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- W2108498259 abstract "Understanding the mechanisms of augmented bacterial pathogenicity in post-viral infections is the first step in the development of an effective therapy. This study assessed the effect of human coronavirus NL63 (HCoV-NL63) on the adherence of bacterial pathogens associated with respiratory tract illnesses. It was shown that HCoV-NL63 infection resulted in an increased adherence of Streptococcus pneumoniae to virus-infected cell lines and fully differentiated primary human airway epithelium cultures. The enhanced binding of bacteria correlated with an increased expression level of the platelet-activating factor receptor (PAF-R), but detailed evaluation of the bacterium–PAF-R interaction revealed a limited relevance of this process." @default.
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- W2108498259 date "2011-06-01" @default.
- W2108498259 modified "2023-10-14" @default.
- W2108498259 title "Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells" @default.
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- W2108498259 doi "https://doi.org/10.1099/vir.0.028381-0" @default.
- W2108498259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3168281" @default.
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