Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108555389> ?p ?o ?g. }
- W2108555389 endingPage "202" @default.
- W2108555389 startingPage "189" @default.
- W2108555389 abstract "Blood neutrophils use CD62L and CD18 adhesion molecules to contact and migrate rapidly through blood vessels in defense against infections in underlying tissues. Previous work showed that glucocorticoid hormones repress expression of CD62L and CD18, causing neutrophilia and increased mastitis susceptibility in dairy cows. The aim of this study was to determine whether bovine neutrophil sensitivity to glucocorticoids exhibits genetic variability. Test animals included 60 pedigreed Holstein bulls treated on 3 consecutive days with a synthetic glucocorticoid (dexamethasone) and five untreated control bulls. Five indicator traits of neutrophil glucocorticoid sensitivity were monitored, including circulating neutrophil counts and two measures on each of CD62L and CD18 expression. Random regression models with treatment-specific serial correlation were used to estimate genetic and non-genetic sources of variation before, during and after glucocorticoid administration. Significant genetic variation was observed for neutrophil CD18 expression, with longitudinal heritability estimates ranging from 0.10 to 0.54 and influenced by dexamethasone. Significant genetic variation was also observed for blood neutrophil counts (heritability estimates ranging from 0.11 to 0.24) but was not influenced by dexamethasone administration. Estimated genetic correlations between circulating neutrophil counts and various indicators of CD62L and CD18 expression were large and negative (-0.44 to - 0.78). These results imply significant genetic variability and pleiotropic effects for neutrophil traits that are important for stress-induced disease susceptibility in dairy cattle and might be exploited by genetic selection." @default.
- W2108555389 created "2016-06-24" @default.
- W2108555389 creator A5000499051 @default.
- W2108555389 creator A5020860584 @default.
- W2108555389 creator A5023418409 @default.
- W2108555389 creator A5045318672 @default.
- W2108555389 creator A5053576640 @default.
- W2108555389 creator A5054265873 @default.
- W2108555389 creator A5057060319 @default.
- W2108555389 date "2002-01-01" @default.
- W2108555389 modified "2023-10-15" @default.
- W2108555389 title "Genetic Variation in Bovine Neutrophil Sensitivity to Glucocorticoid Challenge" @default.
- W2108555389 cites W1551592047 @default.
- W2108555389 cites W15642971 @default.
- W2108555389 cites W1900762885 @default.
- W2108555389 cites W1901628360 @default.
- W2108555389 cites W1965351531 @default.
- W2108555389 cites W1968876320 @default.
- W2108555389 cites W1973277101 @default.
- W2108555389 cites W1984295835 @default.
- W2108555389 cites W1984513526 @default.
- W2108555389 cites W1989683612 @default.
- W2108555389 cites W1993849755 @default.
- W2108555389 cites W1994656151 @default.
- W2108555389 cites W2005668937 @default.
- W2108555389 cites W2020889315 @default.
- W2108555389 cites W2021736035 @default.
- W2108555389 cites W202229671 @default.
- W2108555389 cites W2031551693 @default.
- W2108555389 cites W2034809048 @default.
- W2108555389 cites W2040745169 @default.
- W2108555389 cites W2042111896 @default.
- W2108555389 cites W2049884319 @default.
- W2108555389 cites W2057074090 @default.
- W2108555389 cites W2058080300 @default.
- W2108555389 cites W2063605818 @default.
- W2108555389 cites W2071463859 @default.
- W2108555389 cites W2072737535 @default.
- W2108555389 cites W2084923510 @default.
- W2108555389 cites W2086632308 @default.
- W2108555389 cites W2096386423 @default.
- W2108555389 cites W2101726504 @default.
- W2108555389 cites W2102441384 @default.
- W2108555389 cites W2107971889 @default.
- W2108555389 cites W2127332758 @default.
- W2108555389 cites W2131649050 @default.
- W2108555389 cites W2132925738 @default.
- W2108555389 cites W2141227132 @default.
- W2108555389 cites W2141924291 @default.
- W2108555389 cites W2142637173 @default.
- W2108555389 cites W2152505433 @default.
- W2108555389 cites W2163632526 @default.
- W2108555389 cites W2168175751 @default.
- W2108555389 cites W2409467616 @default.
- W2108555389 cites W4230693812 @default.
- W2108555389 doi "https://doi.org/10.1080/090647002762381078" @default.
- W2108555389 hasPublicationYear "2002" @default.
- W2108555389 type Work @default.
- W2108555389 sameAs 2108555389 @default.
- W2108555389 citedByCount "5" @default.
- W2108555389 crossrefType "journal-article" @default.
- W2108555389 hasAuthorship W2108555389A5000499051 @default.
- W2108555389 hasAuthorship W2108555389A5020860584 @default.
- W2108555389 hasAuthorship W2108555389A5023418409 @default.
- W2108555389 hasAuthorship W2108555389A5045318672 @default.
- W2108555389 hasAuthorship W2108555389A5053576640 @default.
- W2108555389 hasAuthorship W2108555389A5054265873 @default.
- W2108555389 hasAuthorship W2108555389A5057060319 @default.
- W2108555389 hasConcept C104317684 @default.
- W2108555389 hasConcept C126322002 @default.
- W2108555389 hasConcept C134018914 @default.
- W2108555389 hasConcept C135763542 @default.
- W2108555389 hasConcept C161890455 @default.
- W2108555389 hasConcept C171779818 @default.
- W2108555389 hasConcept C172777353 @default.
- W2108555389 hasConcept C203014093 @default.
- W2108555389 hasConcept C2776694085 @default.
- W2108555389 hasConcept C2777063308 @default.
- W2108555389 hasConcept C2777802486 @default.
- W2108555389 hasConcept C2780401358 @default.
- W2108555389 hasConcept C2780841215 @default.
- W2108555389 hasConcept C53122370 @default.
- W2108555389 hasConcept C54355233 @default.
- W2108555389 hasConcept C553184892 @default.
- W2108555389 hasConcept C68873052 @default.
- W2108555389 hasConcept C70616004 @default.
- W2108555389 hasConcept C71924100 @default.
- W2108555389 hasConcept C74133956 @default.
- W2108555389 hasConcept C86803240 @default.
- W2108555389 hasConceptScore W2108555389C104317684 @default.
- W2108555389 hasConceptScore W2108555389C126322002 @default.
- W2108555389 hasConceptScore W2108555389C134018914 @default.
- W2108555389 hasConceptScore W2108555389C135763542 @default.
- W2108555389 hasConceptScore W2108555389C161890455 @default.
- W2108555389 hasConceptScore W2108555389C171779818 @default.
- W2108555389 hasConceptScore W2108555389C172777353 @default.
- W2108555389 hasConceptScore W2108555389C203014093 @default.
- W2108555389 hasConceptScore W2108555389C2776694085 @default.