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• W2108458500 abstract "Abstract Saccharomyces cerevisiae cells enter into the G0-like resting state, stationary phase, in response to specific types of nutrient limitation. We have initiated a genetic analysis of this resting state and have identified a collection of rye mutants that exhibit a defective transcriptional response to nutrient deprivation. These transcriptional defects appear to disrupt the control of normal growth because the rye mutants are unable to enter into a normal stationary phase upon nutrient deprivation. In this study, we examined the mutants in the rye1 complementation group and found that rye1 mutants were also defective for stationary phase entry. Interestingly, the RYE1 gene was found to be identical to SIN4, a gene that encodes a component of the yeast Mediator complex within the RNA polymerase II holoenzyme. Moreover, mutations that affected proteins within the Sin4p module of the Mediator exhibited specific genetic interactions with the Ras protein signaling pathway. For example, mutations that elevated the levels of Ras signaling, like RAS2val19, were synthetic lethal with sin4. In all, our data suggest that specific proteins within the RNA polymerase II holoenzyme might be targets of signal transduction pathways that are responsible for coordinating gene expression with cell growth." @default.
• W2108458500 created "2016-06-24" @default.
• W2108458500 creator A5014707802 @default.
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• W2108458500 date "2001-09-01" @default.
• W2108458500 modified "2023-10-14" @default.
• W2108458500 title "The Ras/PKA Signaling Pathway of <i>Saccharomyces cerevisiae</i> Exhibits a Functional Interaction With the Sin4p Complex of the RNA Polymerase II Holoenzyme" @default.
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• W2108458500 doi "https://doi.org/10.1093/genetics/159.1.77" @default.
• W2108458500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461800" @default.
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• W2108458500 hasPublicationYear "2001" @default.
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