FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108596481> ?p ?o ?g. }

• W2108596481 endingPage "803" @default.
• W2108596481 startingPage "797" @default.
• W2108596481 abstract "Insulin action in skeletal muscle is enhanced by regular exercise. Whether insulin signaling in human skeletal muscle is affected by habitual exercise is not well understood. Phosphatidylinositol 3-kinase (PI3-kinase) activation is an important step in the insulin-signaling pathway and appears to regulate glucose metabolism via GLUT-4 translocation in skeletal muscle. To examine the effects of regular exercise on PI3-kinase activation, 2-h hyperinsulinemic (40 mU ⋅ m − 2 ⋅ min − 1 )-euglycemic (5.0 mM) clamps were performed on eight healthy exercise-trained [24 ± 1 yr, 71.8 ± 2.0 kg, maximal O 2 uptake (V˙o 2 max ) of 56.1 ± 2.5 ml ⋅ kg − 1 ⋅ min − 1 ] and eight healthy sedentary men and women (24 ± 1 yr, 64.7 ± 4.4 kg,V˙o 2 max of 44.4 ± 2.7 ml ⋅ kg − 1 ⋅ min − 1 ). A [6,6- 2 H]glucose tracer was used to measure hepatic glucose output. A muscle biopsy was obtained from the vastus lateralis muscle at basal and at 2 h of hyperinsulinemia to measure insulin receptor substrate-1(IRS-1)-associated PI3-kinase activation. Insulin concentrations during hyperinsulinemia were similar for both groups (293 ± 22 and 311 ± 22 pM for trained and sedentary, respectively). Insulin-mediated glucose disposal rates (GDR) were greater ( P < 0.05) in the exercise-trained compared with the sedentary control group (9.22 ± 0.95 vs. 6.36 ± 0.57 mg ⋅ kg fat-free mass − 1 ⋅ min − 1 ). Insulin-stimulated PI3-kinase activation was also greater ( P< 0.004) in the trained compared with the sedentary group (3.8 ± 0.5- vs. 1.8 ± 0.2-fold increase from basal). Endurance capacity (V˙o 2 max ) was positively correlated with PI3-kinase activation ( r = 0.53, P < 0.04). There was no correlation between PI3-kinase and muscle morphology. However, increases in GDR were positively related to PI3-kinase activation ( r = 0.60, P < 0.02). We conclude that regular exercise leads to greater insulin-stimulated IRS-1-associated PI3-kinase activation in human skeletal muscle, thus facilitating enhanced insulin-mediated glucose uptake." @default.
• W2108596481 created "2016-06-24" @default.
• W2108596481 creator A5006172063 @default.
• W2108596481 creator A5007885041 @default.
• W2108596481 creator A5015220525 @default.
• W2108596481 creator A5029909577 @default.
• W2108596481 creator A5040290418 @default.
• W2108596481 creator A5040312987 @default.
• W2108596481 creator A5078836690 @default.
• W2108596481 date "2000-02-01" @default.
• W2108596481 modified "2023-10-17" @default.
• W2108596481 title "Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle" @default.
• W2108596481 cites W1525701947 @default.
• W2108596481 cites W1651188634 @default.
• W2108596481 cites W1712871378 @default.
• W2108596481 cites W1774190872 @default.
• W2108596481 cites W1774645112 @default.
• W2108596481 cites W1837975739 @default.
• W2108596481 cites W1912682046 @default.
• W2108596481 cites W1973765080 @default.
• W2108596481 cites W1981845243 @default.
• W2108596481 cites W1984159784 @default.
• W2108596481 cites W1985601500 @default.
• W2108596481 cites W1995562367 @default.
• W2108596481 cites W1999546166 @default.
• W2108596481 cites W2010848569 @default.
• W2108596481 cites W2017709679 @default.
• W2108596481 cites W2019691564 @default.
• W2108596481 cites W2037806658 @default.
• W2108596481 cites W2090864640 @default.
• W2108596481 cites W2099004274 @default.
• W2108596481 cites W2099036955 @default.
• W2108596481 cites W2104298935 @default.
• W2108596481 cites W2109607186 @default.
• W2108596481 cites W2111923742 @default.
• W2108596481 cites W2118276311 @default.
• W2108596481 cites W2122953585 @default.
• W2108596481 cites W2144827287 @default.
• W2108596481 cites W2153074450 @default.
• W2108596481 cites W2155653958 @default.
• W2108596481 cites W2167843337 @default.
• W2108596481 cites W2168380255 @default.
• W2108596481 cites W2168588540 @default.
• W2108596481 cites W2214790450 @default.
• W2108596481 cites W2230786058 @default.
• W2108596481 cites W2279534778 @default.
• W2108596481 cites W2288774297 @default.
• W2108596481 cites W2417265484 @default.
• W2108596481 cites W2419378202 @default.
• W2108596481 cites W4251148712 @default.
• W2108596481 cites W4253396598 @default.
• W2108596481 cites W4253853026 @default.
• W2108596481 doi "https://doi.org/10.1152/jappl.2000.88.2.797" @default.
• W2108596481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10658053" @default.
• W2108596481 hasPublicationYear "2000" @default.
• W2108596481 type Work @default.
• W2108596481 sameAs 2108596481 @default.
• W2108596481 citedByCount "155" @default.
• W2108596481 countsByYear W21085964812012 @default.
• W2108596481 countsByYear W21085964812013 @default.
• W2108596481 countsByYear W21085964812014 @default.
• W2108596481 countsByYear W21085964812015 @default.
• W2108596481 countsByYear W21085964812016 @default.
• W2108596481 countsByYear W21085964812017 @default.
• W2108596481 countsByYear W21085964812018 @default.
• W2108596481 countsByYear W21085964812019 @default.
• W2108596481 countsByYear W21085964812020 @default.
• W2108596481 countsByYear W21085964812021 @default.
• W2108596481 countsByYear W21085964812022 @default.
• W2108596481 countsByYear W21085964812023 @default.
• W2108596481 crossrefType "journal-article" @default.
• W2108596481 hasAuthorship W2108596481A5006172063 @default.
• W2108596481 hasAuthorship W2108596481A5007885041 @default.
• W2108596481 hasAuthorship W2108596481A5015220525 @default.
• W2108596481 hasAuthorship W2108596481A5029909577 @default.
• W2108596481 hasAuthorship W2108596481A5040290418 @default.
• W2108596481 hasAuthorship W2108596481A5040312987 @default.
• W2108596481 hasAuthorship W2108596481A5078836690 @default.
• W2108596481 hasConcept C112446052 @default.
• W2108596481 hasConcept C126322002 @default.
• W2108596481 hasConcept C134018914 @default.
• W2108596481 hasConcept C17093226 @default.
• W2108596481 hasConcept C185592680 @default.
• W2108596481 hasConcept C2777391703 @default.
• W2108596481 hasConcept C2777866211 @default.
• W2108596481 hasConcept C2778024521 @default.
• W2108596481 hasConcept C2778808658 @default.
• W2108596481 hasConcept C2779306644 @default.
• W2108596481 hasConcept C2779959927 @default.
• W2108596481 hasConcept C2780352109 @default.
• W2108596481 hasConcept C2780988686 @default.
• W2108596481 hasConcept C71924100 @default.
• W2108596481 hasConceptScore W2108596481C112446052 @default.
• W2108596481 hasConceptScore W2108596481C126322002 @default.
• W2108596481 hasConceptScore W2108596481C134018914 @default.
• W2108596481 hasConceptScore W2108596481C17093226 @default.
• W2108596481 hasConceptScore W2108596481C185592680 @default.
• W2108596481 hasConceptScore W2108596481C2777391703 @default.

• next