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- W2108490497 abstract "Abstract: TARC/CCL17 (thymus‐ and activation‐regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor‐4 (CCR4) known to be distinctively expressed on Th 2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th 2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA + (cutaneous lymphocyte‐associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th 2 ‐dominated inflammation in the skin. To examine this, we injected BALB/ c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4 + lymphocytes in a dose‐dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin‐4 mRNA but not interferon‐γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th 2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T‐cell‐attracting chemokine ( CTACK/CCL27 ) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th 2 ‐dominated inflammatory reaction when injected into the skin." @default.
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- W2108490497 date "2004-04-01" @default.
- W2108490497 modified "2023-10-11" @default.
- W2108490497 title "Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice" @default.
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- W2108490497 doi "https://doi.org/10.1111/j.0906-6705.2004.00149.x" @default.
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