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• W2108574369 abstract "Background:Multiple sclerosis (MS) is hypothetically caused by autoreactive Th1 and Th17 cells, whereas Th2 and regulatory T cells may confer protection. The development of Th subpopulations is dependant on the expression of lineage-specific transcription factors. Objective:The aim of this study was to assess the balance of CD4 + T cell populations in relapsing-remitting MS. Methods:Blood mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 was assessed in 33 patients with relapsing-remitting MS and 20 healthy controls. In addition, flow cytometry was performed to assess T lymphocyte numbers. Results:In relapsing-remitting MS, diminished expression of FOXP3 (Treg) was found ( p < 0.05), despite normal numbers of CD4 + CD25 hi Treg. Immunoregulatory EBI3 and Th2-associated GATA3 ([a-z]+) was also decreased in MS ( p < 0.005 and p < 0.05, respectively). Expression of TBX21 (Th1) and RORC (Th17) did not differ between patients and controls. Similar changes were observed when analysing beta-interferon treated ( n = 12) or untreated ( n = 21) patients. Analysis of transcription factor ratios, comparing TBX21/GATA3 and RORC/FOXP3, revealed an increase in the RORC/FOXP3 ratio in patients with relapsing-remitting MS ( p < 0.005). Conclusion:Our findings indicate systemic defects at the mRNA level, involving downregulation of beneficial CD4 + phenotypes. This might play a role in disease development by permitting activation of harmful T cell populations." @default.
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• W2108574369 date "2010-09-16" @default.
• W2108574369 modified "2023-10-02" @default.
• W2108574369 title "Transcriptional characteristics of CD4⁺T cells in multiple sclerosis: Relative lack of suppressive populations in blood" @default.
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• W2108574369 doi "https://doi.org/10.1177/1352458510381256" @default.
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