FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108605191> ?p ?o ?g. }

• W2108605191 endingPage "11" @default.
• W2108605191 startingPage "1" @default.
• W2108605191 abstract "Using a duodenal perfusion technique, the biliary output of bile acids, phospholipid, and cholesterol was measured hourly during three meals and an overnight fast in seven Caucasians with radiolucent gallstones in a functioning gallbladder, and in seven health controls without gallstones, closely matched for age, sex, and weight. Before the perfusion, bile acid kinetics were defined by an isotope dilution procedure, and the biliary lipid composition of fasting gallbladder bile was determined. Total daily biliary lipid output was similar in gallstone and control subjects, and was unrelated to cholesterol saturation of fasting gallbladder bile and to bile acid pool size. There was an inverse relationship between the size and recycling frequency of the bile acid pool, so that secretion rate and hepatic return of bile acids remained constant, despite a wide range of pool sizes. The finding of a normal bile acid synthesis rate in subjects with a small pool size therefore indicated normal feedback regulation of bile acid synthesis. Hourly measurements of biliary lipid output showed a linear relationship between bile acid and cholesterol output, with a similar regression line for gallstone and control subjects, but a non-linear relationship between bile acid and phospholipid output. Consequently, samples from all subjects were consistently supersaturated with cholesterol at low bile acid outputs, especially during overnight fasting, but not at high bile acid outputs. These findings indicate that hepatic secretion of bile supersaturated with cholesterol is physiological in man at low bile acid outputs, that bile acid pool size is probably determined in part by its recycling frequency, and that cholesterol cholelithiasis in some Caucasians may be due to an underlying extrahepatic abnormality." @default.
• W2108605191 created "2016-06-24" @default.
• W2108605191 creator A5002473422 @default.
• W2108605191 creator A5090844389 @default.
• W2108605191 date "1975-01-01" @default.
• W2108605191 modified "2023-10-12" @default.
• W2108605191 title "Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects." @default.
• W2108605191 cites W148043612 @default.
• W2108605191 cites W1513741126 @default.
• W2108605191 cites W1566473841 @default.
• W2108605191 cites W1610326563 @default.
• W2108605191 cites W1614990679 @default.
• W2108605191 cites W1628383901 @default.
• W2108605191 cites W1844853079 @default.
• W2108605191 cites W185736235 @default.
• W2108605191 cites W1893563219 @default.
• W2108605191 cites W1968464339 @default.
• W2108605191 cites W2002044281 @default.
• W2108605191 cites W2006523960 @default.
• W2108605191 cites W2022822994 @default.
• W2108605191 cites W2024753390 @default.
• W2108605191 cites W2030010306 @default.
• W2108605191 cites W2041326815 @default.
• W2108605191 cites W2041515579 @default.
• W2108605191 cites W2056474881 @default.
• W2108605191 cites W2058938072 @default.
• W2108605191 cites W2064774121 @default.
• W2108605191 cites W2068466602 @default.
• W2108605191 cites W2068628030 @default.
• W2108605191 cites W2102810424 @default.
• W2108605191 cites W2103540649 @default.
• W2108605191 cites W2137698034 @default.
• W2108605191 cites W2137848503 @default.
• W2108605191 cites W2140365811 @default.
• W2108605191 cites W2146519712 @default.
• W2108605191 cites W2315045608 @default.
• W2108605191 cites W2337728933 @default.
• W2108605191 cites W2341278800 @default.
• W2108605191 cites W2344935259 @default.
• W2108605191 cites W2395020981 @default.
• W2108605191 cites W2403991107 @default.
• W2108605191 cites W2412558494 @default.
• W2108605191 cites W2413733649 @default.
• W2108605191 cites W2424995711 @default.
• W2108605191 cites W2425490811 @default.
• W2108605191 doi "https://doi.org/10.1136/gut.16.1.1" @default.
• W2108605191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1410948" @default.
• W2108605191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/806491" @default.
• W2108605191 hasPublicationYear "1975" @default.
• W2108605191 type Work @default.
• W2108605191 sameAs 2108605191 @default.
• W2108605191 citedByCount "231" @default.
• W2108605191 countsByYear W21086051912013 @default.
• W2108605191 countsByYear W21086051912015 @default.
• W2108605191 countsByYear W21086051912016 @default.
• W2108605191 countsByYear W21086051912018 @default.
• W2108605191 countsByYear W21086051912019 @default.
• W2108605191 countsByYear W21086051912020 @default.
• W2108605191 countsByYear W21086051912021 @default.
• W2108605191 crossrefType "journal-article" @default.
• W2108605191 hasAuthorship W2108605191A5002473422 @default.
• W2108605191 hasAuthorship W2108605191A5090844389 @default.
• W2108605191 hasBestOaLocation W21086051911 @default.
• W2108605191 hasConcept C126322002 @default.
• W2108605191 hasConcept C134018914 @default.
• W2108605191 hasConcept C2777148285 @default.
• W2108605191 hasConcept C2778163477 @default.
• W2108605191 hasConcept C2778918659 @default.
• W2108605191 hasConcept C2779388726 @default.
• W2108605191 hasConcept C2779399885 @default.
• W2108605191 hasConcept C2780965833 @default.
• W2108605191 hasConcept C41260117 @default.
• W2108605191 hasConcept C41625074 @default.
• W2108605191 hasConcept C55493867 @default.
• W2108605191 hasConcept C71924100 @default.
• W2108605191 hasConcept C86803240 @default.
• W2108605191 hasConcept C90924648 @default.
• W2108605191 hasConceptScore W2108605191C126322002 @default.
• W2108605191 hasConceptScore W2108605191C134018914 @default.
• W2108605191 hasConceptScore W2108605191C2777148285 @default.
• W2108605191 hasConceptScore W2108605191C2778163477 @default.
• W2108605191 hasConceptScore W2108605191C2778918659 @default.
• W2108605191 hasConceptScore W2108605191C2779388726 @default.
• W2108605191 hasConceptScore W2108605191C2779399885 @default.
• W2108605191 hasConceptScore W2108605191C2780965833 @default.
• W2108605191 hasConceptScore W2108605191C41260117 @default.
• W2108605191 hasConceptScore W2108605191C41625074 @default.
• W2108605191 hasConceptScore W2108605191C55493867 @default.
• W2108605191 hasConceptScore W2108605191C71924100 @default.
• W2108605191 hasConceptScore W2108605191C86803240 @default.
• W2108605191 hasConceptScore W2108605191C90924648 @default.
• W2108605191 hasIssue "1" @default.
• W2108605191 hasLocation W21086051911 @default.
• W2108605191 hasLocation W21086051912 @default.
• W2108605191 hasLocation W21086051913 @default.
• W2108605191 hasLocation W21086051914 @default.
• W2108605191 hasOpenAccess W2108605191 @default.
• W2108605191 hasPrimaryLocation W21086051911 @default.

• next