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- W2108477112 abstract "Only a few methods permit researchers to study selected regions of the central and peripheral nervous systems with a spatial and time resolution sufficient to image the function of neural structures. Usually, these methods cannot analyse deep-brain regions and a high-resolution method, which could repeatedly probe dynamic processes in any region of the central and peripheral nervous systems, is much needed. Here, we show that fibred fluorescence microscopy-which uses a small-diameter fibre-optic probe to provide real-time images-has the spatial resolution to image various neural structures in the living animal, the consistency needed for a sequential, quantitative evaluation of axonal degeneration/regeneration of a peripheral nerve, and the sensitivity to detect calcium transients on a sub-second timescale. These unique features should prove useful in many physiological studies requiring the in situ functional imaging of tissues in a living animal." @default.
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- W2108477112 date "2006-09-29" @default.
- W2108477112 modified "2023-10-16" @default.
- W2108477112 title "Live imaging of neural structure and function by fibred fluorescence microscopy" @default.
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- W2108477112 doi "https://doi.org/10.1038/sj.embor.7400801" @default.
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