FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108462008> ?p ?o ?g. }

• W2108462008 endingPage "1092" @default.
• W2108462008 startingPage "1075" @default.
• W2108462008 abstract "A model for immunologically T cell-mediated hepatitis was established in mice infected with lymphocytic choriomeningitis virus (LCMV). The severity of hepatitis was monitored histologically and by determination of changes in serum levels of the enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH), and alkaline phosphatase (AP). Kinetics of histological disease manifestations, increases of liver enzyme levels in the serum, and cytotoxic T cell activities in livers and spleens all correlated and were dependent upon several parameters: LCMV-isolate; LCMV-WE caused extensive hepatitis, LCMV-Armstrong virtually none. Virus dose. Route of infection; i.v. or i.p. infection caused hepatitis, whereas infection into the footpad did not. The general genetic background of the murine host; of the strains tested, Swiss mice and A-strain mice were more susceptible than C57BL or CBA mice; BALB/c and DBA/2 mice were least susceptible. The degree of immunocompetence of the murine host; T cell deficient nu/nu mice never developed hepatitis, whereas nu/+ or +/+ mice always did. B cell-depleted anti-IgM-treated mice developed immune-mediated hepatitis comparably or even more extensively than control mice. Local cytotoxic T cell activity; mononuclear cells isolated from livers during the period of overt hepatitis were two to five times more active than equal numbers of spleen cells. Adoptive transfer of nylon wool-nonadherent anti-Thy-1.2 and anti-Lyt-2 plus C-sensitive, anti-L3T4 plus C-resistant lymphocytes into irradiated mice preinfected with LCMV-WE caused a rapid time- and dose-dependent linear increase of serum enzyme levels. This increase was caused by adoptive transfer of lymphocytes if immune cell donors and recipient mice shared class I, but not when they shared class II histocompatibility antigens. The donor cell dose-dependent increase of these enzymes was first measurable 6-18 h after transfer with 2 X 10(8) cells or 3 X 10(6) cells, respectively. The time-dependent increase caused by the adoptive transfer of 1-2 X 10(8) cells was strictly linear during a period of up to 25-40 h. These results indicate single-hit kinetics of liver cell death and suggest that effector T cells destroy infected liver cells via direct contact rather than via soluble toxic mediators. The results may represent the best in vivo correlate of the in vitro 51Cr-release assay that has been analyzed so far, and strongly support the view that antiviral cytotoxic T cells are directly cytolytic in vivo.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2108462008 created "2016-06-24" @default.
• W2108462008 creator A5009783885 @default.
• W2108462008 creator A5015933246 @default.
• W2108462008 creator A5017348835 @default.
• W2108462008 creator A5023755077 @default.
• W2108462008 creator A5058643917 @default.
• W2108462008 creator A5089051946 @default.
• W2108462008 date "1986-10-01" @default.
• W2108462008 modified "2023-10-09" @default.
• W2108462008 title "T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?" @default.
• W2108462008 cites W146626956 @default.
• W2108462008 cites W1555565172 @default.
• W2108462008 cites W1564309137 @default.
• W2108462008 cites W1568336135 @default.
• W2108462008 cites W1677464321 @default.
• W2108462008 cites W1707380850 @default.
• W2108462008 cites W1762060580 @default.
• W2108462008 cites W1935665537 @default.
• W2108462008 cites W1968039269 @default.
• W2108462008 cites W1968560825 @default.
• W2108462008 cites W1968800495 @default.
• W2108462008 cites W1969121427 @default.
• W2108462008 cites W1972689404 @default.
• W2108462008 cites W1974287203 @default.
• W2108462008 cites W1984353602 @default.
• W2108462008 cites W2008283599 @default.
• W2108462008 cites W2009598375 @default.
• W2108462008 cites W2025745949 @default.
• W2108462008 cites W2035195082 @default.
• W2108462008 cites W2039198049 @default.
• W2108462008 cites W2048275523 @default.
• W2108462008 cites W2049949206 @default.
• W2108462008 cites W2053416744 @default.
• W2108462008 cites W2060759598 @default.
• W2108462008 cites W2072210000 @default.
• W2108462008 cites W2084093106 @default.
• W2108462008 cites W2119997031 @default.
• W2108462008 cites W2120515517 @default.
• W2108462008 cites W2147406474 @default.
• W2108462008 cites W2150429488 @default.
• W2108462008 cites W2162032607 @default.
• W2108462008 cites W2164028234 @default.
• W2108462008 cites W2213538010 @default.
• W2108462008 cites W2287324627 @default.
• W2108462008 cites W2394980262 @default.
• W2108462008 cites W2410622602 @default.
• W2108462008 cites W2411884970 @default.
• W2108462008 cites W275516703 @default.
• W2108462008 cites W40843633 @default.
• W2108462008 cites W7989439 @default.
• W2108462008 doi "https://doi.org/10.1084/jem.164.4.1075" @default.
• W2108462008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188412" @default.
• W2108462008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3489805" @default.
• W2108462008 hasPublicationYear "1986" @default.
• W2108462008 type Work @default.
• W2108462008 sameAs 2108462008 @default.
• W2108462008 citedByCount "201" @default.
• W2108462008 countsByYear W21084620082012 @default.
• W2108462008 countsByYear W21084620082013 @default.
• W2108462008 countsByYear W21084620082014 @default.
• W2108462008 countsByYear W21084620082015 @default.
• W2108462008 countsByYear W21084620082016 @default.
• W2108462008 countsByYear W21084620082017 @default.
• W2108462008 countsByYear W21084620082018 @default.
• W2108462008 countsByYear W21084620082019 @default.
• W2108462008 countsByYear W21084620082020 @default.
• W2108462008 countsByYear W21084620082021 @default.
• W2108462008 countsByYear W21084620082022 @default.
• W2108462008 countsByYear W21084620082023 @default.
• W2108462008 crossrefType "journal-article" @default.
• W2108462008 hasAuthorship W2108462008A5009783885 @default.
• W2108462008 hasAuthorship W2108462008A5015933246 @default.
• W2108462008 hasAuthorship W2108462008A5017348835 @default.
• W2108462008 hasAuthorship W2108462008A5023755077 @default.
• W2108462008 hasAuthorship W2108462008A5058643917 @default.
• W2108462008 hasAuthorship W2108462008A5089051946 @default.
• W2108462008 hasBestOaLocation W21084620081 @default.
• W2108462008 hasConcept C153911025 @default.
• W2108462008 hasConcept C154317977 @default.
• W2108462008 hasConcept C159047783 @default.
• W2108462008 hasConcept C167672396 @default.
• W2108462008 hasConcept C202751555 @default.
• W2108462008 hasConcept C203014093 @default.
• W2108462008 hasConcept C2522874641 @default.
• W2108462008 hasConcept C2776029263 @default.
• W2108462008 hasConcept C2776090121 @default.
• W2108462008 hasConcept C2780190958 @default.
• W2108462008 hasConcept C2780931953 @default.
• W2108462008 hasConcept C55493867 @default.
• W2108462008 hasConcept C86803240 @default.
• W2108462008 hasConcept C8891405 @default.
• W2108462008 hasConcept C90375314 @default.
• W2108462008 hasConceptScore W2108462008C153911025 @default.
• W2108462008 hasConceptScore W2108462008C154317977 @default.
• W2108462008 hasConceptScore W2108462008C159047783 @default.
• W2108462008 hasConceptScore W2108462008C167672396 @default.
• W2108462008 hasConceptScore W2108462008C202751555 @default.

• next