FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108584267> ?p ?o ?g. }

• W2108584267 abstract "Circulating microRNAs (miRNAs) have been found in many body fluids and represent reliable markers of several physio-pathological disorders, including cancer. In some cases, circulating miRNAs have been evaluated as markers of the efficacy of anticancer treatment but it is not yet clear if miRNAs are actively released by tumor cells or derive from dead tumor cells.We showed that a set of prostate cancer secretory miRNAs (PCS-miRNAs) were spontaneously released in the growth medium by DU-145 prostate cancer cells and that the release was greater after treatment with the cytotoxic drug fludarabine. We also found that the miRNAs were associated with exosomes, implying an active mechanism of miRNA release. It should be noted that in fludarabine treated cells the release of miR-485-3p, as well as its association with exosomes, was reduced suggesting that miR-485-3p was retained by surviving cells. Monitoring the intracellular level of miR-485-3p in these cells, we found that miR-485-3p was stably up regulated for several days after treatment. As a possible mechanism we suggest that fludarabine selected cells that harbor high levels of miR-485-3p, which in turn regulates the transcriptional repressor nuclear factor-Y triggering the transcription of topoisomerase IIα, multidrug resistance gene 1 and cyclin B2 pro-survival genes.Cytotoxic treatment of DU-145 cells enhanced the release of PCS-miRNAs with the exception of miR-485-3p which was retained by surviving cells. We speculate that the retention of miR-485-3p was a side effect of fludarabine treatment in that the high intracellular level of miR-485-3p plays a role in the sensitivity to fludarabine." @default.
• W2108584267 created "2016-06-24" @default.
• W2108584267 creator A5011398087 @default.
• W2108584267 creator A5012168756 @default.
• W2108584267 creator A5046995998 @default.
• W2108584267 creator A5080981294 @default.
• W2108584267 date "2013-06-05" @default.
• W2108584267 modified "2023-10-16" @default.
• W2108584267 title "Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival" @default.
• W2108584267 cites W1521676890 @default.
• W2108584267 cites W1774630295 @default.
• W2108584267 cites W1964453634 @default.
• W2108584267 cites W1973242875 @default.
• W2108584267 cites W1977692564 @default.
• W2108584267 cites W1987409881 @default.
• W2108584267 cites W2003206209 @default.
• W2108584267 cites W2019858243 @default.
• W2108584267 cites W2022667041 @default.
• W2108584267 cites W2027488078 @default.
• W2108584267 cites W2030331235 @default.
• W2108584267 cites W2035844407 @default.
• W2108584267 cites W2055313665 @default.
• W2108584267 cites W2068853352 @default.
• W2108584267 cites W2070307875 @default.
• W2108584267 cites W2071742896 @default.
• W2108584267 cites W2074882915 @default.
• W2108584267 cites W2083225806 @default.
• W2108584267 cites W2094077020 @default.
• W2108584267 cites W2097233439 @default.
• W2108584267 cites W2105632406 @default.
• W2108584267 cites W2108417458 @default.
• W2108584267 cites W2111663113 @default.
• W2108584267 cites W2111778115 @default.
• W2108584267 cites W2115093090 @default.
• W2108584267 cites W2120677007 @default.
• W2108584267 cites W2124165058 @default.
• W2108584267 cites W2124304994 @default.
• W2108584267 cites W2131523986 @default.
• W2108584267 cites W2139966272 @default.
• W2108584267 cites W2149280513 @default.
• W2108584267 cites W2149966907 @default.
• W2108584267 cites W2158330587 @default.
• W2108584267 cites W2163169629 @default.
• W2108584267 cites W2163482204 @default.
• W2108584267 doi "https://doi.org/10.1186/1476-4598-12-52" @default.
• W2108584267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3751825" @default.
• W2108584267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23734815" @default.
• W2108584267 hasPublicationYear "2013" @default.
• W2108584267 type Work @default.
• W2108584267 sameAs 2108584267 @default.
• W2108584267 citedByCount "33" @default.
• W2108584267 countsByYear W21085842672013 @default.
• W2108584267 countsByYear W21085842672014 @default.
• W2108584267 countsByYear W21085842672015 @default.
• W2108584267 countsByYear W21085842672016 @default.
• W2108584267 countsByYear W21085842672017 @default.
• W2108584267 countsByYear W21085842672018 @default.
• W2108584267 countsByYear W21085842672019 @default.
• W2108584267 countsByYear W21085842672020 @default.
• W2108584267 countsByYear W21085842672021 @default.
• W2108584267 countsByYear W21085842672022 @default.
• W2108584267 countsByYear W21085842672023 @default.
• W2108584267 crossrefType "journal-article" @default.
• W2108584267 hasAuthorship W2108584267A5011398087 @default.
• W2108584267 hasAuthorship W2108584267A5012168756 @default.
• W2108584267 hasAuthorship W2108584267A5046995998 @default.
• W2108584267 hasAuthorship W2108584267A5080981294 @default.
• W2108584267 hasBestOaLocation W21085842671 @default.
• W2108584267 hasConcept C104317684 @default.
• W2108584267 hasConcept C121608353 @default.
• W2108584267 hasConcept C145059251 @default.
• W2108584267 hasConcept C203014093 @default.
• W2108584267 hasConcept C20518536 @default.
• W2108584267 hasConcept C2776235491 @default.
• W2108584267 hasConcept C2776694085 @default.
• W2108584267 hasConcept C2776755627 @default.
• W2108584267 hasConcept C2779263901 @default.
• W2108584267 hasConcept C2780192828 @default.
• W2108584267 hasConcept C2909763251 @default.
• W2108584267 hasConcept C502942594 @default.
• W2108584267 hasConcept C54355233 @default.
• W2108584267 hasConcept C86803240 @default.
• W2108584267 hasConcept C96232424 @default.
• W2108584267 hasConceptScore W2108584267C104317684 @default.
• W2108584267 hasConceptScore W2108584267C121608353 @default.
• W2108584267 hasConceptScore W2108584267C145059251 @default.
• W2108584267 hasConceptScore W2108584267C203014093 @default.
• W2108584267 hasConceptScore W2108584267C20518536 @default.
• W2108584267 hasConceptScore W2108584267C2776235491 @default.
• W2108584267 hasConceptScore W2108584267C2776694085 @default.
• W2108584267 hasConceptScore W2108584267C2776755627 @default.
• W2108584267 hasConceptScore W2108584267C2779263901 @default.
• W2108584267 hasConceptScore W2108584267C2780192828 @default.
• W2108584267 hasConceptScore W2108584267C2909763251 @default.
• W2108584267 hasConceptScore W2108584267C502942594 @default.
• W2108584267 hasConceptScore W2108584267C54355233 @default.
• W2108584267 hasConceptScore W2108584267C86803240 @default.
• W2108584267 hasConceptScore W2108584267C96232424 @default.
• W2108584267 hasIssue "1" @default.
• W2108584267 hasLocation W21085842671 @default.

• next