FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108481106> ?p ?o ?g. }

• W2108481106 endingPage "1399" @default.
• W2108481106 startingPage "1391" @default.
• W2108481106 abstract "Abstract Background Serum hepcidin concentration is potentially affected by inflammation and iron stores in chronic liver disease ( CLD ), but little is known about the relationship between hepcidin and the degree of hepatic fibrosis. We investigated the potential role of serum hepcidin as a biomarker of advanced liver disease. Methods Serum hepcidin was measured in 332 adults with CLD of varying aetiologies, 45 healthy and 50 non‐liver disease patient controls. Liver biopsy data were available for 228 CLD subjects. Results Hepcidin was decreased in CLD patients compared with non‐liver disease patient controls ( P < 0.0001) but not healthy controls, and was lowest in those with cirrhosis ( P < 0.0001). Serum hepcidin correlated with hepatic hepcidin mRNA expression in 91 biopsy samples available for genetic analysis ( r = 0.68, P < 0.0001). Hepcidin also correlated positively with serum ferritin concentration, transferrin saturation, ALT , serum albumin and haemoglobin, but negatively with serum bilirubin. The hepcidin:ferritin ratio was significantly lower in CLD subjects compared with healthy and disease controls, and decreased with each increase in the stage of fibrosis and siderosis. The hepcidin:ferritin ratio was associated with progressive fibrosis on linear regression, and a value of less than 0.1 was independently associated with cirrhosis on logistic regression analyses ( OR 5.54, P < 0.001). Receiver operating characteristic analysis showed the hepcidin:ferritin ratio was able to distinguish between F 0 and F 4 stages of fibrosis (area under receiver operating characteristic curve = 0.86). Conclusions The hepcidin:ferritin ratio is reduced in relation to increasing fibrosis in CLD and the use of this ratio may have potential future diagnostic implications as a marker of cirrhosis." @default.
• W2108481106 created "2016-06-24" @default.
• W2108481106 creator A5002794175 @default.
• W2108481106 creator A5008922637 @default.
• W2108481106 creator A5021823784 @default.
• W2108481106 creator A5038107882 @default.
• W2108481106 creator A5041423104 @default.
• W2108481106 creator A5043806394 @default.
• W2108481106 creator A5049080250 @default.
• W2108481106 creator A5087176957 @default.
• W2108481106 creator A5087942898 @default.
• W2108481106 date "2012-06-07" @default.
• W2108481106 modified "2023-10-17" @default.
• W2108481106 title "The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis" @default.
• W2108481106 cites W1901626724 @default.
• W2108481106 cites W1967025395 @default.
• W2108481106 cites W1970739518 @default.
• W2108481106 cites W1974190945 @default.
• W2108481106 cites W1980042430 @default.
• W2108481106 cites W1992239176 @default.
• W2108481106 cites W1994522422 @default.
• W2108481106 cites W1997977268 @default.
• W2108481106 cites W2003478281 @default.
• W2108481106 cites W2010494523 @default.
• W2108481106 cites W2025063713 @default.
• W2108481106 cites W2027624389 @default.
• W2108481106 cites W2037674164 @default.
• W2108481106 cites W2037708841 @default.
• W2108481106 cites W2045728460 @default.
• W2108481106 cites W2050364585 @default.
• W2108481106 cites W2067740038 @default.
• W2108481106 cites W2073843577 @default.
• W2108481106 cites W2084782463 @default.
• W2108481106 cites W2091491906 @default.
• W2108481106 cites W2094174828 @default.
• W2108481106 cites W2095075233 @default.
• W2108481106 cites W2098622034 @default.
• W2108481106 cites W2109945939 @default.
• W2108481106 cites W2119240491 @default.
• W2108481106 cites W2124500066 @default.
• W2108481106 cites W2130613991 @default.
• W2108481106 cites W2144753011 @default.
• W2108481106 cites W2145686528 @default.
• W2108481106 cites W2159886045 @default.
• W2108481106 cites W2165980043 @default.
• W2108481106 cites W4211166276 @default.
• W2108481106 cites W4255208521 @default.
• W2108481106 cites W8890124 @default.
• W2108481106 doi "https://doi.org/10.1111/j.1478-3231.2012.02828.x" @default.
• W2108481106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22676252" @default.
• W2108481106 hasPublicationYear "2012" @default.
• W2108481106 type Work @default.
• W2108481106 sameAs 2108481106 @default.
• W2108481106 citedByCount "57" @default.
• W2108481106 countsByYear W21084811062013 @default.
• W2108481106 countsByYear W21084811062014 @default.
• W2108481106 countsByYear W21084811062015 @default.
• W2108481106 countsByYear W21084811062016 @default.
• W2108481106 countsByYear W21084811062017 @default.
• W2108481106 countsByYear W21084811062018 @default.
• W2108481106 countsByYear W21084811062019 @default.
• W2108481106 countsByYear W21084811062020 @default.
• W2108481106 countsByYear W21084811062021 @default.
• W2108481106 countsByYear W21084811062022 @default.
• W2108481106 countsByYear W21084811062023 @default.
• W2108481106 crossrefType "journal-article" @default.
• W2108481106 hasAuthorship W2108481106A5002794175 @default.
• W2108481106 hasAuthorship W2108481106A5008922637 @default.
• W2108481106 hasAuthorship W2108481106A5021823784 @default.
• W2108481106 hasAuthorship W2108481106A5038107882 @default.
• W2108481106 hasAuthorship W2108481106A5041423104 @default.
• W2108481106 hasAuthorship W2108481106A5043806394 @default.
• W2108481106 hasAuthorship W2108481106A5049080250 @default.
• W2108481106 hasAuthorship W2108481106A5087176957 @default.
• W2108481106 hasAuthorship W2108481106A5087942898 @default.
• W2108481106 hasConcept C126322002 @default.
• W2108481106 hasConcept C134018914 @default.
• W2108481106 hasConcept C153852466 @default.
• W2108481106 hasConcept C185592680 @default.
• W2108481106 hasConcept C2776768029 @default.
• W2108481106 hasConcept C2776914184 @default.
• W2108481106 hasConcept C2777075537 @default.
• W2108481106 hasConcept C2777214474 @default.
• W2108481106 hasConcept C2778248108 @default.
• W2108481106 hasConcept C2778319317 @default.
• W2108481106 hasConcept C2779875672 @default.
• W2108481106 hasConcept C2780559512 @default.
• W2108481106 hasConcept C2781197716 @default.
• W2108481106 hasConcept C3019184707 @default.
• W2108481106 hasConcept C55493867 @default.
• W2108481106 hasConcept C71924100 @default.
• W2108481106 hasConcept C76318530 @default.
• W2108481106 hasConcept C90924648 @default.
• W2108481106 hasConceptScore W2108481106C126322002 @default.
• W2108481106 hasConceptScore W2108481106C134018914 @default.
• W2108481106 hasConceptScore W2108481106C153852466 @default.
• W2108481106 hasConceptScore W2108481106C185592680 @default.
• W2108481106 hasConceptScore W2108481106C2776768029 @default.

• next