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- W2108562243 abstract "We recently reported isolation of viable rat amniotic fluid-derived stem (AFS) cells [1]. Here, we tested the therapeutic benefits of AFS cells in a rodent model of ischemic stroke. Adult male Sprague-Dawley rats received a 60-minute middle cerebral artery occlusion (MCAo). Thirty-five days later, animals exhibiting significant motor deficits received intravenous transplants of rat AFS cells or vehicle. At days 60-63 post-MCAo, significant recovery of motor and cognitive function was seen in stroke animals transplanted with AFS cells compared to vehicle-infused stroke animals. Infarct volume, as revealed by hematoxylin and eosin (H&E) staining, was significantly reduced, coupled with significant increments in the cell proliferation marker, Ki67, and the neuronal marker, MAP2, in the dentate gyrus (DG) [2] and the subventricular zone (SVZ) of AFS cell-transplanted stroke animals compared to vehicle-infused stroke animals. A significantly higher number of double-labeled Ki67/MAP2-positive cells and a similar trend towards increased Ki67/MAP2 double-labeling were observed in the DG and SVZ of AFS cell-transplanted stroke animals, respectively, compared to vehicle-infused stroke animals. This study reports the therapeutic potential of AFS cell transplantation in stroke animals, possibly via enhancement of endogenous repair mechanisms." @default.
- W2108562243 created "2016-06-24" @default.
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- W2108562243 date "2012-08-17" @default.
- W2108562243 modified "2023-09-26" @default.
- W2108562243 title "Intravenous Grafts Of Amniotic Fluid-Derived Stem Cells Induce Endogenous Cell Proliferation and Attenuate Behavioral Deficits in Ischemic Stroke Rats" @default.
- W2108562243 cites W134744093 @default.
- W2108562243 cites W1556943172 @default.
- W2108562243 cites W1915763889 @default.
- W2108562243 cites W1963599779 @default.
- W2108562243 cites W1965596112 @default.
- W2108562243 cites W1965814140 @default.
- W2108562243 cites W1969574672 @default.
- W2108562243 cites W1973220349 @default.
- W2108562243 cites W1973513613 @default.
- W2108562243 cites W1973910803 @default.
- W2108562243 cites W1987907335 @default.
- W2108562243 cites W1991238683 @default.
- W2108562243 cites W1993091694 @default.
- W2108562243 cites W1994580609 @default.
- W2108562243 cites W1999096596 @default.
- W2108562243 cites W1999901398 @default.
- W2108562243 cites W2001189179 @default.
- W2108562243 cites W2004407958 @default.
- W2108562243 cites W2006897962 @default.
- W2108562243 cites W2010053974 @default.
- W2108562243 cites W2011580597 @default.
- W2108562243 cites W2013657229 @default.
- W2108562243 cites W2014599831 @default.
- W2108562243 cites W2015420584 @default.
- W2108562243 cites W2015663762 @default.
- W2108562243 cites W2016165075 @default.
- W2108562243 cites W2018643417 @default.
- W2108562243 cites W2023656078 @default.
- W2108562243 cites W2024431976 @default.
- W2108562243 cites W2025604203 @default.
- W2108562243 cites W2026251451 @default.
- W2108562243 cites W2031809301 @default.
- W2108562243 cites W2038813826 @default.
- W2108562243 cites W2040336863 @default.
- W2108562243 cites W2041703442 @default.
- W2108562243 cites W2042369174 @default.
- W2108562243 cites W2043206878 @default.
- W2108562243 cites W2043653131 @default.
- W2108562243 cites W2045709574 @default.
- W2108562243 cites W2047180008 @default.
- W2108562243 cites W2049494700 @default.
- W2108562243 cites W2049511526 @default.
- W2108562243 cites W2051007514 @default.
- W2108562243 cites W2068931195 @default.
- W2108562243 cites W2069334904 @default.
- W2108562243 cites W2076137498 @default.
- W2108562243 cites W2078377297 @default.
- W2108562243 cites W2081519346 @default.
- W2108562243 cites W2084106740 @default.
- W2108562243 cites W2084765806 @default.
- W2108562243 cites W2088223614 @default.
- W2108562243 cites W2093050891 @default.
- W2108562243 cites W2093721209 @default.
- W2108562243 cites W2106074932 @default.
- W2108562243 cites W2108461283 @default.
- W2108562243 cites W2124920265 @default.
- W2108562243 cites W2127738960 @default.
- W2108562243 cites W2128616793 @default.
- W2108562243 cites W2130007083 @default.
- W2108562243 cites W2132563862 @default.
- W2108562243 cites W2134845552 @default.
- W2108562243 cites W2135640338 @default.
- W2108562243 cites W2141991716 @default.
- W2108562243 cites W2145356761 @default.
- W2108562243 cites W2147644905 @default.
- W2108562243 cites W2150384215 @default.
- W2108562243 cites W2152035302 @default.
- W2108562243 cites W2152451347 @default.
- W2108562243 cites W2158520768 @default.
- W2108562243 cites W2163806130 @default.
- W2108562243 cites W2163815564 @default.
- W2108562243 cites W2165438231 @default.
- W2108562243 cites W2170014340 @default.
- W2108562243 cites W2281688494 @default.
- W2108562243 cites W2287061889 @default.
- W2108562243 cites W2403657307 @default.
- W2108562243 cites W2410446460 @default.
- W2108562243 cites W90671291 @default.
- W2108562243 doi "https://doi.org/10.1371/journal.pone.0043779" @default.
- W2108562243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3422299" @default.
- W2108562243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22912905" @default.