Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108491377> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2108491377 endingPage "581" @default.
- W2108491377 startingPage "581" @default.
- W2108491377 abstract "Although numerous genetic loci and candidate genes have been identified as contributors to asthma susceptibility and phenotype, the specific “asthma gene [or genes]” located at each susceptibility locus remains largely unknown. In the present study, the investigators aimed to identify the asthma susceptibility gene responsible for genetic linkage to human chromosome 2q14-32. Notably, the IL-1 gene is located in this region, and 2 independent mouse genome searches have linked airway hyperresponsiveness to syntenic regions, highlighting the potential importance of this region. By studying 244 families with atopic asthma (defined by questionnaire results and IgE levels), no association with IL-1 single nucleotide polymorphisms (SNPs) were found, but strong associations with neighboring microsatellite markers were found. Sequencing 462 kb from contiguous artificial chromosomes identified 105 SNPs, establishing a high-density SNP linkage disequilibrium map. Indeed, 1 allele was shown to encode for a polymorphism in the promoter of a known dipeptidyl peptidase (DPP) family member that rendered loss of T-cell nuclear protein binding. Subsequently, the authors cloned this DPP family member, designated DPP10, demonstrating that it encodes for a 3.6-kb cDNA spanning an amazing 1.4 Mb of genomic DNA. DPP10 is encoded for by at least 26 exons and exists in several forms, including soluble and transmembrane species (depending on differential splicing of 5′ exons). Structural analysis predicted that DPP10 removes N-terminal dipeptides from proteins, provided that the penultimate residue is a proline, followed by a serine in the second downstream amino acid position. Searching for cytokines with this motif identified 9 potential DPP substrates, including eotaxin, RANTES, and IL-18. Taken together with the previous identification of another protease (ADAM33) as a human asthma gene, these results suggest a critical role for broad-acting proteases in the development of asthma and allergic disease. As such, novel protease modifiers might someday be useful for asthma therapy. (Allen M et al. Nat Genet 2003;35:258-63.)" @default.
- W2108491377 created "2016-06-24" @default.
- W2108491377 creator A5020094340 @default.
- W2108491377 creator A5056639915 @default.
- W2108491377 date "2004-03-01" @default.
- W2108491377 modified "2023-10-18" @default.
- W2108491377 title "Another protease identified as an asthma master gene" @default.
- W2108491377 doi "https://doi.org/10.1016/j.jaci.2003.12.020" @default.
- W2108491377 hasPublicationYear "2004" @default.
- W2108491377 type Work @default.
- W2108491377 sameAs 2108491377 @default.
- W2108491377 citedByCount "0" @default.
- W2108491377 crossrefType "journal-article" @default.
- W2108491377 hasAuthorship W2108491377A5020094340 @default.
- W2108491377 hasAuthorship W2108491377A5056639915 @default.
- W2108491377 hasConcept C104317684 @default.
- W2108491377 hasConcept C135763542 @default.
- W2108491377 hasConcept C141231307 @default.
- W2108491377 hasConcept C142870003 @default.
- W2108491377 hasConcept C153209595 @default.
- W2108491377 hasConcept C3020804800 @default.
- W2108491377 hasConcept C35605836 @default.
- W2108491377 hasConcept C36823959 @default.
- W2108491377 hasConcept C53702515 @default.
- W2108491377 hasConcept C54355233 @default.
- W2108491377 hasConcept C5911399 @default.
- W2108491377 hasConcept C69991583 @default.
- W2108491377 hasConcept C84597430 @default.
- W2108491377 hasConcept C86803240 @default.
- W2108491377 hasConceptScore W2108491377C104317684 @default.
- W2108491377 hasConceptScore W2108491377C135763542 @default.
- W2108491377 hasConceptScore W2108491377C141231307 @default.
- W2108491377 hasConceptScore W2108491377C142870003 @default.
- W2108491377 hasConceptScore W2108491377C153209595 @default.
- W2108491377 hasConceptScore W2108491377C3020804800 @default.
- W2108491377 hasConceptScore W2108491377C35605836 @default.
- W2108491377 hasConceptScore W2108491377C36823959 @default.
- W2108491377 hasConceptScore W2108491377C53702515 @default.
- W2108491377 hasConceptScore W2108491377C54355233 @default.
- W2108491377 hasConceptScore W2108491377C5911399 @default.
- W2108491377 hasConceptScore W2108491377C69991583 @default.
- W2108491377 hasConceptScore W2108491377C84597430 @default.
- W2108491377 hasConceptScore W2108491377C86803240 @default.
- W2108491377 hasIssue "3" @default.
- W2108491377 hasLocation W21084913771 @default.
- W2108491377 hasOpenAccess W2108491377 @default.
- W2108491377 hasPrimaryLocation W21084913771 @default.
- W2108491377 hasRelatedWork W1985570398 @default.
- W2108491377 hasRelatedWork W2004776908 @default.
- W2108491377 hasRelatedWork W2039171418 @default.
- W2108491377 hasRelatedWork W2073832531 @default.
- W2108491377 hasRelatedWork W2089703083 @default.
- W2108491377 hasRelatedWork W2090859105 @default.
- W2108491377 hasRelatedWork W2126529555 @default.
- W2108491377 hasRelatedWork W2161768497 @default.
- W2108491377 hasRelatedWork W74482306 @default.
- W2108491377 hasRelatedWork W1592611938 @default.
- W2108491377 hasVolume "113" @default.
- W2108491377 isParatext "false" @default.
- W2108491377 isRetracted "false" @default.
- W2108491377 magId "2108491377" @default.
- W2108491377 workType "article" @default.