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• W2108506598 abstract "We herein report the discovery of a novel class of antagonists of the human adenosine A2B receptor. This low molecular weight scaffold has been optimized to offer derivatives with potential utility for the alleviation of conditions associated with this receptor subtype, such as nociception, diabetes, asthma and COPD. Furthermore, preliminary pharmacokinetic analysis has revealed compounds with profiles suitable for either inhaled or systemic routes of administration." @default.
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• W2108506598 date "2009-10-01" @default.
• W2108506598 modified "2023-10-16" @default.
• W2108506598 title "Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor" @default.
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• W2108506598 doi "https://doi.org/10.1016/j.bmcl.2009.08.040" @default.
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