FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108592130> ?p ?o ?g. }

• W2108592130 endingPage "1483" @default.
• W2108592130 startingPage "1473" @default.
• W2108592130 abstract "PURPOSE To determine the feasibility and safety of multiple, closely timed courses of high-dose cyclophosphamide, thiotepa, and carboplatin (CTC) with peripheral-blood progenitor-cell transplantation (PBPCT). PATIENTS AND METHODS Forty-eight patients with advanced cancer were scheduled to undergo either two or three courses of CTC with PBPCT. All PBPCs were harvested before high-dose therapy began. Full-dose CTC courses incorporated cyclophosphamide (6,000 mg/m2), thiotepa (480 mg/m2), and carboplatin (1,600 mg/m2) divided over days -6, -5, -4, and -3. Tiny CTC courses (tCTC) contained 67% of the doses of each of these agents. Second or third courses of CTC or tCTC began on day 28. RESULTS A sufficient number of PBPC could be harvested from all but two patients. Thirty-five first full-dose courses of CTC were given, 28 second courses, and 10 third courses. Second courses could be given on time and at full dose in 80% of the patients, but there was one toxic death from venoocclusive disease (VOD). Only four of 12 patients scheduled to receive three courses of full-dose CTC could be treated at the time and dose planned. There were three toxic deaths: one of VOD, one of sepsis, and one of hemolytic uremic syndrome (HUS). Eight patients were scheduled to receive three courses of tCTC. Eight first, seven second, and six third courses were given. One of the third courses had to be delayed and one had to be reduced in dose. CONCLUSION A sufficient number of PBPCs for two or three transplantations can be harvested from most patients without much difficulty before high-dose therapy. Two full-dose CTC courses or three tCTC courses can be given safely and with acceptable toxicity at 5-week intervals. Organ toxicity rather than bone marrow toxicity has become dose-limiting for alkylating agents." @default.
• W2108592130 created "2016-06-24" @default.
• W2108592130 creator A5007237048 @default.
• W2108592130 creator A5021960841 @default.
• W2108592130 creator A5040015584 @default.
• W2108592130 creator A5063335991 @default.
• W2108592130 creator A5079093184 @default.
• W2108592130 creator A5082601500 @default.
• W2108592130 creator A5090670668 @default.
• W2108592130 creator A5090786009 @default.
• W2108592130 date "1996-05-01" @default.
• W2108592130 modified "2023-10-01" @default.
• W2108592130 title "Feasibility of multiple courses of high-dose cyclophosphamide, thiotepa, and carboplatin for breast cancer or germ cell cancer." @default.
• W2108592130 cites W119852850 @default.
• W2108592130 cites W1530057448 @default.
• W2108592130 cites W1533046017 @default.
• W2108592130 cites W1813712453 @default.
• W2108592130 cites W1863712471 @default.
• W2108592130 cites W1881816600 @default.
• W2108592130 cites W1929549982 @default.
• W2108592130 cites W1959087060 @default.
• W2108592130 cites W1974247223 @default.
• W2108592130 cites W1992036820 @default.
• W2108592130 cites W2026451843 @default.
• W2108592130 cites W2028806556 @default.
• W2108592130 cites W2042181783 @default.
• W2108592130 cites W2108703976 @default.
• W2108592130 cites W2113143479 @default.
• W2108592130 cites W2116996913 @default.
• W2108592130 cites W2257291134 @default.
• W2108592130 cites W2259615536 @default.
• W2108592130 cites W2413853954 @default.
• W2108592130 cites W31750938 @default.
• W2108592130 cites W77072281 @default.
• W2108592130 doi "https://doi.org/10.1200/jco.1996.14.5.1473" @default.
• W2108592130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8622061" @default.
• W2108592130 hasPublicationYear "1996" @default.
• W2108592130 type Work @default.
• W2108592130 sameAs 2108592130 @default.
• W2108592130 citedByCount "93" @default.
• W2108592130 countsByYear W21085921302012 @default.
• W2108592130 countsByYear W21085921302013 @default.
• W2108592130 countsByYear W21085921302014 @default.
• W2108592130 countsByYear W21085921302015 @default.
• W2108592130 countsByYear W21085921302018 @default.
• W2108592130 countsByYear W21085921302020 @default.
• W2108592130 countsByYear W21085921302021 @default.
• W2108592130 crossrefType "journal-article" @default.
• W2108592130 hasAuthorship W2108592130A5007237048 @default.
• W2108592130 hasAuthorship W2108592130A5021960841 @default.
• W2108592130 hasAuthorship W2108592130A5040015584 @default.
• W2108592130 hasAuthorship W2108592130A5063335991 @default.
• W2108592130 hasAuthorship W2108592130A5079093184 @default.
• W2108592130 hasAuthorship W2108592130A5082601500 @default.
• W2108592130 hasAuthorship W2108592130A5090670668 @default.
• W2108592130 hasAuthorship W2108592130A5090786009 @default.
• W2108592130 hasConcept C126894567 @default.
• W2108592130 hasConcept C141071460 @default.
• W2108592130 hasConcept C2776694085 @default.
• W2108592130 hasConcept C2776755627 @default.
• W2108592130 hasConcept C2778239845 @default.
• W2108592130 hasConcept C2779968505 @default.
• W2108592130 hasConcept C2781451048 @default.
• W2108592130 hasConcept C71924100 @default.
• W2108592130 hasConceptScore W2108592130C126894567 @default.
• W2108592130 hasConceptScore W2108592130C141071460 @default.
• W2108592130 hasConceptScore W2108592130C2776694085 @default.
• W2108592130 hasConceptScore W2108592130C2776755627 @default.
• W2108592130 hasConceptScore W2108592130C2778239845 @default.
• W2108592130 hasConceptScore W2108592130C2779968505 @default.
• W2108592130 hasConceptScore W2108592130C2781451048 @default.
• W2108592130 hasConceptScore W2108592130C71924100 @default.
• W2108592130 hasIssue "5" @default.
• W2108592130 hasLocation W21085921301 @default.
• W2108592130 hasLocation W21085921302 @default.
• W2108592130 hasOpenAccess W2108592130 @default.
• W2108592130 hasPrimaryLocation W21085921301 @default.
• W2108592130 hasRelatedWork W1984775533 @default.
• W2108592130 hasRelatedWork W2000611656 @default.
• W2108592130 hasRelatedWork W2046154062 @default.
• W2108592130 hasRelatedWork W2051406185 @default.
• W2108592130 hasRelatedWork W2327014840 @default.
• W2108592130 hasRelatedWork W2441108281 @default.
• W2108592130 hasRelatedWork W2595481544 @default.
• W2108592130 hasRelatedWork W3026989260 @default.
• W2108592130 hasRelatedWork W3159400989 @default.
• W2108592130 hasRelatedWork W434627019 @default.
• W2108592130 hasVolume "14" @default.
• W2108592130 isParatext "false" @default.
• W2108592130 isRetracted "false" @default.
• W2108592130 magId "2108592130" @default.
• W2108592130 workType "article" @default.