FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108474711> ?p ?o ?g. }

• W2108474711 endingPage "2807" @default.
• W2108474711 startingPage "2797" @default.
• W2108474711 abstract "Abstract Prion diseases are fatal neurodegenerative diseases that are characterized by the conformational conversion of the normal, mainly α-helical cellular prion protein (PrP) into the abnormal β-sheet-rich infectious isoform (PrPSc). The immune system neither shows reaction against cellular PrP nor PrPSc, most likely due to profound self-tolerance. In previous studies, we were able to partly overcome self-tolerance using recombinantly expressed dimeric PrP (tandem PrP (tPrP)), in association with different adjuvants. Proof of principle for antiprion efficacy was obtained in vitro and in vivo. In this study, we demonstrate the induction of a specific Th1 T cell response in wild-type mice immunized with tPrP and CpG-oligonucleotide (ODN). Biochemical influences such as refolding conditions, ionic strength, pH, and interaction with CpG-ODN affected antigenic structure and thus improved immunogenicity. Furthermore, s.c. immunization with tPrP and CpG-ODN coencapsulated in biodegradable polylactide-coglycolide microspheres (PLGA-MS) enhanced CD4 T cell responses and, more prominent, the induction of CD8 T cells. In this vaccination protocol, PLGA-MS function as endosomal delivery device of Ag plus CpG-ODN to macrophages and dendritic cells. In contrast, PLGA-MS-based DNA vaccination approaches with a tPrP construct generated poor humoral and T cell responses. Our data show that prophylactic and therapeutic immunization approaches against prion infections might be feasible using tPrP Ag and CpG-ODN adjuvant without detectable side effects." @default.
• W2108474711 created "2016-06-24" @default.
• W2108474711 creator A5027069303 @default.
• W2108474711 creator A5029333060 @default.
• W2108474711 creator A5033121718 @default.
• W2108474711 creator A5041791584 @default.
• W2108474711 creator A5046981639 @default.
• W2108474711 creator A5050143301 @default.
• W2108474711 creator A5062319803 @default.
• W2108474711 creator A5079497279 @default.
• W2108474711 creator A5091707109 @default.
• W2108474711 date "2007-09-01" @default.
• W2108474711 modified "2023-10-16" @default.
• W2108474711 title "Polylactide-Coglycolide Microspheres CoEncapsulating Recombinant Tandem Prion Protein with CpG-Oligonucleotide Break Self-Tolerance to Prion Protein in Wild-Type Mice and Induce CD4 and CD8 T Cell Responses" @default.
• W2108474711 cites W103986698 @default.
• W2108474711 cites W1501494207 @default.
• W2108474711 cites W1529870582 @default.
• W2108474711 cites W1601881612 @default.
• W2108474711 cites W1744745958 @default.
• W2108474711 cites W1757613141 @default.
• W2108474711 cites W1939858431 @default.
• W2108474711 cites W1966387114 @default.
• W2108474711 cites W1978525961 @default.
• W2108474711 cites W1986196133 @default.
• W2108474711 cites W1991211881 @default.
• W2108474711 cites W1991993391 @default.
• W2108474711 cites W1993820504 @default.
• W2108474711 cites W1997276741 @default.
• W2108474711 cites W1998063109 @default.
• W2108474711 cites W2003419081 @default.
• W2108474711 cites W2003972698 @default.
• W2108474711 cites W2007093034 @default.
• W2108474711 cites W2007372075 @default.
• W2108474711 cites W2007967965 @default.
• W2108474711 cites W2012405730 @default.
• W2108474711 cites W2013060628 @default.
• W2108474711 cites W2013679718 @default.
• W2108474711 cites W2019455863 @default.
• W2108474711 cites W2020134215 @default.
• W2108474711 cites W2021896470 @default.
• W2108474711 cites W2022118976 @default.
• W2108474711 cites W2022581009 @default.
• W2108474711 cites W2033752086 @default.
• W2108474711 cites W2033796334 @default.
• W2108474711 cites W2036594163 @default.
• W2108474711 cites W2038260181 @default.
• W2108474711 cites W2042978244 @default.
• W2108474711 cites W2046137696 @default.
• W2108474711 cites W2058156110 @default.
• W2108474711 cites W2059884673 @default.
• W2108474711 cites W2063553621 @default.
• W2108474711 cites W2070803308 @default.
• W2108474711 cites W2072303997 @default.
• W2108474711 cites W2074121683 @default.
• W2108474711 cites W2077343536 @default.
• W2108474711 cites W2078646954 @default.
• W2108474711 cites W2080105559 @default.
• W2108474711 cites W2088527507 @default.
• W2108474711 cites W2089604827 @default.
• W2108474711 cites W2089735758 @default.
• W2108474711 cites W2093394063 @default.
• W2108474711 cites W2093508027 @default.
• W2108474711 cites W2095789660 @default.
• W2108474711 cites W2095851154 @default.
• W2108474711 cites W2110467505 @default.
• W2108474711 cites W2110946337 @default.
• W2108474711 cites W2113792335 @default.
• W2108474711 cites W2118011548 @default.
• W2108474711 cites W2124153796 @default.
• W2108474711 cites W2124342403 @default.
• W2108474711 cites W2141409843 @default.
• W2108474711 cites W2145808628 @default.
• W2108474711 cites W2147703009 @default.
• W2108474711 cites W2154936868 @default.
• W2108474711 cites W2159169254 @default.
• W2108474711 cites W2162242622 @default.
• W2108474711 cites W2163981524 @default.
• W2108474711 cites W2167517570 @default.
• W2108474711 cites W2170957124 @default.
• W2108474711 cites W2324660492 @default.
• W2108474711 doi "https://doi.org/10.4049/jimmunol.179.5.2797" @default.
• W2108474711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17709493" @default.
• W2108474711 hasPublicationYear "2007" @default.
• W2108474711 type Work @default.
• W2108474711 sameAs 2108474711 @default.
• W2108474711 citedByCount "49" @default.
• W2108474711 countsByYear W21084747112012 @default.
• W2108474711 countsByYear W21084747112013 @default.
• W2108474711 countsByYear W21084747112014 @default.
• W2108474711 countsByYear W21084747112015 @default.
• W2108474711 countsByYear W21084747112016 @default.
• W2108474711 countsByYear W21084747112017 @default.
• W2108474711 countsByYear W21084747112018 @default.
• W2108474711 countsByYear W21084747112019 @default.
• W2108474711 countsByYear W21084747112020 @default.
• W2108474711 countsByYear W21084747112021 @default.
• W2108474711 countsByYear W21084747112022 @default.
• W2108474711 countsByYear W21084747112023 @default.

• next