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- W2108497413 abstract "The protein kinase superfamily is one of the most important families of enzymes in molecular biology. Protein kinases typically catalyze the transfer of the γ-phosphate from ATP to a protein substrate (a highly ubiquitous cellular reaction), thereby controlling key areas of cell regulation. Deregulation of protein kinases is known to contribute to many human diseases, and selective inhibitors of protein kinases are a major area of interest in medicinal chemistry. However, a detailed understanding of many kinase pathways is currently lacking. Before we can effectively design medicinally relevant selective kinase inhibitors, it is necessary to understand the role played by a given kinase in specific signal-transduction cascades and to decipher its protein targets. Here, we describe recent advances towards dissecting protein kinase function through the use of chemical genetics." @default.
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- W2108497413 date "2009-10-01" @default.
- W2108497413 modified "2023-10-05" @default.
- W2108497413 title "Exploring the roles of protein kinases using chemical genetics" @default.
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- W2108497413 doi "https://doi.org/10.4155/fmc.09.50" @default.
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