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- W2108476871 abstract "The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyazatadine, were isolated by high-performance liquid chromatography and characterized by mass spectrometric and proton nuclear magnetic resonance spectroscopic analyses." @default.
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- W2108476871 date "1996-09-01" @default.
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- W2108476871 title "Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans" @default.
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- W2108476871 doi "https://doi.org/10.1128/aem.62.9.3477-3479.1996" @default.
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