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- W2108545229 abstract "Retinal implants are intended to help patients with degenerative conditions by electrically stimulating surviving cells to produce artificial vision. However, little is known about how individual retinal ganglion cells respond to direct electrical stimulation in degenerating retina. Here we used a transgenic rat model to characterize ganglion cell responses to light and electrical stimulation during photoreceptor degeneration. Retinas from pigmented P23H-1 rats were compared with wild-type retinas between ages P37 and P752. During degeneration, retinal thickness declined by 50%, largely as a consequence of photoreceptor loss. Spontaneous electrical activity in retinal ganglion cells initially increased two- to threefold, but returned to nearly normal levels around P600. A profound decrease in the number of light-responsive ganglion cells was observed during degeneration, culminating in retinas without detectable light responses by P550. Ganglion cells from transgenic and wild-type animals were targeted for focal electrical stimulation using multielectrode arrays with electrode diameters of ∼10 microns. Ganglion cells were stimulated directly and the success rate of stimulation in both groups was 60–70% at all ages. Surprisingly, thresholds (∼0.05 mC/cm 2 ) and latencies (∼0.25 ms) in P23H rat ganglion cells were comparable to those in wild-type ganglion cells at all ages and showed no change over time. Thus ganglion cells in P23H rats respond normally to direct electrical stimulation despite severe photoreceptor degeneration and complete loss of light responses. These findings suggest that high-resolution epiretinal prosthetic devices may be effective in treating vision loss resulting from photoreceptor degeneration." @default.
- W2108545229 created "2016-06-24" @default.
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- W2108545229 date "2009-12-01" @default.
- W2108545229 modified "2023-10-15" @default.
- W2108545229 title "Loss of Responses to Visual But Not Electrical Stimulation in Ganglion Cells of Rats With Severe Photoreceptor Degeneration" @default.
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- W2108545229 cites W1979353221 @default.
- W2108545229 cites W1979532712 @default.
- W2108545229 cites W1982675266 @default.
- W2108545229 cites W1989440019 @default.
- W2108545229 cites W1990976830 @default.
- W2108545229 cites W1991339030 @default.
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- W2108545229 cites W2010402950 @default.
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- W2108545229 doi "https://doi.org/10.1152/jn.00663.2009" @default.
- W2108545229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2804428" @default.
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