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• W2108576156 startingPage "1195" @default.
• W2108576156 abstract "To identify genes involved in mechanotransduction, Drosophila larvae were screened for X-linked mutations affecting a behavioral response to touch. Many mutations that caused nondevelopmental defects were recovered, among them multiple alleles of the genes uncoordinated (unc) and uncoordinated-like (uncl). Adult flies mutant in these genes showed reduced viability that was associated with behavioral phenotypes ranging from reduced locomotor activity to total uncoordination. Behavioral analysis of mosaic flies indicated that external sensory bristles are a focus of the unc mutant defect. Extracellular recordings from mutant mechanosensory bristles revealed that mechanoreceptor potentials were absent or reduced in both unc and uncl mutants. A second genetic screen, for unc-like uncoordination, yielded mutations in seven genes on the second chromosome; mutations in five of these genes also reduced or eliminated bristle mechanoreceptor potentials. These mutants provide the basis for a genetic, electrophysiological, and molecular dissection of mechanotransduction." @default.
• W2108576156 created "2016-06-24" @default.
• W2108576156 creator A5020024162 @default.
• W2108576156 creator A5065460316 @default.
• W2108576156 creator A5083481401 @default.
• W2108576156 date "1994-06-01" @default.
• W2108576156 modified "2023-10-02" @default.
• W2108576156 title "Genetic dissection of mechanosensory transduction: Mechanoreception-defective mutations of drosophila" @default.
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• W2108576156 doi "https://doi.org/10.1016/0896-6273(94)90437-5" @default.
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