @default.
- W2108457618 countsByYear W21084576182019 @default.
- W2108457618 countsByYear W21084576182020 @default.
- W2108457618 countsByYear W21084576182021 @default.
- W2108457618 countsByYear W21084576182022 @default.
- W2108457618 countsByYear W21084576182023 @default.
- W2108457618 crossrefType "journal-article" @default.
- W2108457618 hasAuthorship W2108457618A5012116071 @default.
- W2108457618 hasAuthorship W2108457618A5014884664 @default.
- W2108457618 hasAuthorship W2108457618A5029395581 @default.
- W2108457618 hasAuthorship W2108457618A5049646465 @default.
- W2108457618 hasAuthorship W2108457618A5073137170 @default.
- W2108457618 hasAuthorship W2108457618A5079598935 @default.
- W2108457618 hasBestOaLocation W21084576181 @default.
- W2108457618 hasConcept C114246631 @default.
- W2108457618 hasConcept C121587506 @default.
- W2108457618 hasConcept C126322002 @default.
- W2108457618 hasConcept C134018914 @default.
- W2108457618 hasConcept C1491633281 @default.
- W2108457618 hasConcept C181199279 @default.
- W2108457618 hasConcept C190283241 @default.
- W2108457618 hasConcept C2777714996 @default.
- W2108457618 hasConcept C33070731 @default.
- W2108457618 hasConcept C502942594 @default.
- W2108457618 hasConcept C526171541 @default.
- W2108457618 hasConcept C55493867 @default.
- W2108457618 hasConcept C62112901 @default.
- W2108457618 hasConcept C62231903 @default.
- W2108457618 hasConcept C71924100 @default.
- W2108457618 hasConcept C86803240 @default.
- W2108457618 hasConcept C87644729 @default.
- W2108457618 hasConcept C98274493 @default.
- W2108457618 hasConceptScore W2108457618C114246631 @default.
- W2108457618 hasConceptScore W2108457618C121587506 @default.
- W2108457618 hasConceptScore W2108457618C126322002 @default.
- W2108457618 hasConceptScore W2108457618C134018914 @default.
- W2108457618 hasConceptScore W2108457618C1491633281 @default.
- W2108457618 hasConceptScore W2108457618C181199279 @default.
- W2108457618 hasConceptScore W2108457618C190283241 @default.