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- W2108520616 endingPage "217" @default.
- W2108520616 startingPage "195" @default.
- W2108520616 abstract "The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the formation of different homo- and heterodimers. Receptor dimerization promotes activation of the intrinsic kinase, leading to phosphorylation of specific tyrosines located in the ErbB's cytoplasmic region. These phosphorylated residues serve as docking sites for a variety of signaling molecules whose recruitment stimulates intracellular signaling cascades, which ultimately control diverse genetic programs. Particular ligand-receptor complexes have essential roles in embryonic development as well as in the adult. Finally, ErbB receptors are being pursued as therapeutic targets because aberrant ErbB activity has been observed in many human cancers. In this review, we discuss these data in more detail, illustrating the importance of tightly regulated ErbB signaling throughout life." @default.
- W2108520616 created "2016-06-24" @default.
- W2108520616 creator A5023604575 @default.
- W2108520616 creator A5039533464 @default.
- W2108520616 date "2004-02-10" @default.
- W2108520616 modified "2023-10-10" @default.
- W2108520616 title "ErbB Receptors: Directing Key Signaling Networks Throughout Life" @default.
- W2108520616 cites W1520349149 @default.
- W2108520616 cites W1578432462 @default.
- W2108520616 cites W1579739997 @default.
- W2108520616 cites W1665419471 @default.
- W2108520616 cites W1849285658 @default.
- W2108520616 cites W1870193477 @default.
- W2108520616 cites W1964321121 @default.
- W2108520616 cites W1965300615 @default.
- W2108520616 cites W1966658428 @default.
- W2108520616 cites W1980141913 @default.
- W2108520616 cites W1980268730 @default.
- W2108520616 cites W1982210988 @default.
- W2108520616 cites W1983530651 @default.
- W2108520616 cites W1994633980 @default.
- W2108520616 cites W2000630926 @default.
- W2108520616 cites W2001215449 @default.
- W2108520616 cites W2004759810 @default.
- W2108520616 cites W2004996319 @default.
- W2108520616 cites W2005204942 @default.
- W2108520616 cites W2008655516 @default.
- W2108520616 cites W2010660480 @default.
- W2108520616 cites W2011642803 @default.
- W2108520616 cites W2012289375 @default.
- W2108520616 cites W2012375478 @default.
- W2108520616 cites W2012629036 @default.
- W2108520616 cites W2014053430 @default.
- W2108520616 cites W2014111401 @default.
- W2108520616 cites W2014457594 @default.
- W2108520616 cites W2016010426 @default.
- W2108520616 cites W2016125507 @default.
- W2108520616 cites W2016568386 @default.
- W2108520616 cites W2022847745 @default.
- W2108520616 cites W2023417672 @default.
- W2108520616 cites W2024651005 @default.
- W2108520616 cites W2025054819 @default.
- W2108520616 cites W2025357617 @default.
- W2108520616 cites W2026863172 @default.
- W2108520616 cites W2027514622 @default.
- W2108520616 cites W2029849554 @default.
- W2108520616 cites W2032989528 @default.
- W2108520616 cites W2033764434 @default.
- W2108520616 cites W2036363901 @default.
- W2108520616 cites W2036550297 @default.
- W2108520616 cites W2038882649 @default.
- W2108520616 cites W2040142253 @default.
- W2108520616 cites W2042193781 @default.
- W2108520616 cites W2043911313 @default.
- W2108520616 cites W2047587366 @default.
- W2108520616 cites W2047797038 @default.
- W2108520616 cites W2049463639 @default.
- W2108520616 cites W2050674912 @default.
- W2108520616 cites W2051120695 @default.
- W2108520616 cites W2051751481 @default.
- W2108520616 cites W2052512448 @default.
- W2108520616 cites W2053535808 @default.
- W2108520616 cites W2055903396 @default.
- W2108520616 cites W2057097544 @default.
- W2108520616 cites W2057458801 @default.
- W2108520616 cites W2058620780 @default.
- W2108520616 cites W2059041221 @default.
- W2108520616 cites W2062542077 @default.
- W2108520616 cites W2064047613 @default.
- W2108520616 cites W2067374132 @default.
- W2108520616 cites W2067376187 @default.
- W2108520616 cites W2069526613 @default.
- W2108520616 cites W2072029167 @default.
- W2108520616 cites W2072218566 @default.
- W2108520616 cites W2074568047 @default.
- W2108520616 cites W2075059021 @default.
- W2108520616 cites W2076718022 @default.
- W2108520616 cites W2077374035 @default.
- W2108520616 cites W2079574908 @default.
- W2108520616 cites W2083456571 @default.
- W2108520616 cites W2086020303 @default.
- W2108520616 cites W2086921078 @default.
- W2108520616 cites W2087065964 @default.
- W2108520616 cites W2092897704 @default.
- W2108520616 cites W2095156669 @default.
- W2108520616 cites W2099583536 @default.
- W2108520616 cites W2101849511 @default.
- W2108520616 cites W2101862196 @default.
- W2108520616 cites W2102718676 @default.
- W2108520616 cites W2104963800 @default.
- W2108520616 cites W2105516763 @default.
- W2108520616 cites W2111941775 @default.
- W2108520616 cites W2112522176 @default.
- W2108520616 cites W2114291028 @default.
- W2108520616 cites W2114536437 @default.
- W2108520616 cites W2116323570 @default.
- W2108520616 cites W2121170253 @default.
- W2108520616 cites W2123206362 @default.