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• W2108499341 endingPage "1438" @default.
• W2108499341 startingPage "1427" @default.
• W2108499341 abstract "Inherited mutations in the intermediate filament (IF) proteins keratin 5 (K5) or keratin 14 (K14) cause epidermolysis bullosa simplex (EBS), in which basal layer keratinocytes rupture upon trauma to the epidermis. Most mutations are missense alleles affecting amino acids located in the central α-helical rod domain of K5 and K14. Here, we study the properties of an unusual EBS-causing mutation in which a nucleotide deletion (1649delG) alters the last 41 amino acids and adds 35 residues to the C terminus of K5. Relative to wild type, filaments coassembled in vitro from purified K5-1649delG and K14 proteins are shorter and exhibit weak viscoelastic properties when placed under strain. Loss of the C-terminal 41 residues contributes to these alterations. When transfected in cultured epithelial cells, K5-1649delG incorporates into preexisting keratin IFs and also forms multiple small aggregates that often colocalize with hsp70 in the cytoplasm. Aggregation is purely a function of the K5-1649delG tail domain; in contrast, the cloned 109 residue-long tail domain from wild type K5 is distributed throughout the cytoplasm and colocalizes partly with keratin IFs. These data provide a mechanistic basis for the cell fragility seen in individuals bearing the K5-1649delG allele, and point to the role of the C-terminal 41 residues in determining K5's assembly properties." @default.
• W2108499341 created "2016-06-24" @default.
• W2108499341 creator A5040215047 @default.
• W2108499341 creator A5074920093 @default.
• W2108499341 date "2005-03-01" @default.
• W2108499341 modified "2023-10-14" @default.
• W2108499341 title "Defining the Properties of the Nonhelical Tail Domain in Type II Keratin 5: Insight from a Bullous Disease-causing Mutation" @default.
• W2108499341 cites W14421278 @default.
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• W2108499341 cites W1541383992 @default.
• W2108499341 cites W1552753876 @default.
• W2108499341 cites W1602235258 @default.
• W2108499341 cites W1818552086 @default.
• W2108499341 cites W1940477445 @default.
• W2108499341 cites W1964851941 @default.
• W2108499341 cites W1969281285 @default.
• W2108499341 cites W1977869838 @default.
• W2108499341 cites W1981013066 @default.
• W2108499341 cites W1981053131 @default.
• W2108499341 cites W1984077784 @default.
• W2108499341 cites W1984610550 @default.
• W2108499341 cites W1986748798 @default.
• W2108499341 cites W1987740540 @default.
• W2108499341 cites W1992290203 @default.
• W2108499341 cites W1995789984 @default.
• W2108499341 cites W2001394865 @default.
• W2108499341 cites W2003797736 @default.
• W2108499341 cites W2006723235 @default.
• W2108499341 cites W2008038482 @default.
• W2108499341 cites W2010616064 @default.
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• W2108499341 cites W2017134832 @default.
• W2108499341 cites W2017830084 @default.
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• W2108499341 cites W2038106537 @default.
• W2108499341 cites W2049526346 @default.
• W2108499341 cites W2049672237 @default.
• W2108499341 cites W2051804495 @default.
• W2108499341 cites W2054468691 @default.
• W2108499341 cites W2054555466 @default.
• W2108499341 cites W2054861016 @default.
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• W2108499341 cites W2066390328 @default.
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• W2108499341 cites W2167104038 @default.
• W2108499341 cites W2169448433 @default.
• W2108499341 cites W2170400730 @default.
• W2108499341 cites W2175920363 @default.
• W2108499341 cites W2322766746 @default.
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• W2108499341 doi "https://doi.org/10.1091/mbc.e04-06-0498" @default.
• W2108499341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/551504" @default.
• W2108499341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15647384" @default.
• W2108499341 hasPublicationYear "2005" @default.
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