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• W2108532039 abstract "This review will briefly summarize current knowledge on the basolateral ammonia transport mechanisms in the thick ascending limb (TAL) of the loop of Henle. This segment transports ammonia against a concentration gradient and is responsible for the accumulation of ammonia in the medullary interstitium, which, in turn, favors ammonia secretion across the collecting duct. Experimental data indicate that the sodium/hydrogen ion exchanger isoform 4 (NHE4; Scl9a4) is a sodium/ammonia exchanger and plays a major role in this process. Disruption of murine NHE4 leads to metabolic acidosis with inappropriate urinary ammonia excretion and decreases the ability of the TAL to absorb ammonia and to build the corticopapillary ammonia gradient. However, NHE4 does not account for the entirety of ammonia absorption by the TAL, indicating that, at least, one more transporter is involved." @default.
• W2108532039 created "2016-06-24" @default.
• W2108532039 creator A5030271567 @default.
• W2108532039 creator A5041162548 @default.
• W2108532039 date "2012-02-01" @default.
• W2108532039 modified "2023-10-16" @default.
• W2108532039 title "More actors in ammonia absorption by the thick ascending limb" @default.
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• W2108532039 doi "https://doi.org/10.1152/ajprenal.00307.2011" @default.
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