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- W2108478376 abstract "The TOR protein kinases (TOR1 and TOR2 in yeast; mTOR/FRAP/RAFT1 in mammals) promote cellular proliferation in response to nutrients and growth factors, but their role in development is poorly understood. Here, we show that the Drosophila TOR homolog dTOR is required cell autonomously for normal growth and proliferation during larval development, and for increases in cellular growth caused by activation of the phosphoinositide 3-kinase (PI3K) signaling pathway. As in mammalian cells, the kinase activity of dTOR is required for growth factor-dependent phosphorylation of p70 S6 kinase (p70(S6K)) in vitro, and we demonstrate that overexpression of p70(S6K) in vivo can rescue dTOR mutant animals to viability. Loss of dTOR also results in cellular phenotypes characteristic of amino acid deprivation, including reduced nucleolar size, lipid vesicle aggregation in the larval fat body, and a cell type-specific pattern of cell cycle arrest that can be bypassed by overexpression of the S-phase regulator cyclin E. Our results suggest that dTOR regulates growth during animal development by coupling growth factor signaling to nutrient availability." @default.
- W2108478376 created "2016-06-24" @default.
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- W2108478376 date "2000-11-01" @default.
- W2108478376 modified "2023-10-03" @default.
- W2108478376 title "Regulation of cellular growth by the <i>Drosophila</i> target of rapamycin <i>dTOR</i>" @default.
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- W2108478376 cites W1614347411 @default.
- W2108478376 cites W1840303083 @default.
- W2108478376 cites W1909702956 @default.
- W2108478376 cites W1911968642 @default.
- W2108478376 cites W1939431494 @default.
- W2108478376 cites W1968676663 @default.
- W2108478376 cites W1969134022 @default.
- W2108478376 cites W1974022382 @default.
- W2108478376 cites W1974037176 @default.
- W2108478376 cites W1978666863 @default.
- W2108478376 cites W1979612739 @default.
- W2108478376 cites W1983566498 @default.
- W2108478376 cites W1987339939 @default.
- W2108478376 cites W1989461823 @default.
- W2108478376 cites W1993836723 @default.
- W2108478376 cites W1994644266 @default.
- W2108478376 cites W2000281583 @default.
- W2108478376 cites W2005188492 @default.
- W2108478376 cites W2006932987 @default.
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- W2108478376 cites W2010379212 @default.
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- W2108478376 cites W2086899319 @default.
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- W2108478376 doi "https://doi.org/10.1101/gad.835000" @default.
- W2108478376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/317034" @default.
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