FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108522791> ?p ?o ?g. }

• W2108522791 endingPage "4214" @default.
• W2108522791 startingPage "4205" @default.
• W2108522791 abstract "ABSTRACT The vaccinia virus (VACV) complement control protein (VCP) is the major protein secreted from VACV-infected cells. It has been reported that VCP binds to the surfaces of uninfected cells by interacting with heparan sulfate proteoglycans (HSPGs). In this study, we show that VCP is also expressed on the surfaces of infected cells and demonstrate that surface localization occurs independently of HSPGs. Since VCP does not contain a transmembrane domain, we hypothesized that VCP interacts with a membrane protein that localizes to the infected-cell surface. We show that the VACV A56 membrane protein is necessary for the cell surface expression of VCP and demonstrate that VCP and A56 interact in VACV-infected cells. Since the surface expression of VCP was abrogated by reducing agents, we examined the contribution of an unpaired cysteine residue on VCP to VCP surface expression and VCP's interaction with A56. To do this, we mutated the unpaired cysteine in VCP and generated a recombinant virus expressing the altered form of VCP. Following the infection of cells with the mutant virus, VCP was neither expressed on the cell surface nor able to interact with A56. Importantly, the cell surface expression of VCP was found to protect infected cells from complement-mediated lysis. Our findings suggest a new function for VCP that may be important for poxvirus pathogenesis and impact immune responses to VACV-based vaccines." @default.
• W2108522791 created "2016-06-24" @default.
• W2108522791 creator A5005555110 @default.
• W2108522791 creator A5022156816 @default.
• W2108522791 creator A5037976626 @default.
• W2108522791 creator A5039404252 @default.
• W2108522791 creator A5045074845 @default.
• W2108522791 creator A5065002010 @default.
• W2108522791 date "2008-05-01" @default.
• W2108522791 modified "2023-10-18" @default.
• W2108522791 title "Cell Surface Expression of the Vaccinia Virus Complement Control Protein Is Mediated by Interaction with the Viral A56 Protein and Protects Infected Cells from Complement Attack" @default.
• W2108522791 cites W121687570 @default.
• W2108522791 cites W1508924431 @default.
• W2108522791 cites W1534482403 @default.
• W2108522791 cites W1616543567 @default.
• W2108522791 cites W1794637429 @default.
• W2108522791 cites W1905880865 @default.
• W2108522791 cites W1910602244 @default.
• W2108522791 cites W1938751745 @default.
• W2108522791 cites W1968838522 @default.
• W2108522791 cites W1969078574 @default.
• W2108522791 cites W1979948206 @default.
• W2108522791 cites W1989186015 @default.
• W2108522791 cites W1992918473 @default.
• W2108522791 cites W2003509774 @default.
• W2108522791 cites W2010935970 @default.
• W2108522791 cites W2018958370 @default.
• W2108522791 cites W2028793056 @default.
• W2108522791 cites W2055874010 @default.
• W2108522791 cites W2057894074 @default.
• W2108522791 cites W2058606755 @default.
• W2108522791 cites W2058992020 @default.
• W2108522791 cites W2065648047 @default.
• W2108522791 cites W2079530987 @default.
• W2108522791 cites W2083971069 @default.
• W2108522791 cites W2094031027 @default.
• W2108522791 cites W2097225513 @default.
• W2108522791 cites W2108268266 @default.
• W2108522791 cites W2114697705 @default.
• W2108522791 cites W2118160968 @default.
• W2108522791 cites W2119820756 @default.
• W2108522791 cites W2140872922 @default.
• W2108522791 cites W2141107197 @default.
• W2108522791 cites W2145478479 @default.
• W2108522791 cites W2148235686 @default.
• W2108522791 cites W2153163492 @default.
• W2108522791 cites W2164858718 @default.
• W2108522791 cites W2165022564 @default.
• W2108522791 cites W2167619535 @default.
• W2108522791 cites W2169301387 @default.
• W2108522791 cites W2169643594 @default.
• W2108522791 cites W2170974892 @default.
• W2108522791 cites W2172284061 @default.
• W2108522791 cites W2247920240 @default.
• W2108522791 cites W2323670460 @default.
• W2108522791 cites W315197452 @default.
• W2108522791 doi "https://doi.org/10.1128/jvi.02426-07" @default.
• W2108522791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2293032" @default.
• W2108522791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18287241" @default.
• W2108522791 hasPublicationYear "2008" @default.
• W2108522791 type Work @default.
• W2108522791 sameAs 2108522791 @default.
• W2108522791 citedByCount "40" @default.
• W2108522791 countsByYear W21085227912012 @default.
• W2108522791 countsByYear W21085227912013 @default.
• W2108522791 countsByYear W21085227912014 @default.
• W2108522791 countsByYear W21085227912015 @default.
• W2108522791 countsByYear W21085227912017 @default.
• W2108522791 countsByYear W21085227912018 @default.
• W2108522791 countsByYear W21085227912020 @default.
• W2108522791 countsByYear W21085227912022 @default.
• W2108522791 countsByYear W21085227912023 @default.
• W2108522791 crossrefType "journal-article" @default.
• W2108522791 hasAuthorship W2108522791A5005555110 @default.
• W2108522791 hasAuthorship W2108522791A5022156816 @default.
• W2108522791 hasAuthorship W2108522791A5037976626 @default.
• W2108522791 hasAuthorship W2108522791A5039404252 @default.
• W2108522791 hasAuthorship W2108522791A5045074845 @default.
• W2108522791 hasAuthorship W2108522791A5065002010 @default.
• W2108522791 hasBestOaLocation W21085227911 @default.
• W2108522791 hasConcept C104317684 @default.
• W2108522791 hasConcept C111684460 @default.
• W2108522791 hasConcept C138873322 @default.
• W2108522791 hasConcept C142669718 @default.
• W2108522791 hasConcept C1491633281 @default.
• W2108522791 hasConcept C159047783 @default.
• W2108522791 hasConcept C203014093 @default.
• W2108522791 hasConcept C2522874641 @default.
• W2108522791 hasConcept C2781356689 @default.
• W2108522791 hasConcept C40767141 @default.
• W2108522791 hasConcept C50244902 @default.
• W2108522791 hasConcept C55493867 @default.
• W2108522791 hasConcept C86803240 @default.
• W2108522791 hasConcept C8891405 @default.
• W2108522791 hasConcept C92731135 @default.
• W2108522791 hasConcept C95444343 @default.
• W2108522791 hasConceptScore W2108522791C104317684 @default.
• W2108522791 hasConceptScore W2108522791C111684460 @default.

• next