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- W2108459105 abstract "Background: Triaging of patients with chest pain in the emergency department is costly and time consuming. Human fatty acid binding protein is an emerging biomarker which is known to be sensitive marker of early myocardial cell injury. We prospectively investigated the usefulness of serial Human Fatty Acid Binding Protein determination in the evaluation of acute chest pain in patients arriving at the emergency department. Methods: In 47 consecutive patients who had acute chest pain for less than 12 hours without electrocardiographic changes and initial negative troponin elevation, serial human fatty acid binding protein was determined. Testing was performed at enrollment and 1 hour later using a point-of-care assay. Serial troponin determination and ischemia workup with stress testing was performed according to standard protocols. Results: Human fatty acid binding protein was positive in 7/47 (14.9%) patients while troponin was positive in 4 (8.5%) patients. There were 2/47 (4.3%) patients with angiographically significant stenosis. The sensitivity and specificity of human fatty acid binding protein was 75% and 83.7%, respectively compared to serial troponin measurement. The positive and negative predictive value of human fatty acid binding protein was 30% and 93.3%, respectively. The diagnostic accuracy was 82.9%. Conclusion: Point-of-care serial human fatty acid binding protein testing for early detection of myocardial cell injury has inferior diagnostic performance compared to serial troponin determination. The addition of human fatty acid binding protein measurement to troponin did not improve the diagnostic performance of troponin. Further assay validation and a larger study cohort is required to confirm these findings." @default.
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- W2108459105 date "2011-01-01" @default.
- W2108459105 modified "2023-09-27" @default.
- W2108459105 title "Rapid Assessment and Triaging of Acute Chest Pain Patients Using Human Fatty Acid Binding Protein (the RASTA study): Are we ready for prime time?" @default.
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- W2108459105 doi "https://doi.org/10.4172/2155-9880.1000119" @default.
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