Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108575903> ?p ?o ?g. }
- W2108575903 endingPage "2060" @default.
- W2108575903 startingPage "2052" @default.
- W2108575903 abstract "ABSTRACT In most species, chromatin remodeling mediates critical biological processes ranging from development to disease states. In fungi within the genus Aspergillus , chromatin remodeling may regulate expression of metabolic gene clusters, but other processes regulated by chromatin structure remain to be elucidated. In many eukaryotic species, methylation of lysine 9 of histone 3 (H3K9) is a hallmark of heterochromatin formation and subsequent gene silencing. The sole H3K9 methyltransferase in Schizosaccharomyces pombe is Clr4. We report that disruption of the Clr4 homolog in the pathogenic mold Aspergillus fumigatus (ClrD), which is involved in both mono- and trimethylation of H3K9, results in several growth abnormalities. Developmental defects in ΔAf clrD include reduction in radial growth, reduction in conidial production, and delayed conidiation after developmental competence mediated by delayed expression of brlA , the master regulator of conidiophore development. Sensitivity of ΔAf clrD to 6-azauracil suggests that ClrD influences transcriptional processing in A. fumigatus . Despite growth abnormalities, macrophage assays suggest ClrD may be dispensable for host interactions." @default.
- W2108575903 created "2016-06-24" @default.
- W2108575903 creator A5020654280 @default.
- W2108575903 creator A5024838376 @default.
- W2108575903 creator A5031263971 @default.
- W2108575903 creator A5089606692 @default.
- W2108575903 date "2008-12-01" @default.
- W2108575903 modified "2023-10-16" @default.
- W2108575903 title "H3K9 Methylation Regulates Growth and Development in <i>Aspergillus fumigatus</i>" @default.
- W2108575903 cites W1528728961 @default.
- W2108575903 cites W1577770943 @default.
- W2108575903 cites W1749230666 @default.
- W2108575903 cites W1804649927 @default.
- W2108575903 cites W1883743331 @default.
- W2108575903 cites W1909891465 @default.
- W2108575903 cites W1970475284 @default.
- W2108575903 cites W1974227348 @default.
- W2108575903 cites W1978197643 @default.
- W2108575903 cites W1990374273 @default.
- W2108575903 cites W1991667131 @default.
- W2108575903 cites W1994590215 @default.
- W2108575903 cites W1999284470 @default.
- W2108575903 cites W2002698073 @default.
- W2108575903 cites W2024202925 @default.
- W2108575903 cites W2031213311 @default.
- W2108575903 cites W2031398937 @default.
- W2108575903 cites W2036970927 @default.
- W2108575903 cites W2041729391 @default.
- W2108575903 cites W2043115441 @default.
- W2108575903 cites W2044313365 @default.
- W2108575903 cites W2046269911 @default.
- W2108575903 cites W2046934643 @default.
- W2108575903 cites W2054942267 @default.
- W2108575903 cites W2076494331 @default.
- W2108575903 cites W2077482246 @default.
- W2108575903 cites W2088035403 @default.
- W2108575903 cites W2092794927 @default.
- W2108575903 cites W2094280432 @default.
- W2108575903 cites W2094415799 @default.
- W2108575903 cites W2096234478 @default.
- W2108575903 cites W2098720642 @default.
- W2108575903 cites W2112535875 @default.
- W2108575903 cites W2116798591 @default.
- W2108575903 cites W2116887390 @default.
- W2108575903 cites W2126158040 @default.
- W2108575903 cites W2126976692 @default.
- W2108575903 cites W2129994851 @default.
- W2108575903 cites W2130005065 @default.
- W2108575903 cites W2140680341 @default.
- W2108575903 cites W2141452262 @default.
- W2108575903 cites W2143658931 @default.
- W2108575903 cites W2148683590 @default.
- W2108575903 cites W2150525179 @default.
- W2108575903 cites W2158714788 @default.
- W2108575903 cites W2162296692 @default.
- W2108575903 cites W2162958692 @default.
- W2108575903 cites W2166647372 @default.
- W2108575903 cites W2168154047 @default.
- W2108575903 cites W2170092320 @default.
- W2108575903 cites W2170728895 @default.
- W2108575903 cites W2181998616 @default.
- W2108575903 cites W2739174192 @default.
- W2108575903 cites W3211005720 @default.
- W2108575903 cites W4233618204 @default.
- W2108575903 cites W4242513091 @default.
- W2108575903 doi "https://doi.org/10.1128/ec.00224-08" @default.
- W2108575903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2593193" @default.
- W2108575903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18849468" @default.
- W2108575903 hasPublicationYear "2008" @default.
- W2108575903 type Work @default.
- W2108575903 sameAs 2108575903 @default.
- W2108575903 citedByCount "68" @default.
- W2108575903 countsByYear W21085759032012 @default.
- W2108575903 countsByYear W21085759032013 @default.
- W2108575903 countsByYear W21085759032014 @default.
- W2108575903 countsByYear W21085759032015 @default.
- W2108575903 countsByYear W21085759032016 @default.
- W2108575903 countsByYear W21085759032017 @default.
- W2108575903 countsByYear W21085759032018 @default.
- W2108575903 countsByYear W21085759032019 @default.
- W2108575903 countsByYear W21085759032020 @default.
- W2108575903 countsByYear W21085759032021 @default.
- W2108575903 countsByYear W21085759032022 @default.
- W2108575903 countsByYear W21085759032023 @default.
- W2108575903 crossrefType "journal-article" @default.
- W2108575903 hasAuthorship W2108575903A5020654280 @default.
- W2108575903 hasAuthorship W2108575903A5024838376 @default.
- W2108575903 hasAuthorship W2108575903A5031263971 @default.
- W2108575903 hasAuthorship W2108575903A5089606692 @default.
- W2108575903 hasBestOaLocation W21085759032 @default.
- W2108575903 hasConcept C104317684 @default.
- W2108575903 hasConcept C143065580 @default.
- W2108575903 hasConcept C150194340 @default.
- W2108575903 hasConcept C150425827 @default.
- W2108575903 hasConcept C165864922 @default.
- W2108575903 hasConcept C167227067 @default.
- W2108575903 hasConcept C190727270 @default.
- W2108575903 hasConcept C22709980 @default.