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- W2108543933 abstract "Aims: Clozapine treatment of schizophrenia is effective only in 30–60% of individuals. Since genetic factors are believed to play a significant role in the variation of response to antipsychotics, the aim of the present study was to verify the effect of a G-protein gene polymorphism on clozapine response and clozapine-induced generalized seizures in Brazilian patients with schizophrenia. Patients & methods: In total, 121 schizophrenic patients in treatment with clozapine were genotyped for the 825C>T polymorphism it the GNB3 gene using PCR. Results: Homozygosity for the T825 allele was more frequent among nonresponders (χ 2 = 7.708; p = 0.021), and carriers of this allele had a higher risk to present a convulsion episode (χ 2 = 7.279; p = 0.007). These results were confirmed after controlling for covariates by logistic regression. Conclusion: Our data suggest an influence of the 825C>T polymorphism on clozapine response in persons with schizophrenia and also on a specific neurological side effect (generalized seizures) under clozapine treatment." @default.
- W2108543933 created "2016-06-24" @default.
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- W2108543933 date "2008-10-01" @default.
- W2108543933 modified "2023-10-18" @default.
- W2108543933 title "G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics" @default.
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- W2108543933 doi "https://doi.org/10.2217/14622416.9.10.1429" @default.
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