FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108485802> ?p ?o ?g. }

• W2108485802 endingPage "524" @default.
• W2108485802 startingPage "517" @default.
• W2108485802 abstract "Our introductory pig-to-cynomolgus monkey heart or kidney transplantation using organs from pigs transgenic for human decay-accelerating factor (hDAF), showed a high incidence of hyperacute rejection (HAR), which was ascribed to extraordinary high levels of anti-pig antibodies. We evaluated the efficacy of GAS914, a Gal alpha 1-3Gal trisaccharide linked to a poly-l-lysine backbone, in inhibition of HAR.hDAF transgenic heterotopic heart (n = 15) or life-supporting kidney (n = 8) transplantation included induction with cyclophosphamide or anti-thymocyte globulin, and maintenance with cyclosporine or tacrolimus, steroids and mycophenolate sodium/mofetil. Four doses of GAS914 were given before transplantation. Rejection was confirmed by graft histology, and anti-pig antibody levels were determined in various assays.Four of six heart transplants without GAS914 treatment showed HAR. Nine subsequent transplants with GAS914 pre-treatment, did not show HAR (chi-square, P < 0.05). Two of four kidney transplants without GAS914 treatment ended with HAR. Four subsequent transplants with GAS914 did not show HAR. Animals with HAR showed extremely high antibody levels. Samples just before transplantation showed significantly higher antibody levels in recipients presenting with HAR. In all assays antibody levels were significantly lowered by GAS914 pre-treatment.HAR of hDAF solid organs could be ascribed to high levels of anti-pig antibodies. It is hypothesized that the hDAF transgene shows a threshold in efficacy, above which an overwhelming attack by antibodies and complement activation cannot be modulated to prevent HAR. HAR does not occur when animals with lower levels are used, or when antibodies are effectively depleted from the circulation by GAS914 treatment." @default.
• W2108485802 created "2016-06-24" @default.
• W2108485802 creator A5003215527 @default.
• W2108485802 creator A5003985388 @default.
• W2108485802 creator A5004063560 @default.
• W2108485802 creator A5007589378 @default.
• W2108485802 creator A5012754330 @default.
• W2108485802 creator A5013503310 @default.
• W2108485802 creator A5029415378 @default.
• W2108485802 creator A5031195893 @default.
• W2108485802 creator A5036077555 @default.
• W2108485802 creator A5038378075 @default.
• W2108485802 creator A5045672031 @default.
• W2108485802 creator A5047149967 @default.
• W2108485802 creator A5049232814 @default.
• W2108485802 creator A5054247350 @default.
• W2108485802 creator A5088941214 @default.
• W2108485802 date "2004-10-08" @default.
• W2108485802 modified "2023-10-10" @default.
• W2108485802 title "Hyperacute rejection of hDAF-transgenic pig organ xenografts in cynomolgus monkeys: influence of pre-existing anti-pig antibodies and prevention by the alphaGAL glycoconjugate GAS914" @default.
• W2108485802 cites W1975529617 @default.
• W2108485802 cites W1981275517 @default.
• W2108485802 cites W1994071925 @default.
• W2108485802 cites W2031058011 @default.
• W2108485802 cites W2042303293 @default.
• W2108485802 cites W2045790927 @default.
• W2108485802 cites W2048492674 @default.
• W2108485802 cites W2064486602 @default.
• W2108485802 cites W2071943691 @default.
• W2108485802 cites W2087878647 @default.
• W2108485802 cites W2091668530 @default.
• W2108485802 cites W2101043709 @default.
• W2108485802 cites W2118847407 @default.
• W2108485802 cites W2119511781 @default.
• W2108485802 cites W2133785873 @default.
• W2108485802 cites W2140699817 @default.
• W2108485802 cites W2146092834 @default.
• W2108485802 cites W2147028712 @default.
• W2108485802 cites W2158558790 @default.
• W2108485802 cites W2161094602 @default.
• W2108485802 cites W4251829470 @default.
• W2108485802 doi "https://doi.org/10.1111/j.1399-3089.2004.00173.x" @default.
• W2108485802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15479461" @default.
• W2108485802 hasPublicationYear "2004" @default.
• W2108485802 type Work @default.
• W2108485802 sameAs 2108485802 @default.
• W2108485802 citedByCount "20" @default.
• W2108485802 countsByYear W21084858022014 @default.
• W2108485802 countsByYear W21084858022015 @default.
• W2108485802 crossrefType "journal-article" @default.
• W2108485802 hasAuthorship W2108485802A5003215527 @default.
• W2108485802 hasAuthorship W2108485802A5003985388 @default.
• W2108485802 hasAuthorship W2108485802A5004063560 @default.
• W2108485802 hasAuthorship W2108485802A5007589378 @default.
• W2108485802 hasAuthorship W2108485802A5012754330 @default.
• W2108485802 hasAuthorship W2108485802A5013503310 @default.
• W2108485802 hasAuthorship W2108485802A5029415378 @default.
• W2108485802 hasAuthorship W2108485802A5031195893 @default.
• W2108485802 hasAuthorship W2108485802A5036077555 @default.
• W2108485802 hasAuthorship W2108485802A5038378075 @default.
• W2108485802 hasAuthorship W2108485802A5045672031 @default.
• W2108485802 hasAuthorship W2108485802A5047149967 @default.
• W2108485802 hasAuthorship W2108485802A5049232814 @default.
• W2108485802 hasAuthorship W2108485802A5054247350 @default.
• W2108485802 hasAuthorship W2108485802A5088941214 @default.
• W2108485802 hasConcept C126322002 @default.
• W2108485802 hasConcept C159654299 @default.
• W2108485802 hasConcept C16685009 @default.
• W2108485802 hasConcept C203014093 @default.
• W2108485802 hasConcept C2778442404 @default.
• W2108485802 hasConcept C2778849806 @default.
• W2108485802 hasConcept C2780091579 @default.
• W2108485802 hasConcept C2780252810 @default.
• W2108485802 hasConcept C2780303639 @default.
• W2108485802 hasConcept C2909675724 @default.
• W2108485802 hasConcept C2911091166 @default.
• W2108485802 hasConcept C71924100 @default.
• W2108485802 hasConcept C86803240 @default.
• W2108485802 hasConceptScore W2108485802C126322002 @default.
• W2108485802 hasConceptScore W2108485802C159654299 @default.
• W2108485802 hasConceptScore W2108485802C16685009 @default.
• W2108485802 hasConceptScore W2108485802C203014093 @default.
• W2108485802 hasConceptScore W2108485802C2778442404 @default.
• W2108485802 hasConceptScore W2108485802C2778849806 @default.
• W2108485802 hasConceptScore W2108485802C2780091579 @default.
• W2108485802 hasConceptScore W2108485802C2780252810 @default.
• W2108485802 hasConceptScore W2108485802C2780303639 @default.
• W2108485802 hasConceptScore W2108485802C2909675724 @default.
• W2108485802 hasConceptScore W2108485802C2911091166 @default.
• W2108485802 hasConceptScore W2108485802C71924100 @default.
• W2108485802 hasConceptScore W2108485802C86803240 @default.
• W2108485802 hasIssue "6" @default.
• W2108485802 hasLocation W21084858021 @default.
• W2108485802 hasLocation W21084858022 @default.
• W2108485802 hasOpenAccess W2108485802 @default.
• W2108485802 hasPrimaryLocation W21084858021 @default.
• W2108485802 hasRelatedWork W1968851954 @default.
• W2108485802 hasRelatedWork W2039925961 @default.

• next