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• W2108537388 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-proliferative effects and induce apoptosis in colon and other cancers. In the present study, we report that mefenamic acid (MEF), a member of NSAIDs, has an inhibitory effect on a proliferation of liver cancer cells. We used Chang and Huh-7 cells as human liver cancer cells. MEF-treated Huh-7 and Chang cells displayed apoptotic morphological changes and the portion of cells in sub G1 was increased 3-fold and 6-fold, respectively, at a 200 microM concentration. We also show an MEF-enhanced binding of annexin V to cells and an increased activity of caspase-3 to cleave PARP-1 and caspase itself. The inhibitor of caspase-3 blocked PARP-1 cleavage activity and protected against MEF-induced apoptotic cell death. These results indicate that MEF induces apoptosis in human liver cancer cells." @default.
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• W2108537388 date "2004-10-01" @default.
• W2108537388 modified "2023-10-15" @default.
• W2108537388 title "Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway" @default.
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• W2108537388 doi "https://doi.org/10.1016/j.lfs.2004.04.042" @default.
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