FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108498093> ?p ?o ?g. }

• W2108498093 endingPage "504" @default.
• W2108498093 startingPage "496" @default.
• W2108498093 abstract "Rheumatoid factors (RFs) are autoantibodies directed against the Fc part of IgG. Considerable evidence exists that there are two classes of RFs, pathological and physiological. Whereas pathological RFs are associated with disease, physiological RFs are considered to be a normal component of the immune response. RF(+) precursor B cells present as part of the B cell repertoire of healthy individuals are held responsible for the production of physiological RFs, which is a transient phenomenon with a clear correlation with an initiating stimulus such as immunization or exposure to an infection. Here we demonstrate a difference in the regulatory control of total Ig and RF production by peripheral blood (PB) B cells of both healthy controls (HC) and patients with rheumatoid arthritis (RA). Highly purified B cells from HC and patients with RA were cocultured with T cells stimulated with immobilized anti-CD3 mAb. Similar to IgM production, IgM-RF production was shown to be dependent on CD40 cross-linking. However, activation of PB B cells in the CD40 system in the presence of IL-2, IL-4, IL-10, combinations of these cytokines or supernatant of anti-CD3-stimulated T cells failed to induce detectable IgM-RF, whereas total IgM production was considerable. From these results we conclude that conditions to activate physiological RF(+) B cells require additional contact besides CD40--CD40L interactions between T and B cells. Since the requirements for RF production were similar using PB B cells from HC and patients with RA it is suggested that the regulatory properties of RF(+) precursors in the PB B cell compartment is equal among these groups. Together, these results indicate that conditions for the induction of total Ig and physiological RFs are different." @default.
• W2108498093 created "2016-06-24" @default.
• W2108498093 creator A5001814779 @default.
• W2108498093 creator A5002498432 @default.
• W2108498093 creator A5026758407 @default.
• W2108498093 creator A5052424289 @default.
• W2108498093 creator A5069641539 @default.
• W2108498093 creator A5083103656 @default.
• W2108498093 date "2001-03-01" @default.
• W2108498093 modified "2023-10-03" @default.
• W2108498093 title "Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cells" @default.
• W2108498093 cites W108974051 @default.
• W2108498093 cites W1501578255 @default.
• W2108498093 cites W1515400577 @default.
• W2108498093 cites W1567730870 @default.
• W2108498093 cites W1568839992 @default.
• W2108498093 cites W1582144994 @default.
• W2108498093 cites W1583246305 @default.
• W2108498093 cites W1583870100 @default.
• W2108498093 cites W1911320305 @default.
• W2108498093 cites W193289982 @default.
• W2108498093 cites W1965159033 @default.
• W2108498093 cites W1971392253 @default.
• W2108498093 cites W1971429636 @default.
• W2108498093 cites W1972023858 @default.
• W2108498093 cites W1975690196 @default.
• W2108498093 cites W1991022207 @default.
• W2108498093 cites W1995354632 @default.
• W2108498093 cites W1996006149 @default.
• W2108498093 cites W2003674897 @default.
• W2108498093 cites W2009658842 @default.
• W2108498093 cites W2032169254 @default.
• W2108498093 cites W2033997488 @default.
• W2108498093 cites W2034389796 @default.
• W2108498093 cites W2035728618 @default.
• W2108498093 cites W2037240183 @default.
• W2108498093 cites W2040083095 @default.
• W2108498093 cites W2044217409 @default.
• W2108498093 cites W2045502143 @default.
• W2108498093 cites W2054686030 @default.
• W2108498093 cites W2056448421 @default.
• W2108498093 cites W2063389584 @default.
• W2108498093 cites W2067416672 @default.
• W2108498093 cites W2072642790 @default.
• W2108498093 cites W2079087240 @default.
• W2108498093 cites W2083026214 @default.
• W2108498093 cites W2086417745 @default.
• W2108498093 cites W2094977476 @default.
• W2108498093 cites W2098430467 @default.
• W2108498093 cites W2124010557 @default.
• W2108498093 cites W2132563232 @default.
• W2108498093 cites W2134753241 @default.
• W2108498093 cites W2142373189 @default.
• W2108498093 cites W2149829681 @default.
• W2108498093 cites W2150258528 @default.
• W2108498093 cites W2150796080 @default.
• W2108498093 cites W2152348310 @default.
• W2108498093 cites W2171451570 @default.
• W2108498093 cites W313848116 @default.
• W2108498093 cites W4313333676 @default.
• W2108498093 cites W2463325440 @default.
• W2108498093 doi "https://doi.org/10.1046/j.1365-2249.2001.01475.x" @default.
• W2108498093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1906001" @default.
• W2108498093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11298139" @default.
• W2108498093 hasPublicationYear "2001" @default.
• W2108498093 type Work @default.
• W2108498093 sameAs 2108498093 @default.
• W2108498093 citedByCount "12" @default.
• W2108498093 countsByYear W21084980932012 @default.
• W2108498093 countsByYear W21084980932014 @default.
• W2108498093 countsByYear W21084980932015 @default.
• W2108498093 countsByYear W21084980932021 @default.
• W2108498093 crossrefType "journal-article" @default.
• W2108498093 hasAuthorship W2108498093A5001814779 @default.
• W2108498093 hasAuthorship W2108498093A5002498432 @default.
• W2108498093 hasAuthorship W2108498093A5026758407 @default.
• W2108498093 hasAuthorship W2108498093A5052424289 @default.
• W2108498093 hasAuthorship W2108498093A5069641539 @default.
• W2108498093 hasAuthorship W2108498093A5083103656 @default.
• W2108498093 hasBestOaLocation W21084980931 @default.
• W2108498093 hasConcept C145558887 @default.
• W2108498093 hasConcept C154317977 @default.
• W2108498093 hasConcept C159654299 @default.
• W2108498093 hasConcept C163764329 @default.
• W2108498093 hasConcept C202751555 @default.
• W2108498093 hasConcept C203014093 @default.
• W2108498093 hasConcept C2776090121 @default.
• W2108498093 hasConcept C2776232647 @default.
• W2108498093 hasConcept C2776553844 @default.
• W2108498093 hasConcept C2778453870 @default.
• W2108498093 hasConcept C2780898057 @default.
• W2108498093 hasConcept C39347974 @default.
• W2108498093 hasConcept C55493867 @default.
• W2108498093 hasConcept C67662055 @default.
• W2108498093 hasConcept C71924100 @default.
• W2108498093 hasConcept C86803240 @default.
• W2108498093 hasConcept C8891405 @default.
• W2108498093 hasConceptScore W2108498093C145558887 @default.

• next