FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108562020> ?p ?o ?g. }

• W2108562020 endingPage "315" @default.
• W2108562020 startingPage "309" @default.
• W2108562020 abstract "Peptide specificity of cultured tumor-infiltrating lymphocytes (TIL) was systematically investigated in a group of HLA-A2.1+ metastatic melanoma patients consecutively referred to our department for surgical treatment. Seven samples from 6 patients were studied. All surgical specimens showed evidence of gp 100, MART-1/Melan-A and Tyrosinase gene expression as detectable by reverse PCR (rPCR). Cultured TIL from 2 patients displayed cytotoxic activity against autologous or HLA-matched EBV-transformed cells previously pulsed with MART-1/Melan-A27-35 peptide. In contrast, no CTL activity against gp100(280-288) or tyrosinase1-9 peptides could be observed. TIL were then repeatedly stimulated in vitro with the same peptides. After 6 restimulation courses at weekly intervals, specific recognition of gp100(280-288) and MART-1/Melan-A peptides was detectable in 3 and 5 TIL populations, respectively. In one case Tyrosinase1-9-specific CTL could be demonstrated. Two TIL populations from metastases resected from a melanoma patient at 6 months' distance showed a different peptide specificity pattern, and no specific CTL could be generated from simultaneously sampled peripheral blood mononuclear cells (PBMC). All peptide-specific CTL populations also displayed significant cytotoxic activity against HLA-A2.1 matched melanoma cell lines expressing the antigens under investigation. Our data indicate that CTL specific for MART-Melan-A27-35, gp100(280-288) or Tyrosinase1-9 peptides could be expanded with varying frequency from TIL derived from 4 out of 6 HLA-A2.1+ patients whose tumors expressed the genes encoding these tumor-associated antigens (TAA)." @default.
• W2108562020 created "2016-06-24" @default.
• W2108562020 creator A5010971605 @default.
• W2108562020 creator A5030116320 @default.
• W2108562020 creator A5034479226 @default.
• W2108562020 creator A5034812166 @default.
• W2108562020 creator A5038497681 @default.
• W2108562020 creator A5055055091 @default.
• W2108562020 creator A5070000759 @default.
• W2108562020 creator A5079371055 @default.
• W2108562020 creator A5082077047 @default.
• W2108562020 creator A5088269567 @default.
• W2108562020 date "1995-10-20" @default.
• W2108562020 modified "2023-10-14" @default.
• W2108562020 title "Peptide-specific ctl in tumor-infiltrating lymphocytes from metastatic melanomas expressing mart-1/melan-a, gp100 and tyrosinase genes: A study in an unselected group of hla-a2.1-positive patients" @default.
• W2108562020 cites W1930050284 @default.
• W2108562020 cites W1965517166 @default.
• W2108562020 cites W1977273255 @default.
• W2108562020 cites W1977677882 @default.
• W2108562020 cites W1983205909 @default.
• W2108562020 cites W1983682617 @default.
• W2108562020 cites W1984832220 @default.
• W2108562020 cites W1986046751 @default.
• W2108562020 cites W2002038445 @default.
• W2108562020 cites W2006987944 @default.
• W2108562020 cites W2008494452 @default.
• W2108562020 cites W2013360299 @default.
• W2108562020 cites W2023403690 @default.
• W2108562020 cites W2053376515 @default.
• W2108562020 cites W2129092670 @default.
• W2108562020 cites W2130185552 @default.
• W2108562020 cites W2131761283 @default.
• W2108562020 cites W2146600597 @default.
• W2108562020 cites W4294216491 @default.
• W2108562020 doi "https://doi.org/10.1002/ijc.2910640505" @default.
• W2108562020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7591302" @default.
• W2108562020 hasPublicationYear "1995" @default.
• W2108562020 type Work @default.
• W2108562020 sameAs 2108562020 @default.
• W2108562020 citedByCount "57" @default.
• W2108562020 countsByYear W21085620202013 @default.
• W2108562020 countsByYear W21085620202017 @default.
• W2108562020 countsByYear W21085620202019 @default.
• W2108562020 countsByYear W21085620202023 @default.
• W2108562020 crossrefType "journal-article" @default.
• W2108562020 hasAuthorship W2108562020A5010971605 @default.
• W2108562020 hasAuthorship W2108562020A5030116320 @default.
• W2108562020 hasAuthorship W2108562020A5034479226 @default.
• W2108562020 hasAuthorship W2108562020A5034812166 @default.
• W2108562020 hasAuthorship W2108562020A5038497681 @default.
• W2108562020 hasAuthorship W2108562020A5055055091 @default.
• W2108562020 hasAuthorship W2108562020A5070000759 @default.
• W2108562020 hasAuthorship W2108562020A5079371055 @default.
• W2108562020 hasAuthorship W2108562020A5082077047 @default.
• W2108562020 hasAuthorship W2108562020A5088269567 @default.
• W2108562020 hasConcept C137061746 @default.
• W2108562020 hasConcept C147483822 @default.
• W2108562020 hasConcept C147969180 @default.
• W2108562020 hasConcept C153911025 @default.
• W2108562020 hasConcept C154317977 @default.
• W2108562020 hasConcept C167672396 @default.
• W2108562020 hasConcept C181199279 @default.
• W2108562020 hasConcept C188280979 @default.
• W2108562020 hasConcept C202751555 @default.
• W2108562020 hasConcept C203014093 @default.
• W2108562020 hasConcept C2777658100 @default.
• W2108562020 hasConcept C2778326572 @default.
• W2108562020 hasConcept C502942594 @default.
• W2108562020 hasConcept C55493867 @default.
• W2108562020 hasConcept C71924100 @default.
• W2108562020 hasConcept C86803240 @default.
• W2108562020 hasConcept C87554066 @default.
• W2108562020 hasConceptScore W2108562020C137061746 @default.
• W2108562020 hasConceptScore W2108562020C147483822 @default.
• W2108562020 hasConceptScore W2108562020C147969180 @default.
• W2108562020 hasConceptScore W2108562020C153911025 @default.
• W2108562020 hasConceptScore W2108562020C154317977 @default.
• W2108562020 hasConceptScore W2108562020C167672396 @default.
• W2108562020 hasConceptScore W2108562020C181199279 @default.
• W2108562020 hasConceptScore W2108562020C188280979 @default.
• W2108562020 hasConceptScore W2108562020C202751555 @default.
• W2108562020 hasConceptScore W2108562020C203014093 @default.
• W2108562020 hasConceptScore W2108562020C2777658100 @default.
• W2108562020 hasConceptScore W2108562020C2778326572 @default.
• W2108562020 hasConceptScore W2108562020C502942594 @default.
• W2108562020 hasConceptScore W2108562020C55493867 @default.
• W2108562020 hasConceptScore W2108562020C71924100 @default.
• W2108562020 hasConceptScore W2108562020C86803240 @default.
• W2108562020 hasConceptScore W2108562020C87554066 @default.
• W2108562020 hasIssue "5" @default.
• W2108562020 hasLocation W21085620201 @default.
• W2108562020 hasLocation W21085620202 @default.
• W2108562020 hasOpenAccess W2108562020 @default.
• W2108562020 hasPrimaryLocation W21085620201 @default.
• W2108562020 hasRelatedWork W1513096311 @default.
• W2108562020 hasRelatedWork W1965116372 @default.
• W2108562020 hasRelatedWork W1998419826 @default.
• W2108562020 hasRelatedWork W2015747966 @default.

• next