FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108499515> ?p ?o ?g. }

• W2108499515 endingPage "10" @default.
• W2108499515 startingPage "6502" @default.
• W2108499515 abstract "The ability of enterotoxin-based mucosal adjuvants to induce CD8+ MHC class I-restricted CTL responses to a codelivered bystander Ag was examined. Escherichia coli heat-labile toxin (LT), or derivatives of LT carrying mutations in the A subunit (LTR72, LTK63), were tested in parallel with cholera toxin (CT) or a fusion protein consisting of the A1 subunit of CT fused to the Ig binding domain of Staphylococcus aureus protein A (called CTA1-DD). Intranasal (i.n.) immunization of C57BL/6 mice with CT, CTA1-DD, LT, LTR72, LTK63, but not rLT-B, elicited MHC class I-restricted CD8+ T cell responses to coadministered OVA or the OVA CTL peptide SIINFEKL (OVA257-264). CT, LT, and LTR72 also induced CTL responses to OVA after s.c. or oral coimmunization whereas LTK63 only activated responses after s.c. coimmunization. rLT-B was unable to adjuvant CTL responses to OVA or OVA257-264 administered by any route. Mice treated with an anti-CD4 mAb to deplete CD4+ T cells mounted significant OVA-specific CTL responses after i.n. coadministration of LT with OVA or OVA257-264. Both 51Cr release assays and IFN-gamma enzyme-linked immunospot assays indicated that IFN-gamma-/- and IL-12 p40-/- gene knockout mice developed CTL responses equivalent to those detected in normal C57BL/6 mice. The results highlight the versatility of toxin-based adjuvants and suggest that LT potentiates CTL responses independently of IL-12 and IFN-gamma and probably by a mechanism unrelated to cross-priming." @default.
• W2108499515 created "2016-06-24" @default.
• W2108499515 creator A5006985309 @default.
• W2108499515 creator A5023995190 @default.
• W2108499515 creator A5025794428 @default.
• W2108499515 creator A5032122956 @default.
• W2108499515 creator A5039475324 @default.
• W2108499515 creator A5073865405 @default.
• W2108499515 creator A5086124703 @default.
• W2108499515 creator A5091062006 @default.
• W2108499515 date "1999-12-15" @default.
• W2108499515 modified "2023-09-23" @default.
• W2108499515 title "MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants." @default.
• W2108499515 cites W1484758027 @default.
• W2108499515 cites W1501518736 @default.
• W2108499515 cites W1529615732 @default.
• W2108499515 cites W1578274427 @default.
• W2108499515 cites W1637232318 @default.
• W2108499515 cites W1660413876 @default.
• W2108499515 cites W1669165205 @default.
• W2108499515 cites W1678167583 @default.
• W2108499515 cites W1760886018 @default.
• W2108499515 cites W1792672594 @default.
• W2108499515 cites W1827631437 @default.
• W2108499515 cites W1924533991 @default.
• W2108499515 cites W1967581597 @default.
• W2108499515 cites W1972863218 @default.
• W2108499515 cites W1976713659 @default.
• W2108499515 cites W1977331253 @default.
• W2108499515 cites W1980624354 @default.
• W2108499515 cites W1980692933 @default.
• W2108499515 cites W1997740378 @default.
• W2108499515 cites W2008046589 @default.
• W2108499515 cites W2016266703 @default.
• W2108499515 cites W2018630189 @default.
• W2108499515 cites W2035620466 @default.
• W2108499515 cites W2047242028 @default.
• W2108499515 cites W2048885114 @default.
• W2108499515 cites W2051486649 @default.
• W2108499515 cites W2056178732 @default.
• W2108499515 cites W2063053561 @default.
• W2108499515 cites W2074061180 @default.
• W2108499515 cites W2079254793 @default.
• W2108499515 cites W2079504227 @default.
• W2108499515 cites W2084146385 @default.
• W2108499515 cites W2088645772 @default.
• W2108499515 cites W2089262366 @default.
• W2108499515 cites W2091570574 @default.
• W2108499515 cites W2112990035 @default.
• W2108499515 cites W2119542365 @default.
• W2108499515 cites W2119553086 @default.
• W2108499515 cites W2122511642 @default.
• W2108499515 cites W2124254865 @default.
• W2108499515 cites W2124936923 @default.
• W2108499515 cites W2127742089 @default.
• W2108499515 cites W2128091590 @default.
• W2108499515 cites W2129327657 @default.
• W2108499515 cites W2131246210 @default.
• W2108499515 cites W2137635909 @default.
• W2108499515 cites W2145200173 @default.
• W2108499515 cites W2154921493 @default.
• W2108499515 cites W2158401973 @default.
• W2108499515 cites W2171387123 @default.
• W2108499515 cites W2171986697 @default.
• W2108499515 cites W2419171285 @default.
• W2108499515 cites W2921429292 @default.
• W2108499515 cites W34640704 @default.
• W2108499515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10586042" @default.
• W2108499515 hasPublicationYear "1999" @default.
• W2108499515 type Work @default.
• W2108499515 sameAs 2108499515 @default.
• W2108499515 citedByCount "28" @default.
• W2108499515 countsByYear W21084995152012 @default.
• W2108499515 countsByYear W21084995152013 @default.
• W2108499515 countsByYear W21084995152014 @default.
• W2108499515 countsByYear W21084995152017 @default.
• W2108499515 countsByYear W21084995152021 @default.
• W2108499515 crossrefType "journal-article" @default.
• W2108499515 hasAuthorship W2108499515A5006985309 @default.
• W2108499515 hasAuthorship W2108499515A5023995190 @default.
• W2108499515 hasAuthorship W2108499515A5025794428 @default.
• W2108499515 hasAuthorship W2108499515A5032122956 @default.
• W2108499515 hasAuthorship W2108499515A5039475324 @default.
• W2108499515 hasAuthorship W2108499515A5073865405 @default.
• W2108499515 hasAuthorship W2108499515A5086124703 @default.
• W2108499515 hasAuthorship W2108499515A5091062006 @default.
• W2108499515 hasConcept C100701293 @default.
• W2108499515 hasConcept C104317684 @default.
• W2108499515 hasConcept C147969180 @default.
• W2108499515 hasConcept C153911025 @default.
• W2108499515 hasConcept C154317977 @default.
• W2108499515 hasConcept C167672396 @default.
• W2108499515 hasConcept C170627219 @default.
• W2108499515 hasConcept C202751555 @default.
• W2108499515 hasConcept C203014093 @default.
• W2108499515 hasConcept C2777006276 @default.
• W2108499515 hasConcept C2777863537 @default.
• W2108499515 hasConcept C2778353597 @default.

• next