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• W2108591387 abstract "AbstractHMO1 is a high-mobility group B protein that plays a role in transcription of genes encoding rRNA and ribosomal proteins (RPGs) in Saccharomyces cerevisiae. This study uses genome-wide chromatin immunoprecipitation to study the roles of HMO1, FHL1, and RAP1 in transcription of these genes as well as other RNA polymerase II-transcribed genes in yeast. The results show that HMO1 associates with the 35S rRNA gene in an RNA polymerase I-dependent manner and that RPG promoters (138 in total) can be classified into several distinct groups based on HMO1 abundance at the promoter and the HMO1 dependence of FHL1 and/or RAP1 binding to the promoter. FHL1, a key regulator of RPGs, binds to most of the HMO1-enriched and transcriptionally HMO1-dependent RPG promoters in an HMO1-dependent manner, whereas it binds to HMO1-limited RPG promoters in an HMO1-independent manner, irrespective of whether they are transcribed in an HMO1-dependent manner. Reporter gene assays indicate that these functional properties are determined by the promoter sequence. SUPPLEMENTAL MATERIALSupplemental material for this article may be found at http://mcb.asm.org/.We thank H. Iwasaki and other members of our laboratory for advice and comments on this work. We also thank A. G. Hinnebusch, Y. Nakatani, J. Heitman, and M. Nomura for supplying the yeast strains; M. Funk, F. Uhlmann, Y. Tsukihashi, and S. Takahata for the plasmids; and Y. Katou and T. Itoh for their help in genome- wide ChIP analysis. The TAP plasmid was obtained from CellZome (Heidelberg).This study was supported by grant for the 2006 Strategic Research Project (grant W18013) of Yokohama City University and grants from the Japan Society for the Promotion of Science; the Ministry of Education, Culture, Sports, Science and Technology of Japan; CREST of Japan Science and Technology Corporation; and the Mitsubishi Foundation." @default.
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• W2108591387 date "2007-10-01" @default.
• W2108591387 modified "2023-10-09" @default.
• W2108591387 title "Assembly of Regulatory Factors on rRNA and Ribosomal Protein Genes in <i>Saccharomyces cerevisiae</i>" @default.
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• W2108591387 doi "https://doi.org/10.1128/mcb.00876-07" @default.
• W2108591387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2099245" @default.
• W2108591387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17646381" @default.
• W2108591387 hasPublicationYear "2007" @default.
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