FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108565584> ?p ?o ?g. }

• W2108565584 endingPage "e13768" @default.
• W2108565584 startingPage "e13768" @default.
• W2108565584 abstract "The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped circulating in the human population in 1968. Strains of H2 subtype still continue to circulate in birds and occasionally pigs and could be reintroduced into the human population through antigenic drift or shift. Such an event is a potential global health concern because of the waning population immunity to H2 hemagglutinin (HA). The first step in such a cross-species transmission and human adaptation of influenza A virus is the ability for its surface glycoprotein HA to bind to glycan receptors expressed in the human upper respiratory epithelia. Recent structural and biochemical studies have focused on understanding the glycan receptor binding specificity of the 1957-58 pandemic H2N2 HA. However, there has been considerable HA sequence divergence in the recent avian-adapted H2 strains from the pandemic H2N2 strain. Using a combination of structural modeling, quantitative glycan binding and human respiratory tissue binding methods, we systematically identify mutations in the HA from a recent avian-adapted H2N2 strain (A/Chicken/PA/2004) that make its quantitative glycan receptor binding affinity (defined using an apparent binding constant) comparable to that of a prototypic pandemic H2N2 (A/Albany/6/58) HA." @default.
• W2108565584 created "2016-06-24" @default.
• W2108565584 creator A5001410017 @default.
• W2108565584 creator A5005118312 @default.
• W2108565584 creator A5006281323 @default.
• W2108565584 creator A5031498236 @default.
• W2108565584 creator A5034097399 @default.
• W2108565584 creator A5065374721 @default.
• W2108565584 creator A5073720554 @default.
• W2108565584 creator A5083896657 @default.
• W2108565584 creator A5090815686 @default.
• W2108565584 date "2010-10-29" @default.
• W2108565584 modified "2023-10-16" @default.
• W2108565584 title "Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin" @default.
• W2108565584 cites W1946489415 @default.
• W2108565584 cites W1950559056 @default.
• W2108565584 cites W1970601906 @default.
• W2108565584 cites W2010186519 @default.
• W2108565584 cites W2036724275 @default.
• W2108565584 cites W2038550582 @default.
• W2108565584 cites W2042839347 @default.
• W2108565584 cites W2043082573 @default.
• W2108565584 cites W2046378278 @default.
• W2108565584 cites W2049740179 @default.
• W2108565584 cites W2057745517 @default.
• W2108565584 cites W2059782458 @default.
• W2108565584 cites W2067284235 @default.
• W2108565584 cites W2072237100 @default.
• W2108565584 cites W2073630636 @default.
• W2108565584 cites W2081169343 @default.
• W2108565584 cites W2093897949 @default.
• W2108565584 cites W2095847051 @default.
• W2108565584 cites W2098349861 @default.
• W2108565584 cites W2102335249 @default.
• W2108565584 cites W2104148197 @default.
• W2108565584 cites W2109111327 @default.
• W2108565584 cites W2121593344 @default.
• W2108565584 cites W2124574957 @default.
• W2108565584 cites W2151666126 @default.
• W2108565584 cites W2154598471 @default.
• W2108565584 cites W2170731906 @default.
• W2108565584 doi "https://doi.org/10.1371/journal.pone.0013768" @default.
• W2108565584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2966429" @default.
• W2108565584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21060797" @default.
• W2108565584 hasPublicationYear "2010" @default.
• W2108565584 type Work @default.
• W2108565584 sameAs 2108565584 @default.
• W2108565584 citedByCount "36" @default.
• W2108565584 countsByYear W21085655842012 @default.
• W2108565584 countsByYear W21085655842013 @default.
• W2108565584 countsByYear W21085655842014 @default.
• W2108565584 countsByYear W21085655842015 @default.
• W2108565584 countsByYear W21085655842016 @default.
• W2108565584 countsByYear W21085655842017 @default.
• W2108565584 countsByYear W21085655842018 @default.
• W2108565584 countsByYear W21085655842019 @default.
• W2108565584 countsByYear W21085655842021 @default.
• W2108565584 countsByYear W21085655842022 @default.
• W2108565584 countsByYear W21085655842023 @default.
• W2108565584 crossrefType "journal-article" @default.
• W2108565584 hasAuthorship W2108565584A5001410017 @default.
• W2108565584 hasAuthorship W2108565584A5005118312 @default.
• W2108565584 hasAuthorship W2108565584A5006281323 @default.
• W2108565584 hasAuthorship W2108565584A5031498236 @default.
• W2108565584 hasAuthorship W2108565584A5034097399 @default.
• W2108565584 hasAuthorship W2108565584A5065374721 @default.
• W2108565584 hasAuthorship W2108565584A5073720554 @default.
• W2108565584 hasAuthorship W2108565584A5083896657 @default.
• W2108565584 hasAuthorship W2108565584A5090815686 @default.
• W2108565584 hasBestOaLocation W21085655841 @default.
• W2108565584 hasConcept C108625454 @default.
• W2108565584 hasConcept C142724271 @default.
• W2108565584 hasConcept C159047783 @default.
• W2108565584 hasConcept C206212055 @default.
• W2108565584 hasConcept C2522874641 @default.
• W2108565584 hasConcept C2777546802 @default.
• W2108565584 hasConcept C2778692840 @default.
• W2108565584 hasConcept C2779134260 @default.
• W2108565584 hasConcept C2908647359 @default.
• W2108565584 hasConcept C3008058167 @default.
• W2108565584 hasConcept C524204448 @default.
• W2108565584 hasConcept C54355233 @default.
• W2108565584 hasConcept C71924100 @default.
• W2108565584 hasConcept C7842527 @default.
• W2108565584 hasConcept C86803240 @default.
• W2108565584 hasConcept C89623803 @default.
• W2108565584 hasConcept C99454951 @default.
• W2108565584 hasConceptScore W2108565584C108625454 @default.
• W2108565584 hasConceptScore W2108565584C142724271 @default.
• W2108565584 hasConceptScore W2108565584C159047783 @default.
• W2108565584 hasConceptScore W2108565584C206212055 @default.
• W2108565584 hasConceptScore W2108565584C2522874641 @default.
• W2108565584 hasConceptScore W2108565584C2777546802 @default.
• W2108565584 hasConceptScore W2108565584C2778692840 @default.
• W2108565584 hasConceptScore W2108565584C2779134260 @default.
• W2108565584 hasConceptScore W2108565584C2908647359 @default.
• W2108565584 hasConceptScore W2108565584C3008058167 @default.
• W2108565584 hasConceptScore W2108565584C524204448 @default.

• next