FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108589033> ?p ?o ?g. }

• W2108589033 abstract "To observe the effects of Guanxinkang injection, a compound traditional Chinese herbal medicine, on ATP-sensitive potassium (K(ATP)) channel subunits in ischemic myocardial cells of rats, and to explore the mechanism of Guanxinkang in protecting myocardial ischemic reperfusion injuries.Forty-eight Wistar rats were randomly divided into normal group, untreated group, glibenclamide group, pinacidil group, Guanxinkang group and Guanxinkang plus glibenclamide group. The ventricular myocytes were prepared from hearts of normal rats by enzymatic dissociation method. The ischemic ventricular myocytes underwent perfusion with normal Tyrode solution for 10 min, then stopping perfusion 30 min, and followed by 45 min of reperfusion. The glibenclamide, pinacidil and Guanxinkang were added into ventricular myocytes solution directly. Then the solutions were placed at 4 degrees centigrade. After 24-hour freezing at -80 degrees centigrade, mRNA and protein expressions of KATP subunits Kir6.1, Kir6.2, SUR2A and SUR2B were measured by real-time quantitative polymerase chain reaction and Western blotting respectively.In normal rat myocardial cells, there were SUR2A, Kir6.1, and Kir6.2 protein and gene expressions but no expression of SUR2B protein. In the untreated group, all subunit mRNA and protein expressions of KATP increased to some extent as compared with the normal group. Pinacidil, a potassium channel opener, significantly increased mRNA and protein expressions of KATP subunits, while the blocker glibenclamide had a reverse effect. Meanwhile, Guanxinkang injection significantly increased mRNA and protein expressions of K(ATP) subunits but with no significant difference as compared with pinacidil.Guanxinkang injection can obviously enhance the open of KATP channel and thus play a role in cardiovascular protection." @default.
• W2108589033 created "2016-06-24" @default.
• W2108589033 creator A5008293406 @default.
• W2108589033 creator A5009869157 @default.
• W2108589033 creator A5035239799 @default.
• W2108589033 creator A5042467158 @default.
• W2108589033 creator A5073930548 @default.
• W2108589033 creator A5077153113 @default.
• W2108589033 date "2010-05-15" @default.
• W2108589033 modified "2023-09-24" @default.
• W2108589033 title "Effects of Guanxinkang on expressions of ATP-sensitive potassium channel subunits Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes of rats" @default.
• W2108589033 cites W1723882828 @default.
• W2108589033 cites W1969978734 @default.
• W2108589033 cites W1977017927 @default.
• W2108589033 cites W2021667794 @default.
• W2108589033 cites W2062401160 @default.
• W2108589033 cites W2090052077 @default.
• W2108589033 cites W2098886821 @default.
• W2108589033 cites W2171297304 @default.
• W2108589033 cites W2339154093 @default.
• W2108589033 cites W2369509918 @default.
• W2108589033 cites W2376802390 @default.
• W2108589033 doi "https://doi.org/10.3736/jcim20100510" @default.
• W2108589033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20456845" @default.
• W2108589033 hasPublicationYear "2010" @default.
• W2108589033 type Work @default.
• W2108589033 sameAs 2108589033 @default.
• W2108589033 citedByCount "5" @default.
• W2108589033 countsByYear W21085890332012 @default.
• W2108589033 countsByYear W21085890332014 @default.
• W2108589033 countsByYear W21085890332015 @default.
• W2108589033 countsByYear W21085890332016 @default.
• W2108589033 crossrefType "journal-article" @default.
• W2108589033 hasAuthorship W2108589033A5008293406 @default.
• W2108589033 hasAuthorship W2108589033A5009869157 @default.
• W2108589033 hasAuthorship W2108589033A5035239799 @default.
• W2108589033 hasAuthorship W2108589033A5042467158 @default.
• W2108589033 hasAuthorship W2108589033A5073930548 @default.
• W2108589033 hasAuthorship W2108589033A5077153113 @default.
• W2108589033 hasConcept C104292427 @default.
• W2108589033 hasConcept C104317684 @default.
• W2108589033 hasConcept C105580179 @default.
• W2108589033 hasConcept C126322002 @default.
• W2108589033 hasConcept C134018914 @default.
• W2108589033 hasConcept C146957229 @default.
• W2108589033 hasConcept C185592680 @default.
• W2108589033 hasConcept C207200792 @default.
• W2108589033 hasConcept C2775984225 @default.
• W2108589033 hasConcept C2776309818 @default.
• W2108589033 hasConcept C2777194220 @default.
• W2108589033 hasConcept C2777289354 @default.
• W2108589033 hasConcept C2779768347 @default.
• W2108589033 hasConcept C55493867 @default.
• W2108589033 hasConcept C555293320 @default.
• W2108589033 hasConcept C71924100 @default.
• W2108589033 hasConcept C83743174 @default.
• W2108589033 hasConcept C85265743 @default.
• W2108589033 hasConcept C98274493 @default.
• W2108589033 hasConceptScore W2108589033C104292427 @default.
• W2108589033 hasConceptScore W2108589033C104317684 @default.
• W2108589033 hasConceptScore W2108589033C105580179 @default.
• W2108589033 hasConceptScore W2108589033C126322002 @default.
• W2108589033 hasConceptScore W2108589033C134018914 @default.
• W2108589033 hasConceptScore W2108589033C146957229 @default.
• W2108589033 hasConceptScore W2108589033C185592680 @default.
• W2108589033 hasConceptScore W2108589033C207200792 @default.
• W2108589033 hasConceptScore W2108589033C2775984225 @default.
• W2108589033 hasConceptScore W2108589033C2776309818 @default.
• W2108589033 hasConceptScore W2108589033C2777194220 @default.
• W2108589033 hasConceptScore W2108589033C2777289354 @default.
• W2108589033 hasConceptScore W2108589033C2779768347 @default.
• W2108589033 hasConceptScore W2108589033C55493867 @default.
• W2108589033 hasConceptScore W2108589033C555293320 @default.
• W2108589033 hasConceptScore W2108589033C71924100 @default.
• W2108589033 hasConceptScore W2108589033C83743174 @default.
• W2108589033 hasConceptScore W2108589033C85265743 @default.
• W2108589033 hasConceptScore W2108589033C98274493 @default.
• W2108589033 hasLocation W21085890331 @default.
• W2108589033 hasLocation W21085890332 @default.
• W2108589033 hasOpenAccess W2108589033 @default.
• W2108589033 hasPrimaryLocation W21085890331 @default.
• W2108589033 hasRelatedWork W1569835048 @default.
• W2108589033 hasRelatedWork W1981538539 @default.
• W2108589033 hasRelatedWork W2037314949 @default.
• W2108589033 hasRelatedWork W2043619482 @default.
• W2108589033 hasRelatedWork W2061149068 @default.
• W2108589033 hasRelatedWork W2062560673 @default.
• W2108589033 hasRelatedWork W2079555649 @default.
• W2108589033 hasRelatedWork W2084216748 @default.
• W2108589033 hasRelatedWork W2109961696 @default.
• W2108589033 hasRelatedWork W2117972528 @default.
• W2108589033 hasRelatedWork W2144574632 @default.
• W2108589033 hasRelatedWork W2164272715 @default.
• W2108589033 hasRelatedWork W2387067045 @default.
• W2108589033 hasRelatedWork W2416353759 @default.
• W2108589033 hasRelatedWork W2790292033 @default.
• W2108589033 hasRelatedWork W3024047006 @default.
• W2108589033 hasRelatedWork W3025342659 @default.
• W2108589033 hasRelatedWork W3089231330 @default.
• W2108589033 hasRelatedWork W3129933114 @default.

• next